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Raman Spectroscopy during Catheterization: A Means of Viewing Plaque Composition

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Book cover Vascular Medicine

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 197))

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Abstract

The progression and regression of atherosclerotic plaques appear to be related to the amount and type of lipids that accumulate in the intima of arteries.1–3 Recent studies have shown that plaque composition, rather than size or volume, determines whether an arterial narrowing will rupture and cause an acceleration of clinical symptoms.4,5 Clearly, an instrument is needed that can determine in situ the chemical composition of atherosclerotic lesions objectively and accurately. Raman spectroscopy is a powerful technique, capable of providing detailed, quantitative information about the chemical composition of arterial wall non-destructively. Such an instrument would be useful to clinicians and researchers in many applications, such as predicting plaque rupture and selecting proper therapeutic interventions. In this chapter, a review is given of the basic principles and potential applications of Raman spectroscopy.

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Authors
  1. Tjeerd J. Römer
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  2. James F. Brennan III
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Editor information

Editors and Affiliations

  1. Department of Cardiology, Leiden University Medical Centre, Leiden, The Netherlands

    Ernst E. van der Wall , Volkert Manger Cats  & Jan Baan ,  & 

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© 1997 Kluwer Academic Publishers

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Römer, T.J., Brennan, J.F. (1997). Raman Spectroscopy during Catheterization: A Means of Viewing Plaque Composition. In: van der Wall, E.E., Cats, V.M., Baan, J. (eds) Vascular Medicine. Developments in Cardiovascular Medicine, vol 197. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0037-0_11

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  • DOI: https://doi.org/10.1007/978-94-009-0037-0_11

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6505-4

  • Online ISBN: 978-94-009-0037-0

  • eBook Packages: Springer Book Archive

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