Abstract
The development of successful methods of myocardial protection during open heart operations has been one of the major advances in cardiac surgery. At present, cardioplegic arrest followed by simple storage in ice-cold saline provides good protection of the myocardium against ischemic damage for up to 4 hours, possibly a little longer. This allows for transport of a donor heart from one hospital to another over distances of up to approximately 2000 km (1250 miles), but necessitates highly organized and expensive forms of communication and transportation between these centers.
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References
Cooper, D.K.C. (1976). The donor heart; the present position with regard to resuscitation, storage and assessment of viability. J. Surg. Res., 21, 363
Lehninger, A.L. (1975). Catabolism and generation of the phosphate bond energy. In Biochemistry: The Molecular Basis of Cell Structure and Function, 2nd ed., p. 361. (New York: Worth)
Pegg, D.E. (1981). The biology of cell survival in vitro. In Karow, A.M. and Pegg, D.E.(eds.)Organ Preservation for Transplantation, 2nd ed., p. 31. (New York and Basel: Dekker)
Leading article (1973). Reporting the proceedings of the first international symposium on organ preservation. Cambridge. Lancet, 2, 715
Kirsh, M.M., Behrendt, D.M. and Jockim, K.E. (1979). Effects of methylprednisolone in cardioplegie solution during coronary bypass grafting. J. Thorac. Cardiovasc. Surg., 77, 896
Fox, A.C., Hoffstein, S. and Weissmann, G. (1976). Lysosomal mechanisms in production of tissue damage during myocardial ischemia and the effects of treatment with steroids. Am. Heart J., 91, 394
Novitzky, D., Cooper, D.K.C., Wicomb, W.N. and Reichart, B. (1986). Improved function of stored hearts following hormonal therapy after brain death in pigs. Transplant Proc., 18, 1419
Wicomb, W.N, Cooper, D.K.C, and Novitzky, D. (1986). Impairment of renal slice function following brain death, with reversibility of injury by hormonal therapy. Transplantation, 41, 29
Cooper, D.K.C. (1976). Resuscitation of the cadaver donor heart in the dog. III. The influence of the agonal period on the success of resuscitation. Guy’s Hosp. Rep., 123, 363
Wicomb, W.N, Cooper, D.K.C, Novitzky, D. and Barnard, C.N. (1984). Cardiac transplantation following storage of the donor heart by a portable hypothermic perfusion system. Ann. Thorac. Surg., 37, 243
Bogardus, G.M. and Schlosser, R.J. (1956). The influence of temperature upon ischemic renal damage. Surgery, 39, 970
Gott, V.L, Bartlett, M, Johnson, J.A, Long, D.M. and Lillehei, C.W. (1960). High energy phosphate levels in the human heart during potassium citrate arrest and selective hypothermic arrest. Surg. Forum, 10, 544
Greenberg, J.J, Edmunds, L.H. and Brown, R.B. (1960). Myocardial metabolism and post-arrest function in the cold and chemically arrested heart. Surgery, 48, 31
Webb, W.R. and Howard, H.S. (1957). Cardiopulmonary transplantation. Surg. Forum, 8, 313
Lower, R.R, Stofer, R.C, Hurley, E.J, Dong, E.Jr, Cohn, R.B. and Shumway, N.E. (1962). Successful homotransplantation of the canine heart after anoxic preservation for seven hours. Am. J. Surg., 104, 302
Bigelow, W.G, Mustard, W.T. and Evans, J.G. (1954). Some physiological concepts of hypothermia and their application to cardiac surgery. J. Thorac. Surg., 28, 480
Gevers, W. (1977). Generation of protons by metabolic processes in heart cells. J. Mol. Cell Cardiol., 9, 867
Hand, S.C. and Somero, G.N. (1982). Urea and methylamine effects on rabbit muscle phosphofructokinase. J. Biol. Chem., 257, 734
Parr, D.R, Wimshurst, J.M. and Harris, E.J. (1975). Calcium-induced damage of rat heart mitochondria. Cardiovasc. Res., 9, 366
Ganote, C.E, Worstell, J. and Kaltenbach, J.P. (1976). Oxygen-induced enzyme release irreversible myocardial injury; effects of cyanide in perfused rat hearts. Am. J. Pathol., 84, 327
Jennings, R.B. and Ganote, C.E. (1976). Mitochondrial structure and function in acute myocardial ischemic injury. Circ. Res., 38, (Suppl. 1), 80
Melrose, R.G, Dreyer, B, Bentall, H.H. and Baker, J.B.E. (1955). Elective cardiac arrest. Lancet, 2, 21
Hearse, D.J, Stewart, D.A. and Chain, E.B. (1974). Recovery from cardiac bypass and elective cardiac arrest. The metabolic consequences of various cardioplegie procedures in the isolated rat heart. Circ. Res., 35, 448
Nakae, S, Webb, W.R, Salyer, K.E, Unal, M.O, Cook, W.A, Dodds, R.P. and Williams, C.T. (1957). Extended survival of the normothermic anoxic heart with metabolic inhibitors. Ann. Thorac. Surg., 3, 37
Hearse, D.J, Stewart, D.A. and Braimbridge, M.V. (1976). Cellular protection during myocardial ischemia. Circulation, 54, 193
Kamiyama, T.M, Webb, W.R. and Baker, R.R. (1970). Preservation of the anoxic heart with a metabolic inhibitor and hypothermia. Arch. Surg., 100, 596
Reitz, B.A, Brody, W.R, Hickey, P.R. and Michaelis, L.L. (1974). Protection of the heart for 24 hours with intracellular (high K +) solution and hypothermia. Surg. Forum, 25, 149
Wicomb, W.N. and Cooper, D.K.C. (1984). Donor heart storage. In Cooper, D.K.C. and Lanza, R.P. (eds.) Heart Transplantation, p. 51, (Lancaster: MTP Press)
Barnard, M.S., Van Heerden, J, Hope, A, O’Donovan, T.G. and Barnard, C.N. (1969). Total body perfusion for cardiac transplantation. S. Afr. Med. J., 43, 64
Demikhov, V.P. (1962). Experimental Transplantation of Vital Organs. Authorized translantion from the Russian by Haigh, B. (New York: Consultants Bureau)
Robicsek, F, Stam, R.E, Rees, T.T, Taylor, F.H. and Sanger, P.W. (1959). Transplantation of the heart. 2. Haemodynamic observations of the isolated heart. Heineman Laboratories Collected Works on Cardiopulmonary Disease, 1–2, 96
Yamada, T, Bosher, L.R.Jr. and Richardson, G.M. (1965). Observations on the autoperfusing heart—lung preparation. Trans. Am. Soc. Artif. Intern. Organs, 11, 192
Robicsek, F, Lesage, A, Sanger, P.W, Daugherty, H.K, Moore, M. and Bagby, E. (1968). The maintenance of function of the donor heart in the extracorporeal stage and during transplantation. Ann. Thorac. Surg., 6, 331
Cooper, D.K.C. (1975). Hemodynamic studies during short-term preservation of the autoperfusing heart—lung preparation. Cardiovasc. Res., 9, 753
Dupree, E.L., Mills, M, Clark, R. and Sell, K.W. (1969). Xenogeneic storage of primate hearts. Transplant. Proc., 1, 840
Solis, E, Tyce, G.M, Bianco, R, Mahoney, J. and Kaye, M.P. (1986). High energy phosphates and catecholamine stores after prolonged ex vivo heart preservation. J. Heart Transplant., 5, 444
Proctor, E. and Parker, R. (1968). Preservation of isolated heart for 72 hours. Br. Med. J., 4, 296
Copeland, J.G, Jones, M, Spragg, R. and Stinson, E.B. (1973). In vitro preservation of canine heart for 24 to 48 hours followed by successful orthotopic transplantation. Ann. Surg., 178, 687
Kioka, Y, Tago, M, Bands, K, Seno, S, Shinozaki, Y, Murakami, T, Nawa, S, Senoo, Y. and Teramoto, S. (1986). Twenty-four hours isolated heart preservation by perfusion method with oxygenated solution containing perfluorochemicals and albumin. J. Heart Transplant., 5, 437
Cooper, D.K.C, Wicomb, W.N. and Barnard, C.N. (1983). Storage of the donor heart by a portable hypothermic perfusion system: experimental development and clinical experience. J. Heart Transplant., 2, 104
Cooper, D.K.C, Wicomb, W.N, Rose, A.G. and Barnard, C.N. (1983). Orthotopic allotransplantation and autotransplantation of the baboon heart following twenty-four hours storage by a portable hypothermic perfusion system. Cryobiology, 20, 385
Wicomb, W.N, Novitzky, D, Cooper, D.K.C. and Rose, A.G, (1986). Forty-eight hours hypothermic perfusion storage of pig and baboon hearts. J. Surg. Res., 40, 276
Wicomb, W.N, Rose, A.G, Cooper, D.K.C. and Novitzky, D. (1986). Hemodynamic and myocardial histological and ultrastructural studies in baboons three to twenty-seven months following autotransplantation of hearts stored by hypothermic perfusion for 24 or 48 hours. J. Heart Transplant., 5, 122
Wicomb, W.N, Cooper, D.K.C, Lanza, R.P, Novitzky, D. and Isaacs, S. (1986). The effects of brain death and 24 hours storage by hypothermic perfusion on donor heart function in the pig. J. Thorac. Cardiovasc. Surg., 91, 896
Martin, C.D., Scott, D.F., Downes, G. and Belzer, F.O. (1972). Primary cause of unsuccessful liver and heart preservation; cold sensitivity of the ATPase system. Ann. Surg., 175, 111
Lyons, J.M. and Raison, J.K. (1970). A temperature-induced transition in mitochondrial oxidation; contrasts between cold- and warmblooded animals. Comp. Biochem. Physiol., 37, 405
Kemp, A., Groot, G.S.P. and Reemtsma, H.J. (1969). Oxidative phosphorylation as a function of temperature. Biochem. Biophys. Acta, 180, 28
Zimmerman, A.N.E., Daems, W., Huismann, W.C., Snijder, J., Wisse, E. and Durrer, D. (1967). Morphological changes of heart muscle caused by successive perfusing with Ca+ +-free and Ca+ +-containing solutions (Calcium paradox). Cardiovasc. Res., 1, 201
Alto, L.E. and Dhalla, N.S. (1981). Role of changes in microsomal calcium uptake on the effects of reperfusion of Ca+ +-deprived rat hearts. Circ. Res., 48, 17
Katz, A.M. and Tada, M. (1972). The ’stone heart’; a challenge to the biochemist. Am. J. Cardiol., 29, 578
Wicomb, W.N. and Collins, G.M. (1989). Twenty-four hour rabbit heart storage with UW solution: effects of low flow perfusion, colloid, and shelf storage. Transplantation, 48, 6
Toledo-Pereyra, L.H. (1987). Definition of reperfusion injury in transplantation. Transplantation, 43, 931
Naylor, W.G., Poole-Wilson, P.A. and William, A. (1979). Hypoxia and calcium. J. Mol. Cell Cardiol., 11, 683
Jennings, R.B. and Ganote, C.E. (1976). Mitochondrial structure and function in acute myocardial ischemic injury. Circ. Res., 38, (Suppl. I), 80
Opie, J.C., Taylor, G., Ashmore, P.G. and Kalousek, D. (1981). “Stone heart” in the neonate. J. Thorac. Cardiovasc. Surg., 81, 459
McCord, J.M. (1985). Oxygen derived free radicals in post-ischemic tissue injury. N. Engl. J. Med., 312, 159
Ytrehus, K., Myklebust, R. and Mjos, O.D. (1986). Influence of oxygen radicals generated by xanthine oxidase in the isolated perfused rat heart. Cardiovasc. Surg., 20, 597
Hess, M.L., Warner, M.R., Roblins, A.D., Crute, S. and Greenfield, L.J. (1981). Characterization of the excitation-contraction coupling system of the hypothermic myocardium following ischemia and reperfusion. Cardiovasc. Res., 15, 380
Jennings, R.B., Ganote, C.E. and Reimer, K.A. (1975). Ischemic tissue injury. Am. J. Pathol., 81, 197
Trump, B.F. and Berezesky, I.K. (1983). The role of Ca+ + deregulation in cell injury and cell death. Surv. Synth. Path. Res., 2, 165
Naylor, W.G. (1983). Calcium and cell death. Eur. Heart. J., 4, (Suppl.), 33
Shen, A.C. and Jennings, R.B. (1972). Myocardial calcium and magnesium in acute ischemic injury. Am. J. Pathol., 67, 417
Beatrice, M.C., Stiers, D.L. and Pfeiffer, D.R. (1984). The role of glutathione in the retention of Ca++ by liver mitochondria. J. Biol. Chem., 259, 1279
Rodemann, H.P., Waxman, L. and Goldberg, A.L. (1982). The stimulation of protein degradation in muscle by Ca+ is mediated by PGE2 and does not require the calcium activated protease. J. Biol. Chem., 257, 8716
Etlinder, J.D., Kameyama, T., Toner, K., Van der Westhuyzen, D. and Matsumoto, K. (1980). In Pette, D. (ed.) Plasticity of Muscle., p. 541. (New York: Walter de Gruyter)
Goldberg, A.L. and St. John, A.C. (1974). Intracellular protein degradation in mammalian and bacterial cells. Ann. Rev. Biochem., 45, 747
Lee, S. L. and Dhalla, N.S. (1976). Subcellular calcium transport in failing hearts due to calcium deficiency and overload. Am. J. Physiol., 231, 1159
Moorhouse, P.C., Grootveld, M., Halliwell, B., Quinlan, J.E. and Gutteridge, J.M.C. (1987). Allopurinol and oxypurinol are hydroxyl radical scavengers. FEBS. Lett., 213, 23
Bergsland, J., Lobalsamo, L., Lajos, P., Feldman, M.J. and Mookerjee, B. (1987). Allopurinol in prevention of perfusion injury of hypoxically stored rat hearts. J. Heart Transplant., 6, 137
Myers, C.L., Weiss, SJ., Kirsch, M.M., Shephard, B.M. and Shlafer, M. (1986). Effects of supplementing hypothermic crystalloid cardioplegic solution with catalase superoxide dismutase, allopurinol, or deferoxamine on functional recovery of globally ischemic and reperfused isolated hearts. J. Thorac. Cardiovasc. Surg., 91, 281
Christoffersen, G.R.J, and Skibsted, L.H. (1975). Calcium ion activity in physiological salt solutions: influences of anions substituted for chloride. Comp. Biochem. Physiol., 52A, 317
Kopf, G.S., Chaudry, I., Condos, S. and Baue, A.E. (1987). Reperfusion with ATP-MgCl2 following prolonged ischemia improves myocardial performance. J. Surg. Res., 43, 114
Kajiyama, K., Pauly, D.F., Hughes, H., Yoon, S.B., Entman, M.L. and McMillan-Wood, J.B. (1987). Protection by verapamil of mitochondrial glutathione equilibrium and phospholipid changes during reperfusion of ischemic canine myocardium. Circ. Res., 61, 301
Chien, K.R., Abrams, J., Pfau, R.G. and Farber, J.L. (1977). Prevention by chlorpromazine of ischemic liver cell death. Am. J. Pathol., 88, 539
Pryor, W.A. (1976). The role of free radical reactions in biological systems. In Pryor, W.A. (ed.) Free Radicals in Biology, p. 1. (New York: Academic Press)
Fridovich, I. (1978). The biology of oxygen radicals. Science, 201, 875
Fridovich, I. (1970). Quantitative aspects of the production of superoxide anion radical by milk xanthine oxidase. J. Biol. Chem., 245, 4053
Fee, J.A. and Valentine, J.S. (1977). Chemical and physical properties of superoxide. In Michelson, A.M., McCord, J.M. and Fridovich, I. (eds.) Superoxide and Superoxide Dismutase. p. 19. (New York: Academic Press)
Nilsson, R., Pick, F.M. and Bray, R.C. (1969). EPR studies on reduction of oxygen to superoxide by some biochemical systems. Biochem. Biophys. Acta, 192, 145
Estabrook, R.A. and Werringloer, J. (1977). Cytochrome P450: its role in oxygen activation for drug metabolism. In Gould, R.F. (ed.) Drug Metabolism Concepts, p.l. (Washington, DC: American Chemical Society)
Masters, C. and Holmes, R. (1977). Peroxisomes: new aspects of cell physiology and biochemistry. Physiol. Rev., 57, 816
Samuelson, B. (1983). Leukotrines: mediators of immediate hypersensitivity reactions and inflammation. Science, 220, 568
Klebanoff, S.J. (1980). Oxygen metabolism and the toxic properties of phagocytes. Ann. Intern. Med., 93, 480
Mead, J.F. (1976). Free radical mechanisms of lipid damage and consequences of cellular membranes. In Pryor, W.A. (ed.) Free Radicals in Biology. Vol. I, p. 51. (New York: Academic Press)
Maridonneau, I., Braquet, P. and Garay, R.P. (1983). Na+ and K + transport damage induced by oxygen free radicals in human red cell membranes. J. Biol. Chem., 258, 3107
Moody, C.S. and Hasson, H.M. (1982). Mutagenicity of oxygen free radicals. Proc. Natl. Acad. Sci. USA, 79, 2855
Fligiel, S.E.G., Lee, E.C. and McCoy, J.P. (1984). Protein degradation following treatment with hydrogen peroxide. Am. J. Pathol., 115, 418
Perez, H.D., Wedsler, B.B. and Goldstein, I.M. (1980). Generation of a chemotactic lipid from arachidonic acid by exposure to a superoxide generating system. Inflammation, 4, 313
Oguma, F., Imai, S. and Eguchi, S. (1986). Role played by oxygen in myocardial protection with crystalloid cardioplegic solution. Ann. Thor. Surg., 42, 172
Coetzee, A., Kotze, J., Law, J. and Lochner, A. (1986). Effect of oxygenated crystalloid cardioplegia on the functional and metabolic recovery of the isolated perfused rat heart. J. Thorac. Cardiovasc. Surg., 91, 259
Rousou, J.A, Engelman, R.M, Anisimowicz, L, Lemeshow, S, Dobbo, W.A, Breyer, R.H. and Das, D.K. (1986). Metabolic enhancement of myocardial preservation during cardioplegic arrest. J. Thorac. Cardiovasc. Surg., 91, 270
Otani, H, Engelman, R.M., Rousou, J.A., Breyer, R.H., Lemeshow, S. and Das, D.K. (1986). Cardiac performance during reperfusion improved by pretreatment with oxygen free radical scavengers. J. Thorac. Cardiovasc. Surg., 91, 290.
Prodjian, A.K, Levitsky, S, Krukenkamp, I, Silverman, N.A. and Feinberg, H. (1987). Developmental changes in reperfusion injury. J. Thorac. Cardiovasc. Surg., 93, 428
Mak, I.T., Misra, H.P. and Weglicki, W.B. (1983). Temporal relationship of free radical-induced lipid peroxidation and loss of latent enzyme activity in highly enriched hepatic lysosomes. J. Biol. Chem., 258, 13733
Kramer, J.H, Mak, I.T. and Weglicki, W. B. (1984). Differential sensitivity of canine cardiac sarcolemmal and microsomal enzymes to inhibition by free radical-induced lipid peroxidation. Circ. Res., 55, 120
Lucy, J.A. (1972). Functional and structural aspects of biological membranes: a suggested structural role of vit. E in the control for membrane permeability and stability. Ann. NY Acad. Sci., 203, 4
Packer, J.E, Slater, T.F. and Willson, R.L. (1979). Direct observation of a free radical interaction between vit. E and vit. C. Nature (London), 278, 737
Frank, L. and Massaro, D. (1980). Oxygen toxicity. Am. J. Med., 69, 117
Halliwell, B. (1982). Superoxide and superoxide-dependent formation of hydroxyl radicals are important in oxygen toxicity. Trends. Biochem. Sci., Aug, 271
Laurence, R.A. and Burk, R.F. (1978). Species tissue and subcellular distribution of non-selenium dependent glutathione peroxidase activity. J. Nutr., 108, 211
Al-Timini, D.J. and Dormandy, T.L. (1977). The inhibition of lipid autoxidation by human ceruloplasmin. Biochem. J., 168, 283
Miller, J.S. and Cornwell, D.G. (1978). The role of cryoprotective agents as hydroxyl radical scavengers. Cryobiology, 15, 585
Collins, G.M., Wicomb, W.N. and Halasz, N.A. (1984). Beneficial effect of low concentrations of cryoprotective agents on short-term rabbit kidney perfusion. Cryobiology, 21, 246
Menasche, P, Grousset, C, Gauduel, Y. and Piwnica, A. (1986). A comparative study of free radical scavengers in cardioplegic solutions. J. Thorac. Cardiovasc. Surg., 92, 264
McCord, J. and Fridovich, I. (1980). Superoxide dismutase: threat and defense. Acta Physiol. Scand. (Suppl.), 492, 9
Belzer, F.O. and Southard, J. (1988). Principles of solid-organ preservation by cold storage. Transplantation, 45, 673
Houpert, Y. (1976). Comparison of procedures for extracting free amino acids from polymorphonuclear leukocytes. Clin. Chem., 22, 1618
Jellinek, M, Castañeda, M, Garvin, P.J, Nichoff, M. and Codd, J.E. (1985). Oxidation-reduction maintenance in organ preservation. Arch. Surg., 120, 439
Wicomb, W.N, Hill, J.D, Avery, J. and Collins, G.M. (1989). Comparison of cardioplegic and UW solutions for short-term rabbit heart preservation. Transplantation, 47, 733
Cankovic-Darracott, S, Braimbridge, M.V, Williams, B.T, Bitensky, L. and Chayen, J. (1977). Myocardial preservation during aortic valve surgery. J. Thorac. Cardiovasc. Surg., 73, 699
Braimbridge, M.V, Chayen, J, Bitensky, L, Hearse, D.J, Jynge, P. and Canković-Darracott, S. (1977). Cold cardioplegia or continuous coronary perfusion? J. Thorac. Cardiovasc. Surg., 74, 900
Canković-Darracott, S. (1982). In Engelman, R.M. and Levitsky, D. (eds.)A Handbook of Clinical Cardioplegia, p. 43. (New York: Futura)
Bull, C, Cooper, J. and Stark, J. (1984). Cardioplegic protection of the child’s heart. J. Thorac. Cardiovasc. Surg., 88, 287
Chayen, J, Bitensky, L. and Canković-Darracott, S. (1985). Increased myosin orientation during muscle contraction: a measure of cardiac contractility. Cell Biochem. Fund., 3, 101
Canković-Darracott, S, Hutter, J, Wallwork, J, Wheeldon, D. and English, T.A.H. (1988). Biopsy assessment of myocardial preservation in 160 human donor hearts. Transplant. Proc., 20 (5 Suppl. 17), 44
Pitzele, S, Sze, S. and Dobell, A.R.C. (1971). Functional evaluation of the heart after storage under hypothermic coronary perfusion. Surgery, 70, 569.
Levitsky, S, Williams, W.H, Hetmer, D.E, Mcintosh, C.L. and Morrow, A.G. (1970). A functional evaluation of the preserved heart. J. Thorac. Cardiovasc. Surg., 60, 625
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Wicomb, W.N., Cooper, D.K.C. (1990). Storage of the Donor Heart. In: Cooper, D.K.C., Novitzky, D. (eds) The Transplantation and Replacement of Thoracic Organs. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0711-9_7
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