Abstract
When Epstein–Bar virus (EBV) infects B lymphocytes, it results in either full viral replication and B cell lysis or partial gene expression associated with cell transformation. Cell transformation is associated with B cell activation and continuous proliferation. Under ordinary circumstances, such B cells are suppressed or destroyed by cytotoxic/suppressor cells of the immune system. However, if severe T cell immune deficiency occurs, for instance, after organ transplantation or in patients with primary or acquired immune deficiencies, transformed B cells may proliferate in an uncontrolled fashion [1,2,6,7,9,11,13,15,17,19,20,26,27]. This uncontrolled proliferation may result in tumor formation. Assessment of cell surface immunoglobulin light chain expression or analysis of immunoglobulin gene rearrangements indicate that the tumors are initially polyclonal, but they may progress through an oligoclonal, and finally a monoclonal malignant transformation. This spectrum of EBV-induced proliferation of B lymphocytes is called B cell lymphoproliferative disorder (BLPD).
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Durandy, A., Benkerrou, M., Fischer, A. (1996). Anti-B-cell MAb therapy of transplant-related lymphoproliferative diseases. In: Touraine, J.L., Traeger, J., Bétuel, H., Dubernard, J.M., Revillard, J.P., Dupuy, C. (eds) Cancer in Transplantation: Prevention and Treatment. Transplantation and Clinical Immunology, vol 27. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0175-9_31
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DOI: https://doi.org/10.1007/978-94-009-0175-9_31
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