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Pathology of Graft Atherosclerosis (Chronic Rejection)

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The Transplantation and Replacement of Thoracic Organs

Abstract

In the two decades since the first human heart transplant was performed by Barnard in 19671, this operation has become a well-established therapy for treating irremediable cardiac failure. Survival rates have progressively improved2, 3 (Chapter 31). In patients who die in the first few months after cardiac transplantation when immunosuppression is maximal, infection is a major cause of death4, 5 (Chapter 17). Rejection is also an important factor which, if not primarily responsible for the patient’s death, contributes significantly to it, even when overwhelming infection is present6, 7. The pattern of acute cardiac rejection, and the role of endomyocardial biopsy in its diagnosis, have been outlined in Chapter 15.

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References

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Authors
  1. A. G. Rose
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  2. C. J. Uys
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Editor information

Editors and Affiliations

  1. Baptist Medical Center, Oklahoma Transplantation Institute, Oklahoma City, Oklahoma, USA

    David K. C. Cooper MA, MD, PhD, FRCS (Cardiothoracic Surgeon and Director of Research and Education, Formerly, Associate Professor of Cardiothoracic Surgery) & Dimitri Novitzky MD, FCS (SA) (Cardiothoracic Surgeon, Formerly, Specialist in Cardiothoracic Surgery) (Cardiothoracic Surgeon and Director of Research and Education, Formerly, Associate Professor of Cardiothoracic Surgery) &  (Cardiothoracic Surgeon, Formerly, Specialist in Cardiothoracic Surgery)

  2. University of Cape Town Medical School and Groote Schuur Hospital, Cape Town, South Africa

    David K. C. Cooper MA, MD, PhD, FRCS (Cardiothoracic Surgeon and Director of Research and Education, Formerly, Associate Professor of Cardiothoracic Surgery) (Cardiothoracic Surgeon and Director of Research and Education, Formerly, Associate Professor of Cardiothoracic Surgery)

  3. Groote Schuur Hospital, Cape Town, South Africa

    Dimitri Novitzky MD, FCS (SA) (Cardiothoracic Surgeon, Formerly, Specialist in Cardiothoracic Surgery) (Cardiothoracic Surgeon, Formerly, Specialist in Cardiothoracic Surgery)

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© 1990 Kluwer Academic Publishers

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Rose, A.G., Uys, C.J. (1990). Pathology of Graft Atherosclerosis (Chronic Rejection). In: Cooper, D.K.C., Novitzky, D. (eds) The Transplantation and Replacement of Thoracic Organs. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0711-9_18

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  • DOI: https://doi.org/10.1007/978-94-009-0711-9_18

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6805-5

  • Online ISBN: 978-94-009-0711-9

  • eBook Packages: Springer Book Archive

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