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Receptors for 5-hydroxytryptamine in the cardiovascular system

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Cardiovascular Pharmacology of 5-Hydroxytryptamine

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Abstract

5-Hydroxytryptamine (5-HT; serotonin) receptor characterization has revealed three broad classes of receptors: 5-HT1, 5-HT2, and 5-HT3 [1, 2]. At least four subtypes of the 5-HT1 receptor exist: 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D. The suggestion has been made that 5-HT3 receptors may also be heterogeneous; however, general consensus in this regard has not been achieved. Although the precise number of 5-HT receptors is controversial (due to limitations and specificity of drugs used to study these receptors), it is clear that many of the receptors identified in brain membrane binding studies also exist within the cardiovascular system.

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Authors
  1. Marlene L. Cohen
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Editors and Affiliations

  1. Department of Pharmacology, Erasmus University, Rotterdam, The Netherlands

    P. R. Saxena

  2. Department of Physiology, University of Wales, College of Cardiff, Cardiff, UK

    D. I. Wallis

  3. Department of Pharmacology, Duphar B.V, Weesp, The Netherlands

    W. Wouters  & P. Bevan  & 

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© 1990 Springer Science+Business Media Dordrecht

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Cohen, M.L. (1990). Receptors for 5-hydroxytryptamine in the cardiovascular system. In: Saxena, P.R., Wallis, D.I., Wouters, W., Bevan, P. (eds) Cardiovascular Pharmacology of 5-Hydroxytryptamine. Developments in CardioCardiovascular Pharmacology of 5-Hydroxytryptamine, vol 106. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0479-8_22

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  • DOI: https://doi.org/10.1007/978-94-009-0479-8_22

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6701-0

  • Online ISBN: 978-94-009-0479-8

  • eBook Packages: Springer Book Archive

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