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The continuing story of 5-hydroxytryptamine receptors: a 5-HT3 receptor modulates dopamine release from rat striatal slice

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Book cover Cardiovascular Pharmacology of 5-Hydroxytryptamine

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Abstract

To the large number of 5-HT receptors that have been catalogued [1–4] can now be added the 5-HT1D receptor, first described as a binding site [5] and recently shown to be negatively coupled to adenylyl cyclase in the calf substantia nigra [6]. Yet additional 5-HT receptors exist, not only in mammalian smooth muscles and other peripheral tissues [1, 3] but in brain as well. For example, the hippocampus has binding sites (and probably the homologous receptors) for all known 5-HT receptors [5, 7–10]. But some 5-HT-induced excitatory responses in the hippocampus cannot be attributed to any of these receptors. These include a slow depolarization of pyramidal cells which has been attributed to a decrease in a K+ current [11, 12]; a decrease in the calcium-dependent K+ current responsible for the slow after-spike hyperpolarization in pyramidal cells [11, 12]; and a transient increase in population spike amplitude [13].

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Authors
  1. Patrizio Blandina
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  2. Joseph Goldfarb
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  3. Jack Peter Green
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, Erasmus University, Rotterdam, The Netherlands

    P. R. Saxena

  2. Department of Physiology, University of Wales, College of Cardiff, Cardiff, UK

    D. I. Wallis

  3. Department of Pharmacology, Duphar B.V, Weesp, The Netherlands

    W. Wouters  & P. Bevan  & 

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Blandina, P., Goldfarb, J., Green, J.P. (1990). The continuing story of 5-hydroxytryptamine receptors: a 5-HT3 receptor modulates dopamine release from rat striatal slice. In: Saxena, P.R., Wallis, D.I., Wouters, W., Bevan, P. (eds) Cardiovascular Pharmacology of 5-Hydroxytryptamine. Developments in CardioCardiovascular Pharmacology of 5-Hydroxytryptamine, vol 106. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0479-8_9

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  • DOI: https://doi.org/10.1007/978-94-009-0479-8_9

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