Abstract
Positron emitting compounds and positron emission tomography (PET) have opened new windows for the understanding of physiological and pathophysiological mechanisms of myocardial metabolism, receptor physiology and blood flow. This chapter focuses on two areas of clinical relevance where conventional diagnostic techniques may be misleading and a more accurate technique is clearly needed: the exact documentation of the severity of the coronary artery stenosis as a basis for therapeutic planning and the identification of viable myocardium in patients after myocardial infarction.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Porter TR, Sears T, Xie F et al. Intravascular ultrasound study of angiographically mildly diseased coronary arteries. J Am Coll Cardiol 1993; 22: 1858–65.
Davies SW, Winterton SJ, Rothmann MT. Intravascular ultrasound to assess left main stem coronary artery lesion. Br Heart J 1992; 68: 524–6.
Gerber TC, Erbel R, Görge G, Ge J, Rupprecht H-J, Meyer J. Extent of atherosclerosis and remodelling of the left main coronary artery determined by intravascular ultrasound. Am J Cardiol 1994; 73: 666–71.
Sheikh, KH, Harrison JK, Harding MB et al. Detection of angiographically silent coronary atherosclerosis by intracoronary ultrasonography. Am Heart J 1991; 121: 1803–07.
Nissen SE, Gurley JC, Grines CL et al. Intravascular ultrasound of lumen size and wall morphology in normal subjects and patients with coronary artery disease. Circulation 1991; 84: 1087–99.
Tobis JM, Mallery JA, Gessert J. Intravascular ultrasound cross-sectional arterial imaging before and after balloon angioplasty in vitro. Circulation 1989; 80: 87382.
Honye J, Mahon DJ, Jain A et al. Morphological effects of coronary balloon angioplasty in vivo assessed by intravascular ultrasound imaging. Circulation 1992; 85: 1021–25.
Chokshi SK, Hogan J, Desai V et al. Intravascular ultrasound assessment of implanted endovascular stents (abstr). J Am Coll Cardiol 1990; 15: 29A.
Yamagishi M, Miyatake K, Tamai J, Nakatani S, Koyama J, Nissen SE. Intravascular ultrasound detection of atherosclerosis at the site of focal vasospasm in angiographically normal or minimally narrowed coronary segments. J Am Coll Cardiol 1994; 23: 352–57.
Bach RG, Kern MJ, Bell C, Donohue TJ, Aguirre F. Clinical application of coronary flow velocity for stent placement during coronary angioplasty. Am Heart J 1993; 125: 873–77.
Wilson RF, Wyche K, Christensen BV, Laxson DD. Effects of adenosine on human coronary arterial circulation. Circulation 1990; 82: 1595–1606.
Kern MJ, Deligonul U, Aguirre F, Hilton TC. Intravenous adenosine: Continous infusion and low dose bolus administration for determination of coronary vasodilator reserve in patients with and without coronary artery disease. J Am Coll Cardiol 1991; 18: 718–29.
Di Mario C, Strikwerda S, Gil R, de Feyter PL, de Jaegcre P, Serruys PW. Response of conductance and resistance vessels to scalar concentrations of acetycholine: assessment with quantitative angiography and Doppler echography in 29 patients with coronary artery disease Am Heart J 1994; 127: 514–31.
Nakatami S, Yamagishi M, Tamai J, Takai H, Haze K, Miyatake K. Quantitative assessment of coronary artery stenosis by intravascular Doppler catheter technique. Circulation 1992; 85: 1786–1791.
Kenny A, Shapiro LM: Identification of coronary artery stenoses and poststenotic blood flow patterns using a miniture high frequency epicardial transducer, Circulation 1994; 89: 731–39.
Donohue TJ, Kern MJ, Aguirre FV et al. Assessing the hemodynamic significance of coronary artery stenoses: analysis of translesional pressure-flow velocity relations in patients. J Am Coll Cardiol 1993; 22: 449–58
Hamm CW, Reimers J, Ischinger T et al. A randomized study of coronary angioplasty compared with bypass surgery in patients with symptomatic multivessel coronary disease. N Engl J Med 1994: 331: 1037–43.
DeFeyter PJ, Serruys PW, Arnold A et al. Coronary angioplasty of the unstable angina related vessel in patients with multivessel disease. Eur Heart J 1986; 7: 4607
Wohlgelernter D, Cleman M, Highman HA, Zaret BL. Percutaneous transluminal coronary angiography of the Nculprit lcsioni for management of unstable angina pectoris in patients with multivessel coronary artery disease. Am J Cardiol 1986; 58: 460–4.
Shub C, Vliestra RE, Smith HC, Fulton RE, Elveback LR. The unpredictable progression of coronary artery disease: A serial clinical-angiographic analysis. Mayo Clin Proc, 1981; 56: 155–60
Zir LM, Miller SW, Dinsmore RE et al. Interobserver variability in coronary angiography. Circulation 1976: 53: 627–32.
Giroud D, Li JM, Urban P, Meier B, Rutishauser W. Relation of the site of acute myocardial infarction to the most severe coronary arterial stenosis at prior angiography. Am J Cardiol 1992; 69: 729–732.
Little WC, Constantinescu M, Applegate RJ et al. Can coronary angiography predict the site of subsequent myocardial infarction in patients with mild-tomoderate coronary artery disease? Circulation 1988; 78: 1157–66.
Reddy KG, Nair RN, Sheehan HM, Hodgson J Mc B. Evidence that selective endothelial dysfunction may occur in the absence of angiographic or ultrasound atherosclerosis in patients with risk factors for atherosclerosis. J Am Coll Cardiol 1994; 23: 833–43.
Rahimtoola S. The hibernating myocardium. Am Heart J 1989; 117: 211–221.
Barilla F, Gheorghiade M, Kahja F, Goldstein S. Low-dose dobutamine in patients with acute myocardial infarction identifies viable but nor contractile myocardium and predicts the magnitude of improvement in wall motion abnormalities in response to coronary revascularization. Am Heart J 1991; 122: 1522–31.
Baer FM, Voth E, Deutsch HJ, Schneider CA, Schicha H, Sechtem U. Assessment of viable myocardium by dobutamine transesophageal echocardiography and comparison with Fluorine-18 Fluorodeoxglucose Positron Emission Tomography. J Am Coll Cardiol 1994; 24: 343–53.
Tamaki N, Ohtani H, Yonekura Y et al.Significance of fill-in after thallium-201 reinjection following delayed imaging: comparison with regional wall motion and angiographie findings. J Nucl Med 1990; 31: 1617–23
Dilzisian V, Freedman NMT, Bacharach SL, Perrone-Filardi P, Bonow R. Regional thallium uptake in irreversible defects. Circulation 1992; 85: 627–34.
Perrone-Filardi P, Bacharach SL, Dilsizian V, Maurea S, Frank JA, Bonow R. Regional left ventricular wall thickening. Relation to regional uptake of 18Fluorodeoxyglucose and 201 Tl in patients with chronic coronary artery disease and left ventricular dysfunction. Circulation 1992; 86: 1125–37.
Rahimtoola SH. A perspective on the three large multicenter randomized clinical trials of coronary bypass surgery for chronic stable angina. Circulation 1985; 72 (suppl V)V123–35.
Banka VS, Bodenheimer BB, Helfant RH. Determinants of reversible asynergy. Effect of pathologic Q waves, coronary collaterals and anatomic location. Circulation 1974; 50: 714–19.
DiCarli M, Sherman T, Khanna S. Myocardial viability in asysnergic regions subtended by occluded coronary arteries: Relation to the status of collateral flow in patients with chronic artery disease. J Am Coll Cardiol 1994; 23: 860–68.
Popio KA, Gorlin R, Bechtel D, Levine JA. Postextrasystolic potentiation as a predictor of potential myocardial viability: preoperative analyses compared with studies after coronary bypass surgery. Am J Cardiol 1977; 39: 944–53.
Pigott JD, Kouchoukos NT, Oberman A, Cutter GR. Late results of surgical and medical therapy for patients with coronary artery disease and depressed left ventricular function. J Am Coll Cardiol 1985; 5: 1036–45.
Luciani GB, Faggian G, Razzolini, Livi U, Bortolotti U, Mazzucco A. Severe ischemic left ventricular failure: Coronary operation or heart transplantation? Ann Thorac Surg 1993; 55: 719–23.
Ragosta M, Beller GA, Watson DD, Kaul S, Gimple LW. Quantitative planar rest- redistribution 201T1 imaging in detection of myocardial viability and prediction of improvement in left ventricular function after coronary bypass surgery in patients with severely depressed left ventricular function. Circulation 1993; 87: 1630–41.
Dreyfus GD, Duboc D, Blasco A et al. Myocardial viability assessment in ischemic cardiomyopathy: benefits of coronary revascularization. Ann Thorac Surg 1994; 57: 1402–08.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1996 Kluwer Academic Publishers
About this chapter
Cite this chapter
Schneider, C.A., Voth, E., Schicha, H., Sechtem, U. (1996). PET in Cardiology: Clinical Background. In: Bares, R.B., Lucignani, G. (eds) Clinical PET. Developments in Nuclear Medicine, vol 28. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0309-8_1
Download citation
DOI: https://doi.org/10.1007/978-94-009-0309-8_1
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-6624-2
Online ISBN: 978-94-009-0309-8
eBook Packages: Springer Book Archive