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The endothelium and the role of 5-hydroxytryptamine in vascular disease

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Cardiovascular Pharmacology of 5-Hydroxytryptamine

Abstract

The vascular actions of 5-hydroxytryptamine (5-HT), originally named serotonin [1], remain difficult to understand, as it causes varying responses depending on the isolated blood vessel or vascular bed studied, or the experimental conditions imposed. The present essay will summarize some of the experiments performed in the author’s laboratory suggesting that the presence of the endothelium helps to determine if the monoamine causes constriction or dilatation of blood vessels. In particular, the emerging role of endothelium-derived vasoactive factors in the mediation of the vascular effects of 5-HT will be addressed. For details and original references not cited here the reader is referred to several earlier reviews on related topics [2–17],

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Authors
  1. Paul M. Vanhoutte
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Editors and Affiliations

  1. Department of Pharmacology, Erasmus University, Rotterdam, The Netherlands

    P. R. Saxena

  2. Department of Physiology, University of Wales, College of Cardiff, Cardiff, UK

    D. I. Wallis

  3. Department of Pharmacology, Duphar B.V, Weesp, The Netherlands

    W. Wouters  & P. Bevan  & 

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© 1990 Springer Science+Business Media Dordrecht

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Vanhoutte, P.M. (1990). The endothelium and the role of 5-hydroxytryptamine in vascular disease. In: Saxena, P.R., Wallis, D.I., Wouters, W., Bevan, P. (eds) Cardiovascular Pharmacology of 5-Hydroxytryptamine. Developments in CardioCardiovascular Pharmacology of 5-Hydroxytryptamine, vol 106. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0479-8_33

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  • DOI: https://doi.org/10.1007/978-94-009-0479-8_33

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6701-0

  • Online ISBN: 978-94-009-0479-8

  • eBook Packages: Springer Book Archive

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