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Lipid Hydroperoxide-Derived Modification of Proteins in Gastrointestinal Tract

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Lipid Hydroperoxide-Derived Modification of Biomolecules

Part of the book series: Subcellular Biochemistry ((SCBI,volume 77))

Abstract

Role of lipid peroxidation in the pathogenesis of gastrointestinal diseases has been evaluated by measuring the tissue levels of lipid peroxides as thiobarbituric acid-reactive substances in the animal models as well as human. Recently, N ε-(hexanoyl)lysine (HEL) and 4-hydroxy-2-nonenal (HNE) are recognized as reliable and sensitive biomarkers for the early phase and the late phase of lipid peroxidation, respectively. The presence of HNE- and HEL-modified proteins has been demonstrated in in vivo models of several gastrointestinal diseases. In the present review, we introduced HNE-modification of TRPV1 channel in esophageal epithelial cells, HEL-modification of tropomyosin 1 (TMP1) in gastric cancer cells, and HEL-modification of gastrokine 1 in the healing of gastric ulcer.

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Authors and Affiliations

  1. Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, 465 Kajiicho, Kamigyo-ku, Kyoto, 602-8566, Japan

    Yuji Naito, Tomohisa Takagi, Osamu Handa & Toshikazu Yoshikawa

Authors
  1. Yuji Naito
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  2. Tomohisa Takagi
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  3. Osamu Handa
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  4. Toshikazu Yoshikawa
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Correspondence to Yuji Naito .

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Editors and Affiliations

  1. School of Human Science & Environment, University of Hyogo, Himeji, Hyogo, Japan

    Yoji Kato

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Naito, Y., Takagi, T., Handa, O., Yoshikawa, T. (2014). Lipid Hydroperoxide-Derived Modification of Proteins in Gastrointestinal Tract. In: Kato, Y. (eds) Lipid Hydroperoxide-Derived Modification of Biomolecules. Subcellular Biochemistry, vol 77. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7920-4_12

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