Abstract
B-cell non-Hodgkin’s lymphomas are classified histologically into low-grade, intermediate grade and high-grade varieties. The low grade B-NHLs consist of small lymphocytic, follicular small cleaved and follicular mixed categories and comprise approximately 25 to 35% of newly diagnosed NHL. Low grade follicular lymphoma is usually disseminated (stage III-IV) at the time of diagnosis. The disease progresses very slowly without treatment, with a tendency to wax and wane with frequent spontaneous regressions and complete remissions [1]. The initial response to conventional therapies is good, however, after a period of time, relapse occurs and with each relapse the trend is for shorter remissions until the disease becomes refractory to therapy. Disease acceleration is often associated with a worsening prognosis. The median survival time is approximately 8 years regardless of the therapeutic modalities employed. A number of experimental therapies for the treatment of low grade follicular lymphomas including bone marrow transplantation, non-specific immune stimulants, cytokines, monoclonal antibodies, colony stimulating factors and idiotypic vaccines are currently under investigation.
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© 1996 Kluwer Academic Publishers
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Brissinck, J., Zhang, J., Shaw, M., Stevenson, F., Hawkins, R., Russell, S. (1996). Idiotypic vaccination against low grade follicular B cell lymphoma. In: Touraine, J.L., Traeger, J., Bétuel, H., Dubernard, J.M., Revillard, J.P., Dupuy, C. (eds) Cancer in Transplantation: Prevention and Treatment. Transplantation and Clinical Immunology, vol 27. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0175-9_33
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DOI: https://doi.org/10.1007/978-94-009-0175-9_33
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