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5-Hydroxytryptaminergic neurotransmission in the gut

  • Chapter
Cardiovascular Pharmacology of 5-Hydroxytryptamine

Abstract

The enteric nervous system (ENS) is quite different in structure, complexity, organization, and function from other divisions of the autonomic nervous system (for reviews see [1–3]). Unlike the sympathetic and parasympathetic divisions, most enteric neurons receive no direct innervation from the central nervous system (CNS). Despite this relative lack of input from the CNS, the ENS can mediate reflex activity. To have this capability, the ENS must contain intrinsic primary afferent neurons, a variety of interneurons, and motor neurons. Thus, enteric ganglia cannot be considered to be simple relays. In addition, like the CNS, the ENS has many different types of neuron, defined either by established or putative neurotransmitter content or by shape. This complexity must be borne in mind when interpreting the effects of neuroactive compounds on the gastrointestinal tract.

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Authors
  1. Michael D. Gershon
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  2. Gary M. Mawe
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  3. Theresa A. Branchek
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, Erasmus University, Rotterdam, The Netherlands

    P. R. Saxena

  2. Department of Physiology, University of Wales, College of Cardiff, Cardiff, UK

    D. I. Wallis

  3. Department of Pharmacology, Duphar B.V, Weesp, The Netherlands

    W. Wouters  & P. Bevan  & 

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Gershon, M.D., Mawe, G.M., Branchek, T.A. (1990). 5-Hydroxytryptaminergic neurotransmission in the gut. In: Saxena, P.R., Wallis, D.I., Wouters, W., Bevan, P. (eds) Cardiovascular Pharmacology of 5-Hydroxytryptamine. Developments in CardioCardiovascular Pharmacology of 5-Hydroxytryptamine, vol 106. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0479-8_15

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  • DOI: https://doi.org/10.1007/978-94-009-0479-8_15

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6701-0

  • Online ISBN: 978-94-009-0479-8

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