Abstract
Previously, analysis of epitopes on proteins has been beyond the capacity of classical immunochemistry. Instead, ingenious ways have been developed to couple a vast number of low molecular weight chemicals to protein carriers and to assess the antibody response against the artificial structures thus created. The covalent attachment of the haptenic compounds mainly involved azo linkages, but other possibilities such as carboxamide bonds have also been used1,2. The studies gained importance when it was realized that immediate-type allergies against low molecular weight drugs and chemicals involved covalent attachment of these entities to proteinaceous carrier structures as an obligatory step. Only above a certain molecular size, around 500 Daltons, is the requirement for covalent attachment not so strict. With peptides, for instance, a number of uncoupled peptides of about 1000 Daltons have been described in the sixties as immunogens or allergens capable of evoking antibody responses3.
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Schneider, CH, Rolli, H and Kasper, MF (1990). Note on the immunochemical specificity of pyrazolinone and pyrazolidinedione reactions. Submitted for publication
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© 1989 Kluwer Academic Publishers
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Schneider, C.H. (1989). Immunochemical studies on azapropazone. In: Rainsford, K.D. (eds) Azapropazone. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0713-3_11
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DOI: https://doi.org/10.1007/978-94-009-0713-3_11
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