Abstract
The cause of a variety of chronic diseases, including arthritis, has been attributed to infection almost since the discovery of bacteria. Epidemiological, genetic, laboratory and experimental observations suggest that chronic arthritis may be a sequela of infection. With the failure to identify bacteria from within joints in rheumatoid arthritis, and with the development of techniques to detect viruses, there has been recent emphasis on seeking a virus as the cause of the characteristic persistent immune response that is seen in the synovium. It was first clearly documented1 that a virus can be associated with arthritis during an epidemic of rubella at the end of World War I. Viruses can also cause chronic inflammatory disease2,3, can evade detection and new human viruses are now often being identified4.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Geiger, J. C. (1918). Epidemic of German measles in a city adjacent to an army cantonment. J. Am. Med. Assoc., 70, 1818–1820
Norden, C. W. and Kuller, L. H. (1984). Identifying infectious etiologies of chronic disease. Rev. Infect. Dis., 6, 200–213
Haywood, A. M. (1986). Patterns of persistent viral infections. N. Engl. J. Med., 315, 939–948
Editorial (1986). An unexpected new human virus. Lancet, 2, 1430–1431
Editorial (1984). The viral aetiology of rheumatoid arthritis. Lancet, 1, 112–114
Tingle, A. J., Allen, M., Petty, R. E., Kettyls, G. D., and Chantler, J. K. (1986). Rubella associated arthritis. I. Comparative study of joint manifestations associated with natural rubella infection and RA 27/3 rubella immunisation. Ann. Rheum. Dis., 45, 110–114
White, D. G., Woolf, A. D., Mortimer, P. P., Cohen, B. J., Blake, D. R. and Bacon, P. A. (1985). Human parvovirus arthropathy. Lancet, 1, 419–421
Woolf, A. D., Campion, G. V., Chiswick, A., Wise, S., Cohen, B. J. and Dieppe, P. A. (1986). An epidemiological study of human parvovirus infection in adults. Br. J. Rheum., 25 (Suppl. 1), 2
Hurst, N. P., Martynoga, A. G., Nuki, G., Sewell, J. R., Mitchell, A. and Hughes, G. R. V. (1983). Coxsackie B infection and arthritis. Br. Med. J., 286, 605
Cohen, B. J., Buckley, M. M., Clewley, J. P., Jones, V. E., Puttick, A. H. and Jacoby R. K. (1986). Human parvovirus infection in early rheumatoid and inflammatory arthritis. Ann. Rheum. Dis., 45, 832–838
Steere, A. C., Broderick, T. F. and Malawista, S. E. (1978). Erythema chronica migrans and Lyme arthritis — Epidemiological evidence of a tick vector. Am. J. Epidemiol., 108, 312–321
Steere, A. C. and Malawista, S. E. (1985). Lyme Disease. In Kelley, W. N., Ruddy, S., Sledge, C. B. and Harris, E. D. (eds.) Textbook of Rheumatology, pp. 1557–1563. (Philadelphia: W. B. Saunders)
Engleberg, N. C. and Eisenstein, B. I. (1984). The impact of new cloning techniques on the diagnosis and treatment of infectious diseases. N. Engl. J. Med., 311, 892–901
Chantler, J. K., Ford, D. K. and Tingle, A. J. (1981). Rubella-associated arthritis: rescue of rubella virus from peripheral blood lymphocytes two years post-vaccination. Infect. Immunol., 32, 1274–1280
Peden, K., Mounts, P. and Haywood, G. S. (1982). Homology between mammalian cell DNA sequences and human herpes virus genomes detected by a hybridisation procedure with high-complexity probe. Cell, 31, 71–80
Callahan, R., Chiu, I-M., Wong, J. F. H., Pronick, S. R., Roe, B. A., Aaronson, S. A. and Schlom, J. (1985). A new class of endogenous human retroviral genomes. Science, 228, 1208–1211
Mimms, C. A., Stokes, A. and Grahame, R. (1985). Synthesis of antibodies, including antiviral antibodies, in the knee joint of patients with arthritis. Ann. Rheum. Dis., 44, 734–737
Pelton, B. K., Havey, A. R. and Denman, A. M. (1985). The rheumatoid synovial membrane participates in systemic anti-viral immune responses. Clin. Exp. Immunol., 62, 657–661
Ford, D. K., da Roa, D. M. and Schulzer, M. (1985). Lymphocytes from the site of disease but not blood lymphocytes indicate the cause of arthritis. Ann. Rheum. Dis. 44, 701–710
Ford, D. K. and da Roza, D. M. (1986). Further observations on the response of synovial lymphocytes to viral antigens in RA. J. Rheumatol., 13, 113–117
Asherson, G. I., Allwood, G. G. and Mayhew, B. (1973). Contact sensitivity in the mouse. XI. Movement of T blasts in the draining lymph nodes to sites of inflammation. Immunology, 25, 485–494
Denman, A. M. (1986). Editorial. Lymphocytes — Dolphins or enlightening rheumatological investigators? J. Rheumatol., 13, 9–12
Philips, P. E. (1986). Editorial. Lymphocyte responses to viral antigens in rheumatoid arthritis. J. Rheumatol., 13, 6–8
Mimms, C. A. and White, D. O. (1984). Interferons. In Vial Pathogenesis and Immunology pp. 167–178. (Oxford: Blackwell Scientific Publications)
Rott, R., Herzog, S., Fleischer, B., Douglas, S. D. and Pearson, C. M. (1985). Detection of serum antibodies to Borna disease virus in patients with psychiatric disorders. Science, 228, 775–756
Webb, F. W., Bluestone, R., Goldberg, L. S. et al. (1973). Experimental viral arthritis induced with herpes simplex. Arthritis Rheum., 16, 241–250
McGuire, T. C. (1984). Retro virus-induced arthritis. In Notkins, A. L. and Oldstone, M.B. A. (eds.) Concepts in Viral Pathogenesis, pp. 254–259. (New York: Springer-Verlag)
Evans, A. S. (1976). Causation and disease: the Henle-Koch postulates revisited. Yale J. Biol Med., 49, 175–195
Epstein, M. A. and Barr, Y. M. (1964). Cultivation in vitro of humanlymphoblasts from Burkitt’s malignant lymphoma. Lancet, 1, 252–253
Barre-Sinoussi, F., Cherman, J. C., Fey, F., Nugeyre, M. T., Chamaret, F., Dauguet, C., Axler-Blin, C., Vezinet-Brun, F., Rouzioux, C., Rozenbaum, W. and Montagnier, L. (1983). Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). Science, 220, 868–871
Salahuddin, S. Z., Ablashi, D. V., Markham, P. C., Josephs, S. F., Sturzenegger, S., Kaplan, M., Halligan, G., Biberfeld, P., Wong-Staal, F., Kramarsky, B. et al. (1986). Isolation of a new virus, (HBLV), in patients with lymphoproliferative disorders. Science, 234, 596–601
Wells, A., Koide, N. and Stein, H. (1983). The Epstein—Varr virus receptor is distinct from the C3 receptor. J. Gen. Virol., 64, 449–453
Laimins, L. A., Gross, P., Pozzatti, R. and Khoury, G. (1984). Characterisation of enhancer elements in the long terminal repeat of Moloney murine sarcoma virus. J. Virol., 49, 183–189
Oppenheim, J. J., Kovacs, E. J., Matsushima, K. and Durum, S. K. (1986). There is more than one interleukin-1. Immunology Today, 7, 45–56
Mimms, C. A. (1986). Interactions of viruses with the immune system. Clin. Exp. Immunol., 66, 1–16
Mimms, C. A. and White, D. O. (1984). Persistent infections. In Viral Pathogenesis and Immunology, pp. 200–253. (Oxford: Blackwell Scientific Publications)
Payne, S., Parekh, B., Montelaro, R. C. and Issel, C. J. (1984). Genomic alterations associated with persistent infections by equine infectious anaemia virus, a retrovirus. J. Gen. Virol., 65, 1395–1399
Gonezol, E., Andrews, P. W. and Plotkin, S. A. (1984). Cytomegalovirus replicates in differentiated but not in undifferentiated human embryonal carcinoma cells. Science, 224, 159–161
Narayan, O., Kennedy-Stoskepf, S., Sheffer, D., Griffin, D. E. and Clements, J. E. (1983). Activation of caprine arthritis-encephalitis virus expression during maturation of monocytes to macrophages. Infect. Immun., 41, 67–73
Oldstone, M. B. A. (1984). Viruses can alter cell function without causing cell pathology: disordered function leads to imbalance of homeostasis and disease. In Notkins, A. L. and Oldstone, M. B. A. (eds.) Concepts in Viral Pathogenesis, pp. 269–276. (New York: Springer-Verlag)
Southern, P. and Oldstone, M.A. (1986). Medical consequences of persistent viral infection. N. Engl. J. Med., 314, 359–367
von Pirquet, C. (1908). Das Verhalten der Kutanen Tuberkulin-reaktion wahrend der Masern. Dtsch. Med. Wochenschr., 34, 1297–1300
Brinton, M. A. and Nathanson, N. (1981). Genetic determinants of virus susceptibility: epidemiologic implications of murine models. Epidemiol. Rev., 3, 115–139
Marx, J. L. (1985). More about the HTLVs and how they act. Science, 229, 37–38
Chesters, P. M., Heritage, J. and McCance, D. J. (1983). Persistence DNA sequences of BK virus and JC virus in normal tissues and in diseased tissues. J.
Jalkanen, S., Steere, A. C., Fox, R. I., and Butcher, E. C. (1986). A distinct endothelial recognition system that controls lymphocyte traffic into inflamed synovium. Science, 233, 556–558
Plotz, P. H. (1983). Autoantibodies are anti-idiotype antibodies to antiviral antibodies. Lancet, 2, 824–826
Ager, E. A., Chin, T. D. Y. and Poland, J. D. (1966). Epidemic erythema infectiosum. N. Engl. J. Med., 275, 1326–1331
Woolf, A. D., Campion, G. V., Klouda, P., Chiswick, A., Cohen, B. J. and Dieppe, P. A. (1986). HLA and the clinical manifestations of human parvovirus infection. Br. J. Rheum., 25 (Suppl. 2), 35
Utsinger, P. D., Strimel, W. H., Fite, F. L. and Hicks, J. T. (1982). Viruses are a common etiology of the syndrome of fever, acute short-lived polyarthritis and rash. Arthritis Rheum., 25 (suppl.), abstract 334
Cork, L. C., Hadlow, W. J., Crawford, T. B., Gorham, J. R., and Piper, R. C. (1974). Infectious leukoencephalomyelitis of young goats. J. Infect. Dis., 129, 134–141
Crawford, T. B., Adams, D. S., Cheevers, W. P. and Cork, L. C. (1980). Chronic arthritis in goats caused by a retrovirus. Science, 207, 997–999
Haase, A. T. (1986). Pathogenesis of lentivirus infections. Nature (London), 322, 130–135
Crawford, T. B. and Adams, D. S. (1981). Caprine arthritis-encephalitis: Clinical features and the presence of antibody in selected goat populations. J. Am. Vet. Med. Assoc., 178, 713–719
Adams, D. S., Klevjer-Anderson, P., Carlson, J. L., McGuire, T. C. and Gorham, J. R. (1983). Transmission and control of caprine-arthritis encephalitis virus. Am. J. Vet. Res., 44, 1670–1675
Yaniv, A., Dahlberg, J. E., Tronick, S. R., Chiu, I-M. and Aaronsen, S. A. (1985). Molecular cloning of integrated caprine in arthritis-encephalitis virus. Virology, 145, 340–345
Crawford, T. B., Adams, D. S., Sande, R. D., Gorham, J. R. and Henson, J. B. (1980). The connective tissue component of the caprine arthritis-encephalitis syndrome. Am. J. Pathol., 100, 443–454
Adams, D. S., Crawford, T. B. and Klevjer-Andersen, P. (1980). A pathogenetic study of the early connective tissue lesions of viral caprine arthritis-encephalitis. Am. J. Pathol., 99, 257–278
Kennedy, P. G., Narayan, O., Ghotbi, Z., Hopkins, J., Geridelman, H. E., Clements, J. E. (1985). Persistent expression of la antigen and viral genome in visna-maedi virus-induced inflammatory cells. Possible role of lentivirus-induced interferon. J. Exp. Med., 162, 1970–1982
Klevjer-Anderson, P., Adams, D. S., Anderson, L. W., Banks, K. L. and McGuire, T. C. (1984). A sequential study of virus expression in retrovirus induced arthritis of goats. J. Gen. Virol., 65, 1519–1525
Klevjer-Anderson, P. and Anderson, L. W. (1982). Caprine arthritis-encephalitis virus infection of caprine monocytes. J. Gen. Virol., 58, i95–198
Bielefeldt Ohmann, H. and Babiuk, L. A. (1986). Viral infections in domestic animals as models for studies of viral immunology and pathogenesis. J. Gen. Virol., 66, 1–25
Narayan, O., Sheffer, D., Griffin, D. E., Clements, J. and Hess, J. (1984). Lack of neutralizing antibodies to caprine arthritis encephalitis lentivirus in persistently infected goats can be overcome by immunization with inactivated myobacterium tuberculosis. J. Virol., 49, 349–355
Johnson, C. G., Adams, D. S. and McGuire, T. C. (1983). Pronounced production of polyclonal IgGj in the synovial fluid of goats with caprine arthritis-encephalitis infection. Infect. Immun., 41, 805–815
Johnson, G. C., Barber, A. F., Klevjer-Anderson, P. and McGuire, T. C. (1983). Preferential immune response to virion-surface glycoproteins by caprine arthritis-encephalitis virus. Infect. Immun., 41, 657–665
Adams, D. S., Crawford, T. B., Banks, K. L., McGuire, T. C. and Perryman, L. E. (1980). Immune response of goats persistently infected with caprine arthritis-encephalitis virus. Infect. Immun., 28, 421–427
DeMartini, J. C., Banks, K. L., Greenlee, A., Adams, D. S. and McGuire, T. C. (1983). Augmented T lymphocyte responses and abnormal B lymphocyte numbers in goats chronically infected with the retrovirus causing caprine arthritis-encephalitis. Am. J. Vet. Res., 44, 2064–2069
Ray, C. G. (1983). Rubella. In Petersdorf, R. G., Adams, R. D., Braunwald, E., Isselbecher, K. J., Martin, J. B. and Wilson, J. D. (eds.) Harrison’s Principles of Internal Medicine, 10th Edn., pp. 1115–1117. (New York: McGraw-Hill)
Hope Simpson, R. E. (1940). Rubella and polyarthritis. Br. Med. J., 1, 830
Louden, I. S. L. (1953). Polyarthritis in rubella. Br. Med. J., 1, 1388
Lewis, G. W. (1953). Polyarthritis in rubella. Br. Med. J., 2, 149–150
Farquhar, J. D. and Corretjer, J. E. (1969). Clinical experience with Cendehill rubella vaccine in mature women. Am. J. Dis. Child., 118, 266–268
Spruance, S. L. and Smith, C. B. (1971). Joint complications associated with derivatives of HPV-77 rubella vaccine. Am. J. Dis. Child., 122, 105–111
Thompson, G. R., Ferreyra, A. and Brackett, R. G. (1971). Acute arthritis complicating rubella vaccination. Arthritis Rheum., 14, 19–26
Weibel, R. E., Stokes, J. Jr., Buynak, E. B. and Hilleman, M. R. (1969). Rubella vaccination in adult females. N. Engl. J. Med., 280, 682–685
Weibel, R. E., Stokes, J. Jr., Buynak, E. B. and Hilleman, M. R. (1972). Influence of age on clinical responses to HPV-77 duck rubella vaccine. J. Am. Med. Assoc. 222, 805–807
Weibel, R. E., Villarejos, V. M., Klein, E. B., Buynak, E. B., McLean, A. A. and Hilleman, M. R. (1980). Clinical and laboratory studies of live attenuated RA27/3 and HPV-77-DE rubella virus vaccines. Proc. Soc. Exp. Biol. Med., 165, 44–49
Polk, B. F., Modlin, J. F., White, J. A. and DeGirlami, P. C. (1982). A controlled comparison of joint reactions among women receiving one of two rubella vaccines. Am. J. Epidemiol., 115, 19–25
Fogel, A., Moshkowitz, A., Rannon, L. and Gerichter, Ch. B. (1971). Comparative trials of RA27/3 and Cendehill rubella vaccines in adult and adolescent females. Am. J. Epidemiol., 93, 392–398
Gerson, A. A., Frey, H. M., Borkowsky, W. and Steinberg, S. (1980). Live attenuated rubella virus vaccine: comparison of responses to HPV-77-DE5 and RA27/3 strains. Am. J. Med. Sci., 279, 95–97
Cooper, L. Z., Ziring, P. R., Weiss, H. J., Matters, B. A. and Krugman, S. (1969). Transient arthritis after rubella vaccination. Am. J. Dis. Child., 118, 218–225
Dudgeon, J. A., Marshall, W. C. and Peckham, C. S. (1969). Rubella vaccine trials in adults and children. Am. J. Dis. Child., 118, 237–242
Spruance, S. L., Metcalf, R., Smith, C. B., Griffiths, M. M. and Ward, J. R. (1977). Chronic arthropathy associated with rubella vaccination. Arthritis Rheum., 20, 741–747
Hildebrandt, H. M. and Massab, H. F. (1966). Rubella synovitis in a one-year old patient. N. Engl. J. Med., 274, 1428–1430
Ogra, P. L. and Herd, J. K. (1971). Arthritis associated with induced rubella infection. J. Immunol., 107, 810–813
Cunningham, A. L. and Fraser, J. R. E. (1985). Persistent rubella virus infection of human synovial cells cultured in vitro. J. Infect. Dis., 151, 638–645
Vergani, D., Morgan-Capner, P., Davies, E. T., Anderson, A. W., Tee, D. E. H. and Pattison, J. R. (1980). Joint symptoms, immune complexes and rubella. Lancet, 2, 321–322
Coyle, P. K., Wolinsky, J. S., Buimovici-Klein, E., Moucha, R. and Cooper, L. Z. (1982). Rubella-specific immune complexes after congenital infection and vaccination. Infect. Immun., 36, 498–503
Singh, V. K., Tingle, A. J. and Schulzer, M. (1986). Rubella-associated arthritis. II. Relationship between circulating immune complex levels and joint manifestations. Ann. Rheum. Dis., 45, 115–119
Robitaille, A., Cockburn, C., James, D. C. O. and Ansell, B. M. (1976). HLA frequencies in less common arthropathies. Ann. Rheum. Dis., 35, 271–273
Cossart, Y. E., Field, A. M., Cant, B. and Widdows, D. (1975). Parvovirus-like particles in human sera. Lancet, 1, 73
Cohen, B. J., Mortimer, P. P. and Pereira, M. S. (1983). Diagnostic assays with monoclonal antibodies for the human serum parvovirus-like virus (SPLV). J. Hyg. (London), 91, 113–131
Anderson, M. J., Davis, L. R., Hodgson, J., Jones, S. E., Murtaza, L., Pattison, J. R., Stroud, C. E., White, J. M. et al. (1982). Occurrence of infection with a parvovirus-like agent in children with sickle cell anaemia during a two-year period. J. Clin. Pathol., 35, 744–749
Young, N. and Mortimer, P. P. (1984). Viruses and bone marrow failure. Blood, 64, 729–737
Saarinen, U. M., Chorba, T. L., Tattersall, P., Young, N. S., Anderson, L. J., Palmer, E. and Coccia, P. F. (1986). Human parvovirus B19-induced epidemic acute red cell aplasia in patients with hereditary haemolytic anaemia. Blood, 67, 1411–1417
Mortimer, P. P., Humphries, R. K., Moore, J. G., Purcell, R. H. and Young, N. S. (1983). A human parvovirus-like virus inhibits haematopoetic colony formation in vitro. Nature (London), 302, 426–429
Cotmore, S. F. and Tattersall, P. (1984). Characterisation and molecular cloning of a human parvovirus genome. Science, 226, 1161–1165
Anderson, M. J., Lewis, E., Kidd, I. M., Hall, S. M. and Cohen, B. J., (1984). An outbreak of erythema infectiosum associated with human parvovirus infection. J. Hyg. (Cambridge), 93, 85–93
Reid, D. M., Reid, T. M. S., Brown, T., Rennie, J. A. N. and Eastmond, C. J. (1985). Human parvovirus-associated arthritis: a clinical and laboratory description. Lancet, 1, 422–425
Brown, T., Anand, A., Ritchie, L. D., Clewley, J. P. and Reid, T. M. S. (1984). Intrauterine parvovirus infection associated with hydrops fetalis. Lancet, 2, 1033–1034
Anderson, M. J., Higgins, P. G., Davis, L. R., Williams, J. S., Jones, S. E., Kidd, I. M., Pattison, J. R. and Tyrrell, D. A. J. (1985). Experimental parvoviral infection in humans. J. Infect. Dis., 152, 257–265
Smith, C. A., Woolf, A. D. and Lenci, M. (1987). Parvoviruses: Infections and arthropathies. Rheum. Dis. Clin. N. Am., 13, 249–264
Clewley, J. P. (1985). Detection of human parvovirus using a molecularly cloned probe. J. Med. Virol., 15, 173–181
Luzzi, G. A., Kurtz, J. B. and Chapel, H. (1985). Human parvovirus arthropathy and rheumatoid factor. Lancet, 1, 1218
Lefrere, J. J., Meyer, O., Menkes, C. J., Beaulieu, M.M. and Courouce, A-M. (1985). Human parvovirus and rheumatoid arthritis. Lancet, 1, 982
Jones, V. E., Jacoby, R. K., Puttick, A. H. and Cohen, B. J. (1986). Rheumatoid arthritis; clinical onset, seropositivity and a possible cause. Arthritis Rheum., 29, 814–815
Duffy, J., Lidsky, M. D., Sharp, J. T., Davis, J. S., Person, D. A., Holliger, F. B. and Min, K. W. (1976). Polyarthritis, polyarteritis and hepatitis B. Medicine (Baltimore), 55, 19–37
Madhavan, T. and Cox, F. (1972). Anicteric hepatitis and polyathritis. J. Am. Med. Assoc. 220, 1744–1745
Levo, Y., Gorevic, P. D., Kassab, H. J., Zucker-Franklin, D. and Franklin, E. C. (1977). Association between hepatitis B virus and essential mixed cryoglobulinaemia. N. Engl. J. Med., 296, 1501–1504
McCarty, D. J. and Ormiste, V. (1973). Arthritis and HB Ag-positive hepatitis. Arch. Intern. Med., 132, 264–268
Alpert, E., Isselbacher, K. J. and Schur, P. H. (1971) The pathogenesis of arthritis associated with viral hepatitis. N. Engl. J. Med., 285, 185–189
Koff, R. S. (1971). Immune-complex arthritis in viral hepatitis. N. Engl. J. Med., 285, 185–189
Dixon, F. J., Vasquez, J. J., Weigle, W. O. and Cochrane, C.G. (1958). Pathogenesis of serum sickness. Arch. Pathol., 65, 18
Orion, D. K., Crumpacker, C. S. and Gilliland, B. C. (1971). Arthritis of hepatitis associated with Australia antigen. Ann. Intern. Med., 765, 29–33
Wands, J. R., Mann, E., Alpert, E. and Isselbacher, K. J. (1975). The pathogenesis of arthritis associated with acute hepatitis B surface antigen-positive hepatitis. J. Clin. Invest., 55, 930–936
Rillet, M. (1850). Memoire sur une épidemie d’oreillons qui a regne a Geneve pendant les annees 1848 et 1849. Gazette Médicale de Paris, 22–25
ter Meulen, V. and Carter, M. J. (1982). Morbilliform persistent infections in animals and man. In Mahy, B. W. J., Minson, A. C. and Darby, G. K. (eds.) Viral Persistence, 33rd Symposium Soc. Gen. Microbiol. (Cambridge: Cambridge University Press)
Harvey, L. (1984). Viral aetiology of Paget’s disease of bone: a review. J. R. Soc. Med., 77, 943–948
Maisondieu, P. (1924). Etude des manifestations articularies des orieillons. Thèse pour le doctorat en médecine, Paris, Jourve No. 519
Association for the Study of Infectious Diseases (1974). A retrospective survey of the complications of mumps. J. R. Coll. Gen. Practit., 24, 552–556
Gordan, S. C. and Lauter, C. B. (1984). Mumps arthritis: a review of the literature. Rev. Infect. Dis., 6, 338–343
Gold, H.E., Boxerbaum, B. and Leslie, H.J. Jr. (1968). Mumps arthritis. Am. J. Dis. Child., 116, 547–548
Gordan, S. C. and Lanter, C. B. (1982). Mumps arthritis: Unusual presentation as adult Still’s disease. Ann. Intern. Med., 97, 45–47
Sigal, L. H., Steere, A. C. and Niederman, J. C. (1983). Symmetric polyarthritis associated with heterophile-negative infectious mononucleosis. Arthritis Rheum., 26, 553–556
Weiner, S. R. and Utsinger, P. D. (1988). Viral arthritis: a review with a description of 15 new cases. Clin. Exp. Rheumatol. (In press)
Ford, D. K., da Roza, D. M., Reid, G. D., Chantler, J. K. and Tingle, A. J. (1982). Synovial mononuclear cell responses to rubella antigen in rheumatoid arthritis and unexplained persistent knee arthritis. J. Rheumatol., 9, 420–423
Grahame, R., Armstrong; R., Simmons, N. A., Wilton, J. M. A., Dyson, M., Laurent, R., Mills, R. and Mims, C. A. (1983). Chronic arthritis associated with the presence of intrasynpvial rubella virus. Ann. Rheum. Dis., 42, 2–13
Chantler, J. K., Tingle, A. J. and Petty, R. E. (1985). Persistent rubella virus infection associated with chronic arthritis in children. N. Engl. Med. J., 18, 1117–1123
Simpson, R. W., McGinty, L., Simon, L., Smith, C. A., Godzeski, C. W. and Boyd, R. J. (1984). Association of parvoviruses with rheumatoid arthritis of humans. Science, 24, 1425–1428
Alspaugh, M. A. and Tan, E. M. (1976). Serum antibody in rheumatoid arthritis reactive with a cell-associated antigen. Arthritis Rheum., 19, 711–719
Alspaugh, M. A., Jensen, F. C., Rabin, H. and Tan, E. M. (1978). Lymphocytes transformed by the Epstein-Barr virus. Induction of nuclear antigen reactive with antibody in rheumatoid arthritis. J. Exp. Med., 147, 1018–1027
Billings, P. B., Hoch, S. O., White, P. J., Carson, D. A. and Vaughan, J. H. (1983). Antibodies to Epstein-Barr virus nuclear antigen and to rheumatoid arthritis nuclear antigen identify the same polypeptide. Proc. Natl. Acad. Sci., 80, 7104–7108
Venables, P. J. W., Roffe, L. M., Erhardt, C. C. et al. (1981). Titres of antibodies of RANA in rheumatoid arthritis and normal sera. Arthritis Rheum., 24, 1459
Luka, J., Kreofsky, T., Pearson, G. R., Hennessy, K. and Keiff, E. (1984). Identification and characterisation of a cellular protein that cross-reacts with the Epstein-Barr virus nuclear antigen. J. Virol., 52, 833–838
Fox, R. I., Lotz, M., Rhodes, G. and Vaughan, J. H. (1985). Epstein-Barr virus in rheumatoid arthritis. Clin. Rheum. Dis., 11, 665–688
Depper, J. M., Bluestein, H. G. and Zvaigler, N. J. (1981). Impaired regulation of Epstein-Barr virus-induced lymphocyte proliferation in rheumatoid arthritis is due to a T cell defect. J. Immunol., 127, 1899–1902
Tosato, G., Steinberg, A. D. and Blaese, R. M. (1981). Defective EBV-specific suppressor T-cell function in rheumatoid arthritis. N. Engl. J. Med., 305, 1238–1243
Tosato, G., Steinberg, A. D., Yarchoan, R., Heilman, C. A., Pike, S. E., De Seau, V. and Blaese, R. M. (1984). Abnormally elevated frequency of Epstein-Barr virus-infected B cells in the blood of patients with rheumatoid arthritis. J. Clin. Invest., 73, 1789–1795
Stastny, P. (1978). Association of the B-cell alloantigen DRW4 with rheumatoid arthritis. N. Engl. J. Med., 298, 869–871
Panayi, G. S., Wooley, P. and Batchelor, J. R. (1978). Genetic basis of rheumatoid disease: HLA antigens, disease manifestations and toxic reactions to drugs. Br. Med. J., 2, 1326–1328
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Kluwer Academic Publishers
About this chapter
Cite this chapter
Woolf, A.D. (1989). Viral Infections and Chronic Arthritis. In: Calabro, J.J., Dick, W.C. (eds) Infections and Arthritis. New Clinical Applications Rheumatology , vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0845-1_3
Download citation
DOI: https://doi.org/10.1007/978-94-009-0845-1_3
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-6867-3
Online ISBN: 978-94-009-0845-1
eBook Packages: Springer Book Archive