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The human platelet 5-HT2-receptor: an up-date

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Cardiovascular Pharmacology of 5-Hydroxytryptamine

Abstract

Platelets are oval discs 2 to 3 μm in diameter, circulating in the blood. They can adhere to damaged blood vessel walls (adhesion) and stick to each other (aggregation). Platelets contain α -granules, dense bodies, lysosomes, mitochondria and glycogen particles. Three different channel-like structures have been identified: an open canalicular system, a dense tubular system and circumferential microtubules. The platelet plasma membrane resembles, in structure as well as in function, that of cells of other tissue. In the sub-membrane area, platelets have microtubules which support their discoid shape and microfilaments which contain contractile proteins involved in the platelet release reaction. Such a release reaction is provoked by platelet stimulation with excitatory agonists. This results in the appearance in the extracellular space of the content of the granules, the dense bodies and the lysosome-like particles. The α -granules contain secretable platelet proteins, such as fibrinogen, β - thromboglobulin, platelet factor-4 and cationic proteins. The dense bodies mainly contain ATP, ADP, calcium and serotonin. The lysosome-like particles contain acid hydrolases. The extent of secretion of the contents of these different subcellular particles depends upon the nature and the concentration of the challenging agonist. Platelets also biosynthetize and release metabolites from arachidonic acid (see also section 1.2).

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Authors
  1. D. de Chaffoy de Courcelles
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  2. F. de Clerck
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, Erasmus University, Rotterdam, The Netherlands

    P. R. Saxena

  2. Department of Physiology, University of Wales, College of Cardiff, Cardiff, UK

    D. I. Wallis

  3. Department of Pharmacology, Duphar B.V, Weesp, The Netherlands

    W. Wouters  & P. Bevan  & 

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© 1990 Springer Science+Business Media Dordrecht

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de Chaffoy de Courcelles, D., de Clerck, F. (1990). The human platelet 5-HT2-receptor: an up-date. In: Saxena, P.R., Wallis, D.I., Wouters, W., Bevan, P. (eds) Cardiovascular Pharmacology of 5-Hydroxytryptamine. Developments in CardioCardiovascular Pharmacology of 5-Hydroxytryptamine, vol 106. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0479-8_39

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  • DOI: https://doi.org/10.1007/978-94-009-0479-8_39

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6701-0

  • Online ISBN: 978-94-009-0479-8

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