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Biologically Relevant Molecules Studied in Low Temperature Inert Matrices

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Book cover Optical Spectroscopy and Computational Methods in Biology and Medicine

Part of the book series: Challenges and Advances in Computational Chemistry and Physics ((COCH,volume 14))

Abstract

Matrix isolation is a technique where gaseous atoms and molecules are trapped in an environment of solidified inert gases at temperatures close to absolute zero. The method was originally used to study free radicals and other short-lived chemical reaction intermediates, but receives nowadays many other uses, including its application to the study of molecules of biological importance. Without surprise, the method has been progressively catching the interest of biochemists and molecular biologists, and has been applied to many molecules with pharmaceutical or medical use. In this Chapter, we describe the use of matrix isolation infrared spectroscopy to investigate molecules of biological interest. The fundamentals of the technique are briefly presented, and examples of its application to the study of different phenomena in a series of selected molecules of biological relevance are provided.

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Acknowledgements

The authors thank all their colleagues involved in the studies described in more detail in this Chapter. Finantial support from Fundação para a Ciência e a Tecnologia (FCT – Portugal) is acknowledged.

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Authors and Affiliations

  1. Department of Chemistry, University of Coimbra, 3004-535, Coimbra, Portugal

    Rui Fausto & Nihal Kuş

  2. Department of Physics, Anadolu University, 26470, Eskişehir, Turkey

    Nihal Kuş

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  1. Rui Fausto
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  2. Nihal Kuş
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Correspondence to Rui Fausto .

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Editors and Affiliations

  1. Faculty of Chemistry, Jagiellonian University, Ingardena 3, Krakow, Poland

    Malgorzata Baranska

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Fausto, R., Kuş, N. (2014). Biologically Relevant Molecules Studied in Low Temperature Inert Matrices. In: Baranska, M. (eds) Optical Spectroscopy and Computational Methods in Biology and Medicine. Challenges and Advances in Computational Chemistry and Physics, vol 14. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7832-0_7

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