Abstract
Since 1960 we have treated in our Institute 209 children with central (true) precocious puberty (CPP). Out of these only 2 male patients had CNS tumors (optic nerve glioma and glioblastoma), in the others the process was idiopathic. Depending upon the time period, the drugs used varied (Table 1). The results obtained
with medroxyprogesterone acetate (Depo-Provera, Upjohn) were not satisfactory [1]. The first drug which seemed to have long-term effects in suppressing the precocious gonadotropin secretion, slowing the rate of skeletal maturation and thus prolonging the period of growth, was cyproterone acetate (Androcur, Schering) [2]. However, with increasing experience it was observed that on prolonged administration, “escape phenomena” occurred and that an improved final height was often not achieved. In 1980, trying in children with hypogonadotropic hypogonadism the long-term stimulatory activity of a superactive GnRH analog ([D-Trp6] LHRH) we observed that the stimulatory phase was followed by a blocking effect [3], therefore, immediately tried to find out whether this property of paradoxical refractoriness of the gonadotropic cells induced by long-term use of a GnRH agonist could be exploited in the treatment of precocious puberty.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Laron, Z and Rumney, G (1965). Treatment of precocious sexual development by medroxy-progesterone acetate. Acta Endocrinol (Copenh), Suppl 100, 27, Abstract
Kauli, R, Pertzelan, A, Prager-Lewin, R, Grunebaum, M and Laron, Z (1976). Cyproterone acetate in treatment of precocious puberty. Arch Dis Child, 51, 202
Laron, Z, Dickerman, Z, Ben-Zeev, Z, Prager-Lewin, R, Comaru-Schally, AM and Schally, AV (1981). Long term effect of [D-Trp6]LHRH on testicular size and LH, FSH and testosterone levels in hypothalamic hypogonadotrophic males. Fertil Steril, 35, 328
Laron, Z, Kauli, R, Ben-Zeev, Z, Comaru-Schally, SM and Schally, AV (1981). D-TRP6 analogue of LH-RH in combination with cyproterone acetate to treat precocious puberty. Lancet, 11, 955
Kauli, R, Pertzelan, A, Ben Zeev, Z, Prager-Lewin, R, Kaufman, H, Comaru-Schally, AM, Schally, AV and Laron, Z (1984). Treatment of precocious puberty with LH-RH analogue in combination with cyproterone acetate — further experience. Clin. Endocrinol, 20, 377
Zilka, E and Laron, Z (1969). The normal testicular volume in Israeli children and adolescents. Harefuah, 77, 511
Greulich, WW and Pyle, SI (1959). “Radiographic Atlas of Skeletal Development of Hand and Wrist”. 2nd Edition (Stanford: Stanford University Press)
Galatzer, A, Beit-Halachmi, N, Kauli, R and Laron, Z (1984). Intellectual function of girls with precocious puberty. Pediatrics, 74. 246
Kauli, R, Keret, R and Laron, Z (1986). Growth hormone is normal in girls with precocious puberty during suppressive therapy with LH-RH analogue (D-TRP-6-LH-RH). Pediat Res, 20, 1198
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Kluwer Academic Publishers
About this chapter
Cite this chapter
Kauli, R., Schally, A.V., Laron, Z. (1990). Long Term Experience with a Superactive GnRH Analog in the Treatment of Precocious Puberty. In: Vickery, B.H., Lunenfeld, B. (eds) GnRH Analogues in Cancer and Human Reproduction. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0725-6_5
Download citation
DOI: https://doi.org/10.1007/978-94-009-0725-6_5
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-6811-6
Online ISBN: 978-94-009-0725-6
eBook Packages: Springer Book Archive