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Pretransplant Immunological Considerations

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The Transplantation and Replacement of Thoracic Organs

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Abstract

Since numerous detailed accounts of transplantation immunology appear elsewhere in the literature1–3 and the mechanism of allograft destruction is outlined in Chapter 14, this chapter will concentrate only on those pretransplant immunological aspects that are of practical clinical importance before a cardiac transplant is performed. Four topics will be discussed: (1) the necessity for donor-recipient ABO blood group compatibility, (2) the role of human leukocyte antigen (HLA) matching, (3) the lymphocytotoxic crossmatch test and the problem of preformed antibodies, and (4) the effect of pretransplant blood transfusions in recipients of cardiac allografts.

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Authors
  1. E. D. Du Toit
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  2. M. Oudshoorn
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  3. D. K. C. Cooper
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Editors and Affiliations

  1. Baptist Medical Center, Oklahoma Transplantation Institute, Oklahoma City, Oklahoma, USA

    David K. C. Cooper MA, MD, PhD, FRCS (Cardiothoracic Surgeon and Director of Research and Education, Formerly, Associate Professor of Cardiothoracic Surgery) & Dimitri Novitzky MD, FCS (SA) (Cardiothoracic Surgeon, Formerly, Specialist in Cardiothoracic Surgery) (Cardiothoracic Surgeon and Director of Research and Education, Formerly, Associate Professor of Cardiothoracic Surgery) &  (Cardiothoracic Surgeon, Formerly, Specialist in Cardiothoracic Surgery)

  2. University of Cape Town Medical School and Groote Schuur Hospital, Cape Town, South Africa

    David K. C. Cooper MA, MD, PhD, FRCS (Cardiothoracic Surgeon and Director of Research and Education, Formerly, Associate Professor of Cardiothoracic Surgery) (Cardiothoracic Surgeon and Director of Research and Education, Formerly, Associate Professor of Cardiothoracic Surgery)

  3. Groote Schuur Hospital, Cape Town, South Africa

    Dimitri Novitzky MD, FCS (SA) (Cardiothoracic Surgeon, Formerly, Specialist in Cardiothoracic Surgery) (Cardiothoracic Surgeon, Formerly, Specialist in Cardiothoracic Surgery)

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Toit, E.D.D., Oudshoorn, M., Cooper, D.K.C. (1990). Pretransplant Immunological Considerations. In: Cooper, D.K.C., Novitzky, D. (eds) The Transplantation and Replacement of Thoracic Organs. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0711-9_8

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  • DOI: https://doi.org/10.1007/978-94-009-0711-9_8

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