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Optical Spectroscopy and Computational Methods in Biology and Medicine pp 505–535Cite as

Vibrational Microspectroscopy for Analysis of Atherosclerotic Arteries

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Part of the book series: Challenges and Advances in Computational Chemistry and Physics ((COCH,volume 14))

Abstract

This Chapter describes the fundamental principles of atherosclerotic plaque formation along with features detectable by histology. The main focus is on reviewing the use of Raman and IR spectroscopy in the study of atherosclerotic arteries. The analysis of the experimental results is possible only with the application of mathematical and statistical tools of analysis, i.e. chemometrics, which are also described. This chapter proves that chemometrics allows us to create a link between IR and Raman spectroscopy and their application in chemistry.

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Acknowledgements

This study was supported by European Union from the resources of the European Regional Development Fund under the Innovative Economy Programme (grant coordinated by JCET-UJ, No POIG.01.01.02-00-069/09). The tissues for histological and vibrational microscopy examples of atherosclerotic plaque analysis presented in this chapter were taken from ApoE/LDLR–/– mice [128].

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Authors and Affiliations

  1. Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, Bobrzynskiego 14, 30-348, Krakow, Poland

    K.M. Marzec, T.P. Wróbel, A. Fedorowicz, Ł. Mateuszuk, E. Maślak, A. Jasztal & S. Chlopicki

  2. Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060, Krakow, Poland

    T.P. Wróbel

  3. Department of Experimental Pharmacology, Chair of Pharmacology, Jagiellonian University, Medical College, Grzegorzecka 16, 31-531, Krakow, Poland

    S. Chlopicki

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Correspondence to K.M. Marzec .

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    Malgorzata Baranska

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Marzec, K. et al. (2014). Vibrational Microspectroscopy for Analysis of Atherosclerotic Arteries. In: Baranska, M. (eds) Optical Spectroscopy and Computational Methods in Biology and Medicine. Challenges and Advances in Computational Chemistry and Physics, vol 14. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7832-0_17

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