Abstract
This paper describes how a fluid mechanism provides a new method for the separation of drops and particles from the type of dilute suspension common in biochemical processes.
Lateral migration is a low Reynolds number fluid phenomenon observed in laminar duct flow. The mechanism causes the dispersed phase of drops or particles to migrate across flow streamlines to a characteristic equilibrium position. This paper considers only the behaviour of single particles. The equilibrium streamline is dependent on the settling velocity of the dispersed phase, the bulk velocity and the ratio of particle diameter to channel height. Preliminary results, using a scaled-up channel, are presented.
The technique is particularly attractive for the continuous separation of dilute suspensions of droplets and particles ≥50 μm with very low settling terminal velocities and which may be shear sensitive. This type of separation is not effectively fulfilled by continuous centrifuges. The proposed system is both easily and cheaply constructed and since it has no moving mechanical parts is ideally suited to operation behind containment or in aseptic conditions as required by the biotechnology industry.
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© 1990 United Kingdom Atomic Energy Authority
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Purdom, G.J., Lambe, C.A. (1990). Lateral Migration: A laminar fluid flow mechanism suited to Biotechnology separations. In: Pyle, D.L. (eds) Separations for Biotechnology 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0783-6_10
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DOI: https://doi.org/10.1007/978-94-009-0783-6_10
Publisher Name: Springer, Dordrecht
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