Skip to main content

Abstract

For ages, humanity has recognized that Nature can provide biologically active concoctions, extracts and substances that are effective in the treatment of a variety of disorders and diseases. Probably no other area of pharmaceutical science has benefited more from this phenomenon than that of infectious disease chemotherapy. The screening of naturally occurring sources in search of novel antibacterial substances became a firmly established practice following the successful saga of the penicillins. By the 1930s and 1940s, the technology had evolved to allow even crude fermentation mixtures to be assayed for antibacterial properties.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Further reading

  • J.J. Hlavka and J.H. Boothe (Eds) (1985)The Tetracyclines Springer-Verlag, Berlin.

    Google Scholar 

  • J.J. Hlavka and J.H. Boothe (1973) ‘The tetracyclines’, inProgress in Drug ResearchVol. 17, E. Jucker (Ed.), Birkhauser Verlag, Basel, pp. 210–240.

    Google Scholar 

  • R.K. Blackwood and A.R. English (1977) ‘Structure-activity relationships in the tetracycline series’, inStructure-Activity Relationships among the Semisynthetic Antibiotics D. Perlman, (Ed.), Academic Press, New York, pp. 397–426.

    Google Scholar 

  • A.I. Laskin (1967) ‘Tetracyclines’, inAntibiotics I, Mechanism of ActionD. Gottlieb andP.D. Shaw (Eds), Springer-Verlag, New York, pp. 331–359.

    Google Scholar 

  • A.I. Laskin and J.A. Last (1971) ‘Tetracyclines’,Antibiotics Chemoth 17, 1.

    CAS  Google Scholar 

  • I. Chopra, R.M. Hawkey and M. Hinton (1992) ‘Tetracyclines, molecular and clinical aspects’,J. Antimicrob. Chemother 29, 245.

    Article  CAS  Google Scholar 

  • T.R. Tritton (1977) ‘Ribosome-tetracycline interactions’.Biochemistry 16, 4133.

    Article  CAS  Google Scholar 

  • G. Hogenauer and F. Turnowsky (1972) ‘The Effects of Streptomycin and Tetracycline on Codon-Anticodon Interactions’,FE BS Lett 26, 185.

    Article  CAS  Google Scholar 

  • J.J. Hlavka, G.A. Ellestad and I. Chopra (1992) ‘Tetracyclines’ (Antibiotics), inKirk-Othmer Encyclopedia of Chemical Technology4th edn., John Wiley, New York, pp. 331–346.

    Google Scholar 

  • L.A. Mitscher (1978)The Chemistry of the Tetracycline AntibioticsMedicinal Research Series, Vol. 9, Marcel Dekker, New York.

    Google Scholar 

  • D.L.J. Clive(1968) ‘Chemistry of tetracyclines’,Quart Rev. (Chem. Soc) 23, 435.

    Google Scholar 

  • F. Johnson (1973) ‘The Total Synthesis of Antibiotics’, inThe Total Synthesis of Natural Products Vol. 1, J. ApSimon (Ed.), John Wiley, New York, pp. 348–364.

    Google Scholar 

  • G.C. Barrett(1963) ‘Synthesis of tetracycline analogs’,J. Pharm. Sei309.

    Google Scholar 

  • H. Muxfeldt, E. Vedejs, G. Haas, G. Hardman, F. Kathawala and J.B. Mooberry (1979) ‘Tetracyclines. 9. Total synthesis of dl-terramycin’,J. Am. Chem. Soc 101, 689–701.

    Google Scholar 

  • S.B. Levy(1984) ‘Resistance to the Tetracyclines’ inAntimicrobial Drug ResistanceL.E. Bryan (Ed.), Academic Press, Orlando, FL,pp. 191–240.

    Google Scholar 

  • S.B. Levy (1992) ‘Active efflux mechanisms for antimicrobial resistance’,Antimicrobial Agents Chemother 36, 695.

    CAS  Google Scholar 

  • I. Chopra and T.G.B. Howe (1978) ‘Bacterial resistance to the tetracyclines’,Microbial. Rev 42, 707.

    CAS  Google Scholar 

  • M.L. Nelson, B.H. Park, J.S. Andrews, V.A. Georgian, R.C. Thomas and S.B. Levy (1993) ‘Inhibition of the tetracycline efflux antiport protein by 13—thio—substituted 5—hydroxy deoxytetracyclines’,J. Med. Chem 36, 370.

    Article  CAS  Google Scholar 

  • A.A. Tymiak, L.A. Mitscher, C. Aklonis, M.S. Bolgar, A.D. Kahle, D.R. Kirsch, J. O’Sullivan, M.A. Porubcan, P. Principe, W.H. Trejo, H.A. Ax, J.S. Wells, N.H. Andersen, P.V. Devasthale, H. Telikepalli, D.V. Velde and J.-Y. Zou (1993) ‘Dactylo-cyclines: Novel tetracycline glycosides active against tetracycline-resistant bacteria’,J. Org. Chem 58, 535.

    Article  CAS  Google Scholar 

  • P.-E. Sum, V.J. Lee, R.T. Testa, J.J. Hlavka, G.A. Ellestad, J.D. Bloom, Y. Gluzman and F.P. Tally (1994) ‘Glycylcyclines. 1. A new generation of potent antibacterial agents through modification of 9-aminotetracyclines’,J. Med. Chem37, 184.

    Article  CAS  Google Scholar 

  • R.T. Testa, J.J. Hlavka, J.D. Bloom, G.A. Ellestad, Y. Gluzman, N.V. Jacobus, V.J. Lee, P.J. Petersen, P.-E. Sum, F.P. Tally and W.J. Weiss (1993) ‘Glycylcyclines…’, 33rd Interscience Conference on Antimicrobial Agents and Chemotherapy(sponsored by the American Society for Microbiology), New Orleans, LA, October, 17–20, poster abstracts 431, 432, 433, 442, 443.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 1997 Chapman & Hall

About this chapter

Cite this chapter

Dax, S.L. (1997). Tetracycline Antibiotics. In: Antibacterial Chemotherapeutic Agents. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0097-4_4

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-0097-4_4

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6531-3

  • Online ISBN: 978-94-009-0097-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics