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Optical Spectroscopy and Computational Methods in Biology and Medicine pp 475–504Cite as

Fourier Transform Infrared (Ft-Ir) Spectroscopic Imaging for Solid Tumor Histopathology

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Part of the book series: Challenges and Advances in Computational Chemistry and Physics ((COCH,volume 14))

Abstract

Fourier transform infrared (FT-IR) spectroscopic imaging has shown great promise in becoming a powerful tool in cytology and histopathology. Applications for cancer diagnoses in solid tumors are especially attractive as samples are spatially complex and involve myriad molecular changes whereas there are many shortcomings in current clinical practice that can be addressed. Here we review the current state of the art in applying FT-IR imaging for analyzing solid tumors. We focus on instrumentation that is relatively new, emerging fundamental understanding gained by new theoretical advances, data analysis and selected, illustrative applications in cancer histopathology.

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Notes

  1. 1.

    Many issues are summarized in [6].

  2. 2.

    Note that some texts refer to this practice as “False Color”. This term is misleading as all colors are true. “Color-coded” images or “Representative color” images are probably better monikers.

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Authors and Affiliations

  1. Biophysics program, University of Illinois Urbana-Champaign, 61801, Urbana, IL, USA

    Sreeradha Biswas

  2. Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, 61801, Urbana, IL, USA

    Michael J. Walsh

  3. Departments of Bioengineering, Mechanical Science and Engineering, Electrical and Computer Engineering, Chemical and Biomolecular Engineering and Chemistry, University of Illinois Urbana-Champaign, 61801, Urbana, IL, USA

    Rohit Bhargava

Authors
  1. Sreeradha Biswas
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  2. Michael J. Walsh
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  3. Rohit Bhargava
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Correspondence to Rohit Bhargava .

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Editors and Affiliations

  1. Faculty of Chemistry, Jagiellonian University, Ingardena 3, Krakow, Poland

    Malgorzata Baranska

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Biswas, S., Walsh, M., Bhargava, R. (2014). Fourier Transform Infrared (Ft-Ir) Spectroscopic Imaging for Solid Tumor Histopathology. In: Baranska, M. (eds) Optical Spectroscopy and Computational Methods in Biology and Medicine. Challenges and Advances in Computational Chemistry and Physics, vol 14. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7832-0_16

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