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Growth Patterns and Skeletal Maturation During Sex Steroid Suppression and Reactivation in Central Precocious Puberty

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GnRH Analogues in Cancer and Human Reproduction

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Abstract

Children with centrally-mediated precocious puberty (CPP) undergo a sequence of hypothalamic-pituitary-gonadal activation which appears to be normal except for the age of its occurrence. Premature exposure to gonadal steroids in children with precocity is associated with an acceleration of linear growth identical to the adolescent growth spurt save for the age of its occurrence. Skeletal maturation is even more markedly advanced by this early exposure to gonadal steroids in these patients, often leading to early epiphyseal fusion and compromised adult stature [1–3]

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Authors and Affiliations

  1. The Reproductive Endocrine Unit, Vincent Research Laboratories, Boston, MA, 02114, USA

    Paul A. Boepple, M. Joan Mansfield, John D. Crawford, Kathleen Link & Robert M. Blizzard

Authors
  1. Paul A. Boepple
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  2. M. Joan Mansfield
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  3. John D. Crawford
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  4. John F. Crigler Jr.
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  5. Robert M. Blizzard
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  6. William F. Crowley Jr.
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Editor information

Editors and Affiliations

  1. Syntex Research, Institute of Biological Science, Palo Alto, CA, 94304, USA

    B. H. Vickery

  2. Institute of Endocrinology, Sheba Medical Center and Bar Ilan University, Remat Gan, 52621, Israel

    B. Lunenfeld

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© 1990 Kluwer Academic Publishers

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Boepple, P.A. et al. (1990). Growth Patterns and Skeletal Maturation During Sex Steroid Suppression and Reactivation in Central Precocious Puberty. In: Vickery, B.H., Lunenfeld, B. (eds) GnRH Analogues in Cancer and Human Reproduction. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0725-6_7

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  • DOI: https://doi.org/10.1007/978-94-009-0725-6_7

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6811-6

  • Online ISBN: 978-94-009-0725-6

  • eBook Packages: Springer Book Archive

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