Abstract
Because of the existence of anaphylactoid side effects following the subcutaneous (sc) injection of first generation antagonists of the [D-Arg6] class, there have been few clinical trials using GnRH antagonists in humans. These agents cause mast cell degranulation and histamine release [1, 2]. Recently, new classes of compounds have been designed and are available for phase 1 clinical trials.
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References
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© 1990 Kluwer Academic Publishers
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Bouchard, P. et al. (1990). Clinical Studies with the Nal-Glu GnRH Antagonist. In: Vickery, B.H., Lunenfeld, B. (eds) GnRH Analogues in Cancer and Human Reproduction. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0725-6_14
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DOI: https://doi.org/10.1007/978-94-009-0725-6_14
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-6811-6
Online ISBN: 978-94-009-0725-6
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