Abstract
Human T-cell leukemia virus type I (HTLV-I) [1] is a retrovirus unevenly distributed around the World. The main endemic regions are southwestern Japan, intertropical Africa, the Caribbean and South America [2,3]. HTLV-I is the causative agent of Adult T cell leukemia/lymphoma (ATL) [4] and of Tropical spastic paraparesisl HTLV-I associated myelopathy (TSP/HAM) [5]. However, only a small proportion (1 to 5%) of HTLV-I infected individuals will develop an ATL or a TSP/HAM, and the majority of the infected patients remain asymptomatic for their entire life. The biological features of HTLV-I associated syndromes are summarized in Table 1.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Poiesz BJ, Ruscetti FW, Gazdar AF, Bunn PA, Minna JD, Gallo RC. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci USA 1980; 77: 7415–7419.
Müeller N. The epidemiology of HTLV-I infection. Cancer Causes and Control 1991; 2: 37–52.
Kaplan JE, Khabbaz RF. The epidemiology of Human T-lymphotropic virus Types I and II. Medical Virology 1993; 3: 137–148.
Hinuma Y, Nagata K, Hanaoka M et al. Adult T-cell leukaemia: Antigen in an ATL cell line and detection of antibodies to the antigen in human sera. Proc Natl Acad Sci USA 1981; 78: 6476–6480.
Gessain A, Barin F, Vernant JC et al. Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis. Lancet 1985; 2: 407–410.
Bunn PA Jr, Schechter GP, Jaffe E et al. Clinical course of retrovirus-associated adult T cell lymphoma in the United states. N Engl J Med 1983; 309: 257–264.
Shimoyama M. Treatment of patients with adult T-cell leukemia-lymphoma: An overview. Gann Monograph on Cancer Research 1992; 39: 43–56.
Seiki M, Eddy R, Shaws TB, Yoshida M. Non specific integration of the HTLV-I provirus genome into adult T cell leukemia. Nature 1984; 309: 640–642.
Takatsuki F, Yamaguchi K, Hattori T. Adult T-cell leukemia/lymphoma. In: Gallo RC, and Wong-Staal F, editors. Retrovirus Biology and Human Disease, New York: Marcel Decker, 1990; 147–159.
Shimoyama and members of the Lymphoma study group. Diagnostic criteria and clas- sification of clinical subtypes of adult T-cell leukemia-lymphoma. Br J Hem. 1991; 79: 428–437.
Höllsberg P, Hafler D. Pathogenesis of diseases induced by human lymphotropic virus type I infection. N Engl J Med 1993; 328: 1173–1182.
Gessain A, Gout O. Chronic myelopathy associated with human T-lymphotropic virus type I (HTLV-I). Annals of Internal Medicine 1992; 117: 933–946.
Okochi K, Sato H, Hinuma Y. A retrospective study on transmission of adult T-cell leukemia virus type I (HTLV-I) by blood transfusion: seroconversion in recipients. Vox sang 1984; 46: 245–253.
Inaba S, Sato H, Okochi K et al. Prevention of transmission of human T-lymphotropic virus type 1 (HTLV-I) through transfusion, by donor screening with antibody to the virus. One year experience. Transfusion 1989; 29: 7–11.
Sandler S, Fang CT, Williams AE. Human T-cell lymphotropic virus type I and II in transfusion medicine. Transfusion Medicine Reviews 1991; 5: 93–107.
Lairmore MD, Jason JM, Hartley TM, Khabbaz RF, Evatt BL. Absence of human T- cell lymphotropic virus type I coinfection in human immunodeficiency virus-infected hemophilic men. Blood 1989; 74: 2596–2599.
Gessain A, Gazallo L, Yoyo M, Fortier L, Robert Guroff M, De Thé G. Scickle cell anemia patients from Martinique have an increased prevalence of HTLV-I antibodies. Lancet 1984; 2: 1155–1156.
Minamoto G, Gold J, Scheinberg D et al. Infection with human T-cell leukemia virus type I in patients with leukemia. N Engl J Med 1988; 318: 219–222.
Pillonel J, Lemaire JM, Courouce AM. Epidemiologic de l’HTLV-I chez les donneurs de sang domiciliés en France métropolitaine (Juillet 1991-Juin 1993). Med Mai infect 1994; 24: 548–552.
Gout O, Baulac M, Gessain A et al. Rapid development of myelopathy after HTLV-I infection acquired by transfusion during cardiac transplantation. N Engl J Med 1990; 322: 383–388.
Kuroda Y, Takashima H, Yukitake M, Sakemi T. Development of HTLV-I associated myelopathy after blood transfusion in a patient with aplastic anemia and a recipient of a renal transplant. J Neurol Sci 1992; 109: 196–199.
Osame M, Janssen R, Kubota H, et al. Nationwide survey of HTLV-I associated myelopa- thy in Japan: association with blood transfusion. Ann Neurol 1990; 28: 50–56.
Linhares MI, Eizuru Y, de Andrade GP et al. Human T cell leukemia virus type I (HTLV- I) antibodies in healthy populations and renal transplanted patients in the north-east of Brazil. Microbiol Immunol 1994; 38: 475–478.
Perez G, Ortiz-Interian C, Bourgoignie J et al. HIV-1 and HTLV-I infection in renal transplant recipients. J. Acquired Immune Deficiency Syndromes 1990; 3: 35–40.
Loughran TP. Seroprevalence of HTLV-I and HTLV-II in marrow transplant recipients. Bone marrow transplantation 1994; 14: 433–436.
Ljungman P, Lawler M, Asjo B et al. Infection of donor lymphocytes with human T lymphotropic virus type I (HTLV-I) following allogenic bone marrow transplantation for HTLV-I positive adult T-cell leukemia. British J Haematol 1994; 88: 403–405.
Sobue R, Yamauchi T, Miyamura K, et al; Treatment of adult T-cell leukemia with mega- dose cyclophosphamide and total body irradiation followed by allogenic bone marrow transplantation. Bone marrow transplantation 1987; 2: 441–444.
Rio B, Louvet C, Gessain A et al. Adult T cell leukaemia and non malignant adenopathies associated with HTLV-I in patients from the Carribean and Africa. Presse Med 1990; 19: 746–751.
Gill P, Masood R, Cai J et al. Novel antiviral therapy for adult T-cell leukemia secondary to HTLV-I infection. Blood 1992; 80 suppl/1: 74a.
Hermine O, Bouscary D, Gessain A, Turlure P, LeBlond V, Franck N, Buzyn-Veil A, Rio B, Macintyre E, Dreyfus F, Bazarbachi A. Treatment of HTLV-I associated adult T-cell leukemia-lymphoma with a combination of zidovudine and alpha-interferon. N Eng J Med 1995 (In press).
Williams NP, Tsduda H, Yamagushi K et al. Blood transfusion induced opportunistic Adult T-cell leukemia/lymphoma after Hodgkin’s disease. Leukemia and Lymphoma 1991; 5: 435–439.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1996 Kluwer Academic Publishers
About this chapter
Cite this chapter
Bazarbachi, A., Gessain, A. (1996). Human T-cell leukemia virus type I (HTLV-I) and transplantation. In: Touraine, J.L., Traeger, J., Bétuel, H., Dubernard, J.M., Revillard, J.P., Dupuy, C. (eds) Cancer in Transplantation: Prevention and Treatment. Transplantation and Clinical Immunology, vol 27. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0175-9_11
Download citation
DOI: https://doi.org/10.1007/978-94-009-0175-9_11
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-6563-4
Online ISBN: 978-94-009-0175-9
eBook Packages: Springer Book Archive