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Diagnosis and Management of Acute Rejection

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The Transplantation and Replacement of Thoracic Organs

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Abstract

Acute rejection is not a steady phenomenon, but occurs in sporadic waves, extending over a few days or a week or two. Since the introduction of cyclosporine (CsA) as an immunosuppressive agent, severe acute rejection episodes have become relatively rare (seen in less than 2% of endomyocardial biopsies at our center)1. Mild acute rejection (cellular infiltration) is seen fairly frequently, but many groups would not increase therapy in such cases. It is impossible to predict whether or not any individual patient will experience episodes of rejection and, when it occurs, it may be impossible to make the diagnosis on clinical evidence until it is extremely advanced.

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Editors and Affiliations

  1. Baptist Medical Center, Oklahoma Transplantation Institute, Oklahoma City, Oklahoma, USA

    David K. C. Cooper MA, MD, PhD, FRCS (Cardiothoracic Surgeon and Director of Research and Education, Formerly, Associate Professor of Cardiothoracic Surgery) & Dimitri Novitzky MD, FCS (SA) (Cardiothoracic Surgeon, Formerly, Specialist in Cardiothoracic Surgery) (Cardiothoracic Surgeon and Director of Research and Education, Formerly, Associate Professor of Cardiothoracic Surgery) &  (Cardiothoracic Surgeon, Formerly, Specialist in Cardiothoracic Surgery)

  2. University of Cape Town Medical School and Groote Schuur Hospital, Cape Town, South Africa

    David K. C. Cooper MA, MD, PhD, FRCS (Cardiothoracic Surgeon and Director of Research and Education, Formerly, Associate Professor of Cardiothoracic Surgery) (Cardiothoracic Surgeon and Director of Research and Education, Formerly, Associate Professor of Cardiothoracic Surgery)

  3. Groote Schuur Hospital, Cape Town, South Africa

    Dimitri Novitzky MD, FCS (SA) (Cardiothoracic Surgeon, Formerly, Specialist in Cardiothoracic Surgery) (Cardiothoracic Surgeon, Formerly, Specialist in Cardiothoracic Surgery)

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© 1990 Kluwer Academic Publishers

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Cooper, D.K.C. (1990). Diagnosis and Management of Acute Rejection. In: Cooper, D.K.C., Novitzky, D. (eds) The Transplantation and Replacement of Thoracic Organs. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0711-9_16

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  • DOI: https://doi.org/10.1007/978-94-009-0711-9_16

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