Skip to main content
SpringerLink
Log in

Cardiovascular reflexes and 5-hydroxytryptamine

  • Chapter
Cardiovascular Pharmacology of 5-Hydroxytryptamine

Abstract

The effects of 5-hydroxytryptamine (5-HT) on the cardiovascular system are complex and very variable [1], which is not surprising given that the amine can act directly on specific 5-HT receptors in the heart and blood vessels, inhibit transmitter release from adrenergic nerves, amplify the activity of mediators on vascular smooth muscle, displace noradrenaline from adrenergic nerve terminals, release endothelium-dependent relaxant factor(s), facilitate platelet aggregation, and, in addition, can also activate sensory receptors in the cardiopulmonary system and carotid bifurcation, thereby reflexly affecting the cardiovascular system [2, 3, 4]. This chapter focuses on certain sensors that are activated by 5-HT to cause reflex cardiovascular changes, and reviews what is known about the type(s) of 5-HT receptor involved in evoking these reflexes.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Page IH, McCubbin JW (1953): The variable arterial pressure response to serotonin in laboratory animals and man. Circ Res 1: 354–362.

    Article  CAS  PubMed  Google Scholar 

  2. Paintal AS (1955): Impulses in vagal afferent fibres from specific pulmonary deflation receptors. The response of these receptors to phenyl diguanide, potato starch, 5-hydroxytryptamine and nicotine, and their role in respiratory and cardiovascular reflexes. Q J Exp Physiol 40: 89–111.

    CAS  PubMed  Google Scholar 

  3. Paintal AS (1973): Sensory mechanisms involved in the Bezold-Jarisch reflex. Australian J Exp Biol & Med Sci 51:3–15.

    Article  CAS  Google Scholar 

  4. Hollenberg NK (1988): Serotonin and vascular responses. Ann Rev Pharmacol Toxicol 28: 41–59.

    Article  CAS  Google Scholar 

  5. Page IH (1952): The vascular action of natural serotonin, 5- and 7-hydroxytryptamine and tryptamine. J Pharmacol Exp Ther 105: 58–73.

    CAS  PubMed  Google Scholar 

  6. Salmoiraghi GC, Page IH, McCubbin JW (1956): Cardiovascular and respiratory response to intravenous serotonin in rats. J Pharmacol Exp Ther 118: 477–481.

    CAS  PubMed  Google Scholar 

  7. Black AMS, Comroe JH Jr, Jacobs L (1972): Species difference in carotid body response of cat and dog to dopamine and serotonin. Am J Physiol 223: 1097–1102.

    CAS  PubMed  Google Scholar 

  8. Daly M de B (1985): Chemoreceptor reflexes and cardiovascular control. Acta Physiol Pol 36: 4–20.

    Google Scholar 

  9. Heymans C, Neil E (1958): ‘Reflexogenic areas of the cardiovascular system’, pp. 271. London, Churchill.

    Google Scholar 

  10. Ginzel KH (1975): The importance of sensory nerve endings as sites of drug action. NS Arch Pharmacol 288: 29–56.

    Article  CAS  Google Scholar 

  11. Mancia G, Lorenz RR, Shepherd JT (1976): Reflex control of circulation by heart and lungs. Inter Rev Physiol Cardiovascular Physiol 11 9:111–144.

    Google Scholar 

  12. Paintal AS (1977): Effects of drugs on chemoreceptors, pulmonary and cardiovascular receptors. Pharmac Ther Bull 3: 41–63.

    CAS  Google Scholar 

  13. Donald DE, Shepherd JT (1978): Reflexes from the heart and lungs: physiological curiosities or important regulatory mechanisms. Cardiovasc Res 12: 446–469.

    Article  CAS  PubMed  Google Scholar 

  14. Thoren P (1979): Role of cardiac vagal C-fibres in cardiovascular control. Rev Physiol Biochem Pharmacol 86: 1–94.

    Article  CAS  PubMed  Google Scholar 

  15. Dawes GS, Mott JC, Widdicombe JG (1951): Respiratory and cardiovascular reflexes from the heart and lungs. J Physiol 115: 258–291.

    CAS  PubMed  Google Scholar 

  16. Ginzel KH (1958): The effects of 5-hydroxytryptamine on peripheral receptors of cardiovascular and respiratory reflexes, pp. 131–135 in: Lewis GP (ed.), 5-Hydroxytryptamine. London: Pergamon.

    Google Scholar 

  17. Richardson BP, Engel G, Donatsch P, Stadler PA (1985): Identification of serotonin M-receptor subtypes and their specific blockade by a new class of drugs. Nature 316: 126 - 131.

    Article  CAS  PubMed  Google Scholar 

  18. Richardson BP, Engel G (1986): The pharmacology and function of 5-HT3 receptors. Trends in Neurosci 9: 424–428.

    Article  CAS  Google Scholar 

  19. Bradley PB, Engel G, Feniuk W, Fozard JR, Humphrey PPA, Middlemiss DN, Mylencharane EJ, Richardson BP, Saxena PR (1986): Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine. Neuropharmacol 25: 563 - 576.

    Article  CAS  Google Scholar 

  20. Nishi K (1975): The action of 5-hydroxytryptamine on chemoreceptor discharges of the cat’s carotid body. Br J Pharmacol 55: 27–40.

    Article  CAS  PubMed  Google Scholar 

  21. Sapru HN, Krieger AJ (1977): Effect of 5-hydroxytryptamine on the peripheral chemoreceptors in the rat. Res Comm Chem Path Pharmacol 16: 245–250.

    CAS  Google Scholar 

  22. Sapru HN, Krieger AJ (1977): Carotid and aortic chemoreceptor function in the rat. J Appl Physiol 42: 344–348.

    CAS  PubMed  Google Scholar 

  23. Chiocchio SR, Biscardi AM, Tramezzani JH (1967): 5-Hydroxytryptamine in the carotid body of the cat. Science 158:790–791.

    Article  CAS  PubMed  Google Scholar 

  24. McQueen DS, Mir AK (1984): Changes in carotid body amine levels and effects of dopamine on rats treated neonatally with capsaicin. Br J Pharmacol 83: 909–918.

    Article  CAS  PubMed  Google Scholar 

  25. Gronblad M, Liesi P, Rechardt L (1983): Serotonin-like immunoreactivity in rat carotid body. Brain Res 276: 348–350.

    Article  CAS  PubMed  Google Scholar 

  26. Perrin DG, Chan W, Cutz E, Madapallimattam A, Sole MJ (1986): Serotonin in human infant carotid body. Experientia 42: 562–564.

    Article  CAS  PubMed  Google Scholar 

  27. McQueen DS (1983): Pharmacological aspects of putative transmitters in the carotid body, pp. 149–196 in: Acker H, O’Regan RG (ed.), Physiology of the peripheral arterial chemoreceptors. Amsterdam: Elsevier.

    Google Scholar 

  28. McQueen DS, Ungar A (1971): On the direct and crossed components of reflex responses to stimulation of the carotid body chemoreceptors in the dog. J Physiol 219: 1–16.

    CAS  PubMed  Google Scholar 

  29. Skinner SL, Whelan RF (1962): Carotid body stimulation by 5-hydroxytryptamine in man. J Physiol 162: 35–43.

    CAS  PubMed  Google Scholar 

  30. Bisgard GE, Mitchell RA, Herbert DA (1979): Effects of dopamine, norepinephrine and 5-hydroxytryptamine on the carotid body of the dog. Resp Physiol 37: 61–80.

    Article  CAS  Google Scholar 

  31. Kirby GC, McQueen DS (1984): Effects of the antagonists MDL 72222 and ketanserin on responses of cat carotid body chemoreceptors to 5-hydroxytryptamine. Br J Pharmacol 83: 259–269.

    Article  CAS  PubMed  Google Scholar 

  32. Eyzaguirre C, Koyano H (1965): The effects of some pharmacological agents on chemoreceptor discharges. J Physiol 178: 410–437.

    CAS  PubMed  Google Scholar 

  33. Yoshioka M, Matsumoto M, Togashi H, Abe M, Tochihara M, Saito H (1987): The 5-hydroxytryptamine-induced increase in chemoreceptor afferent nerve discharge and its blockade by ICS 205-930 in the rat. Res Comm Psych Psych & Behaviour 12: 215–220.

    CAS  Google Scholar 

  34. Kirby GC, McQueen DS (1985): Effects of selective 5-hydroxytryptamine agonists on carotid body chemoreceptor discharge in anaesthetized cats. Br J Pharmac 86: 733 P.

    Google Scholar 

  35. McQueen DS, Mir AK (1988): Involvement of 5-HT3 receptors in responses of cat carotid body chemoreceptors to phenylbiguanide. J Physiol 401: 86 P.

    Google Scholar 

  36. Scholtysik G. (1987): Evidence for inhibition by ICS 205–930 and stimulation by BRL 34915 of K+ conductance in cardiac muscle. N-S. Arch. Pharmacol 335: 692–696.

    Article  CAS  Google Scholar 

  37. Verberne AJM, Costa M, Lewis SJ, Louis WJ, Beart PM (1987): The N-Methyl-D-aspartate (NMDA) receptor antagonist MK-801, attenuates the Bezold-Jarisch reflex in the anaesthetized rat. Neuropharmacology 26: 1243–6.

    Article  CAS  PubMed  Google Scholar 

  38. Fortune DH, Ireland SJ, Tyers MB (1983): Phenylbiguanide minics the effects of 5-hydroxytryptamine on the rat isolated vagus nerve and superior cervical ganglion. Br J Pharmacol 79: 298 P.

    Google Scholar 

  39. Collins DP, Fortune DH (1983): Phenylbiguanide mimics the Bezold-Jarisch effect of 5-HT in the rat. Br J Pharmac 80: 570 P.

    Google Scholar 

  40. Fozard JR (1984): MDL 72222: a potent and highly selective antagonist at neuronal 5-hydroxytryptamine receptors. N-S Arch Pharmacol 326: 36–44.

    Article  CAS  Google Scholar 

  41. Richardson BP, Engel G, Dontasch P, Stadler PA (1985): Identification of serotonin M-receptor subtypes and their specific blockade by a new class of drugs. Nature 316: 126–131.

    Article  CAS  PubMed  Google Scholar 

  42. Ireland SJ, Tyers MB (1987): Pharmacological characterisation of 5-hydroxytryptamine- induced depolarization of the rat isolated vagus nerve. BrJPharmac 90: 229–238.

    Article  CAS  Google Scholar 

  43. Paintal AS (1986): The significance of dry cough, breathlessness and muscle weakness. IndJ Tuberculosis 33: 51–55.

    Google Scholar 

  44. Armstrong DJ, Kay IS, Russell NJW (1986): The pulmonary chemoreflexes evoked by phenylbiguanide, diguanide and guanide. J Physiol 371: 115 P.

    Google Scholar 

  45. Armstrong DJ, Kay IS, Russell NJW (1986): MDL 72222 antagonizes the reflex tachypneoic response to miliary pulmonary embolism in anaesthetized rabbits. J Physiol 381: 13 P.

    Google Scholar 

  46. Sapru HN, Willette RN, Krieger AJ (1981): Stimulation of pulmonary J receptors by an enkephalin analog. J Pharm Exp Ther 217: 228–234.

    CAS  Google Scholar 

  47. Sicuteri F (1983): Is acute tolerance to 5-hydroxytryptamine opioid dependent? Its absence in migraine sufferers. Cephalagia 3: 187–190.

    Article  CAS  Google Scholar 

Download references

Authors
  1. Daniel S. McQueen
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Pharmacology, Erasmus University, Rotterdam, The Netherlands

    P. R. Saxena

  2. Department of Physiology, University of Wales, College of Cardiff, Cardiff, UK

    D. I. Wallis

  3. Department of Pharmacology, Duphar B.V, Weesp, The Netherlands

    W. Wouters  & P. Bevan  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

McQueen, D.S. (1990). Cardiovascular reflexes and 5-hydroxytryptamine. In: Saxena, P.R., Wallis, D.I., Wouters, W., Bevan, P. (eds) Cardiovascular Pharmacology of 5-Hydroxytryptamine. Developments in CardioCardiovascular Pharmacology of 5-Hydroxytryptamine, vol 106. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0479-8_17

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-0479-8_17

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6701-0

  • Online ISBN: 978-94-009-0479-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation