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The Transplantation and Replacement of Thoracic Organs pp 115–125Cite as

Pathology of Acute Rejection

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Abstract

Experimental cardiac transplantation using various animals preceded the first human-to-human cardiac transplant in 1967. Such experimental work provided a sound basis for understanding of the clinical and pathological features of cardiac rejection and their modification by immunosuppressive agents. Pioneering experimental work in animals was performed by Carrell and Guthrie1, Mann et al.2, Downie3, Lower et al. 4, and Blumenstock et al.5. Cooper has reviewed the experimental development of cardiac transplantation6 (Chapter 1), and Uys and Rose list key references to the pathology of experimental cardiac transplantation in dogs, rats, rabbits and baboons7. Thomson, in 1968, was the first to describe the pathology of a transplanted human heart8, and this was followed shortly thereafter by the report of Lower et al.9.

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Authors
  1. A. G. Rose
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  2. C. J. Uys
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Editor information

Editors and Affiliations

  1. Baptist Medical Center, Oklahoma Transplantation Institute, Oklahoma City, Oklahoma, USA

    David K. C. Cooper MA, MD, PhD, FRCS (Cardiothoracic Surgeon and Director of Research and Education, Formerly, Associate Professor of Cardiothoracic Surgery) & Dimitri Novitzky MD, FCS (SA) (Cardiothoracic Surgeon, Formerly, Specialist in Cardiothoracic Surgery) (Cardiothoracic Surgeon and Director of Research and Education, Formerly, Associate Professor of Cardiothoracic Surgery) &  (Cardiothoracic Surgeon, Formerly, Specialist in Cardiothoracic Surgery)

  2. University of Cape Town Medical School and Groote Schuur Hospital, Cape Town, South Africa

    David K. C. Cooper MA, MD, PhD, FRCS (Cardiothoracic Surgeon and Director of Research and Education, Formerly, Associate Professor of Cardiothoracic Surgery) (Cardiothoracic Surgeon and Director of Research and Education, Formerly, Associate Professor of Cardiothoracic Surgery)

  3. Groote Schuur Hospital, Cape Town, South Africa

    Dimitri Novitzky MD, FCS (SA) (Cardiothoracic Surgeon, Formerly, Specialist in Cardiothoracic Surgery) (Cardiothoracic Surgeon, Formerly, Specialist in Cardiothoracic Surgery)

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© 1990 Kluwer Academic Publishers

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Rose, A.G., Uys, C.J. (1990). Pathology of Acute Rejection. In: Cooper, D.K.C., Novitzky, D. (eds) The Transplantation and Replacement of Thoracic Organs. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0711-9_15

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  • DOI: https://doi.org/10.1007/978-94-009-0711-9_15

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6805-5

  • Online ISBN: 978-94-009-0711-9

  • eBook Packages: Springer Book Archive

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