Abstract
Like many other antibacterials, the origin of the aminoglycoside antibiotics can be traced to the practice of screening culture broths of soil microorganisms in search of antibacterial substances. In 1943, Waksman and colleagues isolated a potent antibacterial compound from a Strepto-myces species (Streptomyces griseus). This substance, streptomycin 1 (Figure 5.1), was structurally unique in containing an aminocyclitol and an aminosugar joined to a ribose unit. Streptomycin captured the attention of the scientific community due to its potency and spectrum of activity; eventually it became a successful drug for the treatment of mycobacterial infections (e.g. tuberculosis). Because of this property, researchers invested efforts to look for other structurally related compounds that were elaborated by other Streptomyces sources. A family of potent antibacterial aminoglycosides followed.
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Dax, S.L. (1997). Aminoglycoside antibiotics. In: Antibacterial Chemotherapeutic Agents. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0097-4_5
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DOI: https://doi.org/10.1007/978-94-009-0097-4_5
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