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Positron Emission Tomography in Partial Epilepsy

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Clinical PET

Part of the book series: Developments in Nuclear Medicine ((DNUM,volume 28))

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Abstract

Uncontrolled partial epilepsy is an important medical problem. It can be surgically treated if the site of seizure onset, the epileptic focus, can be delimited and removed. Up to recently, accurate identification of the epileptogenic area relied solely upon sophisticated and time-consuming extra- and intracranial EEG recording techniques, even though EEG occasionnally may fail in providing the localization of the focus due to the rapid propagation of the electrical discharges.

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References

  1. Kuhl, D.E., Engel, J. Jr, Phelps, M.E., Selin, C. Epileptic patterns of local cerebral metabolism and perfusion in humans determined by emission computed tomography of 18FDG and 13NH3. Ann. Neurol. 1980; 8: 348–360.

    Article  PubMed  CAS  Google Scholar 

  2. Abou-Khalil, B.W., Siegel, G.J., Sackellares, J.C., Gilman, S., Hichwa, R., Marshall, R. Positron emission tomography studies of cerebral glucose metabolism in chronic partial epilepsy. Ann. Neurol. 1987; 22: 480–486.

    Article  PubMed  CAS  Google Scholar 

  3. DeLaPena, R., Perlman, S.B., Levine, R., Kanner, A.M., Jones, J.J., Pyzalski, R., Nickles, R.J. PET scan findings in patients with temporal lobe epilepsy of mesial temporal origin. J. Nucl. Med. 1992; 33: 1014.

    Google Scholar 

  4. Engel, J., Jr, Henry, T.R., Risinger, M.W., Mazziotta, J.C., Sutherling, W.W., Levesque, M.F., Phelps, M.E. Presurgical evaluation for partial epilepsy: relative contribution of chronic depth-electrode recordings versus FDG-PET and scalp-sphenoidal ictal EEG. Neurology 1990; 40: 1670–1677.

    PubMed  Google Scholar 

  5. Engel, J., Jr, Kuhl, D.E., Phelps, M.E., Crandall, P.H. Comparative localization of epileptic foci in partial epilepsy by PCT and EEG. Ann. Neurol. 1982a; 12: 529–537.

    Article  Google Scholar 

  6. Engel, J., Jr, Kuhl, D.E., Phelps, M.E., Mazziotta, J.C. Interictal cerebral glucose metabolism in partial epilepsy and its relation to EEG changes. Ann. Neurol. 1982b; 12: 510–517.

    Article  Google Scholar 

  7. Ryvlin, P., Cinotti, L., Froment, J.C., Le Bars, D., Landais, P., Chaze, M., Galy, G., Lavenne, F., Serra, J.P., Mauguière, F. Metabolic patterns associated with nonspecific magnetic resonance imaging abnormalities in temporal lobe epilepsy. Brain 1991; 114: 2363–2383.

    Article  PubMed  Google Scholar 

  8. Sackellares, J.C., Siegel, G.J., Abou-Khalil, B.W., Hood, T.W., Gilman, S., McKeever, P.E., Hichwa, R.D., Hutchins, G.D. Differences between lateral and mesial temporal metabolism interictally in epilepsy of mesial temporal origin. Neurology 1990; 40: 1420–1426.

    PubMed  CAS  Google Scholar 

  9. Sadzot, B., Debets, R.M., Maquet, P., van Veelen, C.W., Salmon, E., van Emde Boas, W., Velis, D.N., van Huffelen, A.C., Franck, G. Regional brain glucose metabolism in patients with complex partial seizures investigated by intracranial EEG. Epilepsy Res. 1992; 12: 121–129.

    Article  PubMed  CAS  Google Scholar 

  10. Theodore, W.H., Newmark, M.E., Sato, S., Brooks, R., Patronas, N., De La Paz, R., DiChiro, G., Kessler, R.M., Margolin, R., Manning, R.G., Channing, M., Porter, R.J. [18F]fluorodeoxyglucose positron emission tomography in refractory complex partial seizures. Ann. Neurol. 1983; 14: 429–437.

    Article  PubMed  CAS  Google Scholar 

  11. Swartz, B.E., Tomiyasu, U., Delgado-Escueta, A.V., Mandelkern, M., Khonsari, A. Neuroimaging in temporal lobe epilepsy: test sensitivity and relationships to pathology and post-operative outcome. Epilepsia 1992; 33: 624–634.

    Article  PubMed  CAS  Google Scholar 

  12. Hajek, M., Antonini, A., K.L. Leenders, Wieser, H.G. Mesiobasal versus lateral temporal lobe epilepsy: metabolic differences in the temporal lobe shown by interictal 18F-FDG positron emission tomography. Neurology 1993; 43: 79–86.

    PubMed  CAS  Google Scholar 

  13. Henry, T.R., Sutherling, W.W., Engel, J. Jr, Risinger, M.W., Levesque, M.F., Mazziotta, J.C., Phelps, M.E. Interictal cerebral metabolism in partial epilepsics of ncocortical origin. Epilepsy Res. 1991; 10: 174–182.

    Article  PubMed  CAS  Google Scholar 

  14. Radtke, R.A., Coleman, R.E., Hanson, M.W., Walczak, T.S., Lewis, D.V., McNamara, J.O. Positron emission tomography in extratemporal epilepsy. Neurology 1989; 39 (Suppl. 1): 301.

    Google Scholar 

  15. Swartz, B.E., Halgren, E., Delgado-Escueta, A.V., Mandelkern, M., Gee, M., Quinones, N., Bland, W.H., Repchan, J. Neuroimaging in patients with seizures of probable frontal lobe origin. Epilepsia 1989; 30: 547–558.

    Article  PubMed  CAS  Google Scholar 

  16. Franceschi, M., Messa, C., Ferini-Strambi, L., Lucignani, G., Canal, N., Lenzi, G.L., Fazio, F. SPECT imaging of cerebral perfusion in patients with non-refractory temporal lobe epilepsy. Acta Neurol. Scand. 1993; 87: 268–74.

    Article  PubMed  CAS  Google Scholar 

  17. Newton, M.R., Berkovic, S.F., Austin, M.C., Rowe, C.C., McKay, W.J., Bladin, P.F. Postictal switch in blood flow distribution and temporal lobe seizures.. J. Neurol. Neurosurg. Psychiat. 1992; 55: 891–894.

    Article  PubMed  CAS  Google Scholar 

  18. Rowe, C.C., Berkovic, S.F., Sia, S.T.B., Austin, M., McKay, W.J., Klanius, R.M., Bladin, P.F. Localization of epileptic foci with postictal single photon emission computed tomography. Ann. Neurol. 1989; 26: 660–668.

    Article  PubMed  CAS  Google Scholar 

  19. Ryvlin, Ph., Philippon, B., Cinotti, L., Froment, J.C., Le Bars, D., Maugiuère, F. Functional neuroimaging strategy in temporal lobe epilepsy: a comparative study of 18FDG-PET and 99mTc-HMPAO-SPECT. Ann. Neurol. 1992; 31: 650–656.

    Article  PubMed  CAS  Google Scholar 

  20. Rowe, C.C., Berkovic, S.F., Austin, M.C., Saling, M., Kalnins, R.M., McKay, W.J., Bladin, P.F. Visual and quantitative analysis of interictal SPECT with technetium99m-HMPAO in temporal lobe epilepsy. J. Nucl. Med. 1991; 32: 1688–1991.

    CAS  Google Scholar 

  21. Stefan, H., Pawlik, G., Böcher-Schwarz, H.G., Biersack, H.J., Burr, W., Penin, H., Heiss, W.D. Functional and morphological abnormalities in temporal lobe epilepsy: a comparison of interictal and ictal EEG, CT, MRI, SPECT and PET. J. Neurol. 1987; 234: 377–384.

    Article  PubMed  CAS  Google Scholar 

  22. Duncan, R., Patterson, J., Roberts, R., Hadley, D.M., Bone I. Ictal/postictal SPECT in the pre-surgical localisation of complex partial seizures.. J. Neurol. Neurosurg. Psychiat. 1993; 56: 141–148.

    Article  PubMed  CAS  Google Scholar 

  23. Cordes, M., Henkes, H., Ferstl, F., Schmitz, B., Hierholzer, J., Schmidt, D., Felix, R. Evaluation of focal epilepsy: a SPECT scanning comparison of 123-I-iomazenil versus HM-PAO. Am. J. Neuroradiol. 1992; 13: 249–253.

    PubMed  CAS  Google Scholar 

  24. van Huffelen, A.C., van Isselt, J.W., van Veelen, C.W., van Rijk, P.P., van Bentum, A.M., Dive, D., Maquet, P., Franck, G., Velis, D.N., van Emde Boas, W., Debets, R.M. Identification of the side of epileptic focus with 1231-lomazenil SPECT. A comparison with 18FDG-PET and ictal EEG findings in patients with medically intractable complex partial seizures. Acta Neurochir. 1990; Supplcmcntum 50: 95–99.

    Google Scholar 

  25. Müller-Gärtner, H.W., Mayberg, H.S., Fisher, R.S., Lesser, R.P., Wilson, A.A., Raven, H.T., Dannals, R.F., Wagner, H.N. Jr., Uematsu, S., Frost, J.J. Decreased hippocampal muscarinic cholinergic receptor binding measured by 123 1iododexetimide and single-photon emission computed tomography in epilepsy. Ann. Neurol. 1993; 34: 235–238.

    Article  PubMed  Google Scholar 

  26. Bemardi, S., Trimble, M.R., Frackowiak, R.S.J., Wise, R.J.S., Jones, T. An interictal study of partial epilepsy using positron emission tomography and the oxygen-15 inhalation technique. J. Neurol. Neurosurg. Psychiat. 1983; 46: 473–477.

    Article  Google Scholar 

  27. Franck, G., Sadzot, B., Salmon, E., Depresseux, J.C., Grisar, T., Peters, J.M., Quaglia, L., Delfiore, G., Lamotte, D., Regional blood flow and metabolic rates in human focal epilepsy and status epilepticus. In: “Advances in Neurology: Basic Mechanisms of the Epilepsies”, Vol 44, edited by A.V. Delgado-Escueta, Ward, A.A., Jr., D.M. Woodbury, and R.J. Porter. Raven Press, New York 1986;pp:935–948.

    Google Scholar 

  28. Leiderman, D.B., Balish, M., Sato, S., Kufta, C., Reeves, P., Gaillard, W.D., Theodore, W.H. Comparison of PET measurements of cerebral blood flow and glucose metabolism for the localization of human epileptic foci. Epilepsy Res. 1992; 13: 153–157.

    Article  PubMed  CAS  Google Scholar 

  29. Frost, J.J., Mayberg, H.S., Fisher, R.S., Douglass, K.H., Dannals, R.F., Links, J.M., Wilson, A.A., Ravert, H.T., Rosenbaum, A.E., Snyder, S.H., Wagner, H.N., Jr. Mu-opiate receptors measured by positron emission tomography are increased in temporal lobe epilepsy. Ann. Neurol. 1988; 23: 231–237.

    Article  PubMed  CAS  Google Scholar 

  30. Mayberg, H.S., Sadzot, B., Cidis Meltzer, C.C., Fisher, R.S., Lesser, R.P., Dannals, R.F., Lever, J.R., Wilson, A.A., Ravert, H. T., Wagner, H.N., Jr, Bryan, R.N., Cromwell, C.C., Frost, J.J. Quantification of mu and non-mu opiate receptors in temporal lobe epilepsy using positron emission tomography. Ann. Neurol. 1991; 30: 3–11.

    Article  PubMed  CAS  Google Scholar 

  31. Theodore, W.H., Carson, R.E., Andreasen, P., Zametkin, A., Blasberg, R., Leiderman, D.B., Rice, K., Newman, A., Channing, M., Dunn, B., Simpson, N., Herscovitch, P. PET imaging of opiate receptor binding in human epilepsy using [18F]cyclofoxy. Epilepsy Res. 1992; 13: 129–139.

    Article  PubMed  CAS  Google Scholar 

  32. Persson, A., Ehrin, E., Eriksson, L., Farde, L., Hedström, C-G., Litton, J.-E., Mindus, P., Sedvall, G. Imaging of [11C]-labelled Ro 15–1788 binding to benzodiazepine receptors in the human brain by positron emission tomography. J. Psychiat. Res. 1985; 19: 609–622.

    Article  PubMed  CAS  Google Scholar 

  33. Samson, Y., Hantraye, P., Baron, J.C., Soussaline, F., Comar, D., Mazière, M. Kinetics and displacement of [11C]Ro 15–1788, a benzodiazepine antagonist, studied in human brain in vivo by positron emission tomography. Eur. J. Pharmacol. 1985; 110: 247–251.

    Article  PubMed  CAS  Google Scholar 

  34. Savic, I., Persson, A., Roland, P., Pauli, S., Sedvall, G., Widen, L. In vivo demonstration of reduced benzodiazepine receptor binding in human epileptic foci. Lancet 1988; 2: 863–866.

    Article  PubMed  CAS  Google Scholar 

  35. Henry, T.R., Frey, K.A., Sackellares, J.C., Gilman, S., Koeppe, R.A., Brunberg, J.A., Ross, D.A., Berent, S., Young, A.B., Kuhl, D. In vivo cerebral metabolism and central benzodiazepine-receptor binding in temporal lobe epilepsy. Neurology 1993; 43: 1998–2006.

    PubMed  CAS  Google Scholar 

  36. Sadzot, B., Debets, R.M., Delfiore, G., van Huffelen, C.W., van Veelen, A.C., Degueldre, C, Comar, D., Franck, G. Decrease of 11C-flumazenil binding is more localized than glucose hypometabolism in patients with TLE studied by PET. Neurology 1994; 44 (Suppl. 2): A351 - A352.

    Google Scholar 

  37. Savic, I., Ingvar, M., Stone-Elander, S. Comparison of [11C]flumazenil and [18F]FDG as PET markers of epileptic foci. J. Neurol. Neurosurg. Psychiat. 1993; 56: 615–621.

    Article  PubMed  CAS  Google Scholar 

  38. Syapin, P.J., Skolnick, P. Characterization of benzodiazepine binding sites in cultured cells of neuronal origin. J. Neurochem. 1979; 32: 1047–1051.

    Article  PubMed  CAS  Google Scholar 

  39. Zavala, F., Lenfant, M. Benzodiazepines and PK 11195 exert immunomodulating activities by binding on a specific receptor on macrophage. Ann. NY Acad. Sci. 1987; 496: 240–249.

    Article  PubMed  CAS  Google Scholar 

  40. Benavides, J., Cornu, P., Dennis, T., Dubois, A., Hauw, J.J., MacKenzie, Sazdovitch, V., Scatton, B., Imaging of human brain lesions with an omega 3 site radioligand. Ann. Neurol. 1988; 24: 708–712.

    Article  PubMed  CAS  Google Scholar 

  41. Junck, L., Olson, J.M., Ciliax, B.J., Koeppe, R.A., Watkins, G.L., Jewett, D.M., McKeever, P.E., Wieland, D.M., Kilbourn, M.R., Starosta-Rubinstein, S., Mancini, W.R., Kuhl, D.E., Greenberg, H.S., Young, A.B. PET imaging of human gliomas with ligands for the peripheral benzodiazepine binding site. Ann. Neurol. 1989;26:752–758.

    Article  PubMed  CAS  Google Scholar 

  42. Kumlien, E., Hilton-Brown, P., Spännare, B., Gillberg, P.G. In vitro quantitative autoradiography of [3H]-L-deprenyl and [3H]-PK 11195 binding sites in human epileptic hippocampus. Epilepsia 1992; 33: 610–617.

    Article  PubMed  CAS  Google Scholar 

  43. Knoll, J., Magyar, K. Some puzzling effects of monoamine oxydase inhibitors. Adv. Biochem. Psychopharmacol. 1972; 5: 393–408.

    CAS  Google Scholar 

  44. Nakamura, S., Kawamata, T., Akiguchi, I., Kameyama, M., Nakamura, N., Kimura, H. Expression of monoamine oxidase B activity in astrocytes of senile plaques. Acta Neuropathol. 1990; 80: 419–425.

    Article  PubMed  CAS  Google Scholar 

  45. Fowler, J.S., Wolf, A.P., MacGregor, R.R., et al. Mechanistic positron emission tomography studies: demonstration of a deuterium effect in the monoamine oxidase-catalyzed binding of 11C-L-deprenyl in living baboon brain. J. Neurochem. 1988; 51: 1524–1534.

    Article  PubMed  CAS  Google Scholar 

  46. Kumlien, E., Bergström, M., Lilja, A., Andersson, J., Szekeres, V., Westerberg, C-E., Westerberg, G., Antoni, G., Langström, B. Positron emission tomography with 11 Cdeuterium-deprenyl in temporal lobe epilepsy. Epilepsia 1994;In press:.

    Google Scholar 

  47. Sadzot, B., Debets, R.M.C., Maquet, P., Comar, C., Franck, G. PET data interpretation: visual inspection and semi-quantification/quantification. Acta Neurol. Scand. 1994; 89: 175–178.

    Google Scholar 

  48. Sperling, M.R., O’Connor, M.J., Saykin, A.J., Phillips, C.A., Morrel, M.J., Bridgman, P.A., French, J.A., Gonatas, N. A non invasive protocol for anterior temporal lobectomy. Neurology 1992; 42: 416–422.

    PubMed  CAS  Google Scholar 

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Authors
  1. Bernard Sadzot
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  2. René M. C. Debets
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  3. Eric Salmon
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  4. Cornelius W. M. van Veelen
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  5. Guy Delfiore
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  6. Alexander C. van Huffelen
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  7. George Franck
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Editor information

Editors and Affiliations

  1. Department of Nuclear Medicine, Eberhard-Karls-University, Roentgenweg 13, D-72076, Tuebingen, Germany

    Roland B. Bares

  2. INB-CNR, Department of Nuclear Medicine, University of Milan, Scientific Institute H.S., Via Olgettina 60, Raffaele, Milan, I- 20132, Italy

    Giovanni Lucignani

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© 1996 Kluwer Academic Publishers

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Sadzot, B. et al. (1996). Positron Emission Tomography in Partial Epilepsy. In: Bares, R.B., Lucignani, G. (eds) Clinical PET. Developments in Nuclear Medicine, vol 28. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0309-8_11

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  • DOI: https://doi.org/10.1007/978-94-009-0309-8_11

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6624-2

  • Online ISBN: 978-94-009-0309-8

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