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Intracoronary blood flow velocity, reactive hyperemia and coronary blood flow reserve during and following PTCA

  • Chapter
Ultrasound in Coronary Artery Disease

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 113))

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Abstract

Since the introduction of percutaneous transluminal coronary angioplasty (PTCA) in 1977 [1], the procedure has gained increasing importance in the treatment of coronary artery obstructions. So far, the immediate results of the procedure have been assessed by coronary angiography and the residual pressure gradient. However, the change in luminal size of an artery following the mechanical disruption of its internal wall cannot be assessed accurately from the detected angiographic contours [2, 3]. The measured residual pressure gradient may have short and long-term prognostic value, but it reflects only the hemodynamic state at rest [4–6] Recently the assessment of coronary flow reserve has been proposed as a better method to evaluate the functional results of dilatation of a coronary artery obstruction [7–10]. Papaverine is currently regarded as the vasodilator of choice for the induction of maximal hyperemia, as intracoronary administration results in an immediate, potent and short-lasting hyperemia [11, 12]. Intracoronary blood flow velocity measurements with a Doppler probe, and the radiographic assessment of myocardial perfusion with contrast media have previously been used to investigate regional coronary flow reserve [13–17]. In the present study we compared both techniques in the setting of PTCA, and compared the pharmacologically induced vasodilation after intracoronary papaverine with reactive hyperemia following transluminal occlusion.

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Authors
  1. Patrick W. Serruys
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  2. Felix Zijlstra
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  3. Hans H. C. Reiber
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  4. Kevin Beatt
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  5. G. J. Laarman
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  6. Jos R. T. C. Roelandt
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  7. P. J. De Feyter
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Editor information

Editors and Affiliations

  1. Department of Cardiology, University of Bari, I-70124, Bari, Italy

    Sabino Iliceto  & Paolo Rizzon  & 

  2. Thorax Center, Erasmus University, P.O. Box 1738, 3000 DR, Rotterdam, The Netherlands

    Jos R. T. C. Roelandt

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© 1991 Kluwer Academic Publishers

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Serruys, P.W. et al. (1991). Intracoronary blood flow velocity, reactive hyperemia and coronary blood flow reserve during and following PTCA. In: Iliceto, S., Rizzon, P., Roelandt, J.R.T.C. (eds) Ultrasound in Coronary Artery Disease. Developments in Cardiovascular Medicine, vol 113. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0611-2_25

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  • DOI: https://doi.org/10.1007/978-94-009-0611-2_25

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6762-1

  • Online ISBN: 978-94-009-0611-2

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