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Immunological Aspects

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The Transplantation and Replacement of Thoracic Organs

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Abstract

When in the early 1980s clinical heart—lung transplantation was reintroduced at Stanford University1, it was assumed that the course of rejection of combined heart—lung transplants was similar to that of isolated cardiac transplants. Furthermore, it was assumed that rejection would occur simultaneously in heart and lungs. These assumptions were based on experimental findings in monkeys2, and seemed to be confirmed by the first clinical observations3, 4. In this perspective, there was no need for specific monitoring of rejection of the lung, because it would be mirrored by the concurrent rejection of the heart; for the detection of heart rejection, endomyocardial biopsy had been proven to be very reliable. With increasing experience, however, it has become evident that cardiac rejection is modulated by the concomitant transplantation of the lungs, and that rejection does not progress simultaneously in heart and lungs.

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Authors
  1. A. L. Westra
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  2. J. Prop
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Editor information

Editors and Affiliations

  1. Baptist Medical Center, Oklahoma Transplantation Institute, Oklahoma City, Oklahoma, USA

    David K. C. Cooper MA, MD, PhD, FRCS (Cardiothoracic Surgeon and Director of Research and Education, Formerly, Associate Professor of Cardiothoracic Surgery) & Dimitri Novitzky MD, FCS (SA) (Cardiothoracic Surgeon, Formerly, Specialist in Cardiothoracic Surgery) (Cardiothoracic Surgeon and Director of Research and Education, Formerly, Associate Professor of Cardiothoracic Surgery) &  (Cardiothoracic Surgeon, Formerly, Specialist in Cardiothoracic Surgery)

  2. University of Cape Town Medical School and Groote Schuur Hospital, Cape Town, South Africa

    David K. C. Cooper MA, MD, PhD, FRCS (Cardiothoracic Surgeon and Director of Research and Education, Formerly, Associate Professor of Cardiothoracic Surgery) (Cardiothoracic Surgeon and Director of Research and Education, Formerly, Associate Professor of Cardiothoracic Surgery)

  3. Groote Schuur Hospital, Cape Town, South Africa

    Dimitri Novitzky MD, FCS (SA) (Cardiothoracic Surgeon, Formerly, Specialist in Cardiothoracic Surgery) (Cardiothoracic Surgeon, Formerly, Specialist in Cardiothoracic Surgery)

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© 1990 Kluwer Academic Publishers

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Westra, A.L., Prop, J. (1990). Immunological Aspects. In: Cooper, D.K.C., Novitzky, D. (eds) The Transplantation and Replacement of Thoracic Organs. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0711-9_39

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  • DOI: https://doi.org/10.1007/978-94-009-0711-9_39

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6805-5

  • Online ISBN: 978-94-009-0711-9

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