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Agonists and antagonists of 5-HT2 receptors

  • Chapter
Cardiovascular Pharmacology of 5-Hydroxytryptamine

Abstract

In the context of an update on new drugs used in the characterization of functional receptors for 5-hydroxytryptamine (5-HT), a review such as this on 5-HT2 receptor agonists and antagonists needs to address the criteria currently used to classify these receptors, and to consider the validity of these criteria in the light of the relevant data available on functional actions. In particular, any evidence suggesting heterogeneity within this functional receptor classification needs to be evaluated, thus quantitative functional data obtained in vitro for several 5-HT2 receptor antagonists in a range of tissues containing 5-HT2 receptors have been considered in some detail. Comparisons have also been made with data obtained in ligand binding studies. The question of specificity has also been briefly considered, and some recently developed 5-HT2 receptor agonists and antagonists have been discussed.

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Authors
  1. E. J. Mylecharane
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Editors and Affiliations

  1. Department of Pharmacology, Erasmus University, Rotterdam, The Netherlands

    P. R. Saxena

  2. Department of Physiology, University of Wales, College of Cardiff, Cardiff, UK

    D. I. Wallis

  3. Department of Pharmacology, Duphar B.V, Weesp, The Netherlands

    W. Wouters  & P. Bevan  & 

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Mylecharane, E.J. (1990). Agonists and antagonists of 5-HT2 receptors. In: Saxena, P.R., Wallis, D.I., Wouters, W., Bevan, P. (eds) Cardiovascular Pharmacology of 5-Hydroxytryptamine. Developments in CardioCardiovascular Pharmacology of 5-Hydroxytryptamine, vol 106. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0479-8_7

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  • DOI: https://doi.org/10.1007/978-94-009-0479-8_7

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