Abstract
Dipyridamole is a potent coronary arteriolar vasodilator that has been employed in combination with thallium-201 imaging for the detection of coronary artery disease. Since a coronary stenosis may significantly reduce the regional coronary reserve without inducing ischemia, the presence of coronary artery disease can be documented by the different uptake of a flow tracer, such as thallium-201. Theoretically, myocardial ischemia is not required for the dipyridamole-thallium test to be positive. However, dipyridamole infusion can also induce myocardial ischemia in the presence of a coronary obstruction. This has been shown by a large amount of experimental and clinical evidence [1]. At a dosage of 0.75 mg/kg over 10 min, the electrocardiogram (ECG)-dipyridamole stress test has been proposed for the diagnosis of coronary artery disease, with a diagnostic accuracy comparable to the exercise stress test and an overall sensitivity (ECG changes and/or anginal pain) of about 80% (for a review, see ref [1]).
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References
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Picano, E., Lattanzi, F. (1991). Detection and assessment of the severity of coronary artery disease by dipyridamole echocardiography test. In: Iliceto, S., Rizzon, P., Roelandt, J.R.T.C. (eds) Ultrasound in Coronary Artery Disease. Developments in Cardiovascular Medicine, vol 113. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0611-2_6
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DOI: https://doi.org/10.1007/978-94-009-0611-2_6
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