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Regulation of the Novel Senescence Pathway by SKP2 E3 Ligase

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Tumor Dormancy, Quiescence, and Senescence, Volume 2

Part of the book series: Tumor Dormancy and Cellular Quiescence and Senescence ((DOQU,volume 2))

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Abstract

Cellular senescence, a stress response triggered by multiple stimuli, results in a form of irreversible cell cycle arrest that can serve as a critical barrier for cancer development. Various studies have demonstrated the critical role of ARF/p53 pathways in the induction of cellular senescence by activation of oncogenic pathways through overexpression of oncogenes, such as Ras, or by inactivation of tumor suppressor genes, such as PTEN. Recent studies also uncover novel ARF/p53-independent cellular senescence pathways in restricting tumorigenesis. Given that ARF/p53 pathways play an essential role in tumor suppression and are often inactivated in human cancers through deficiency or mutations of ARF or p53, better understanding of these pathways governing the induction of senescence in human cancer will pave the ways for developing effective pro-senescence therapies. Thus, it’s important to screen current available drugs that stabilize p53 expression for the ability to target possibility that these Arf-p53 dependent pathways or by developing novel inhibitors to target the Arf-p53 independent pathways.

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Acknowledgements

This work is supported in part by National Institutes of Health grants (R01CA136787-01A2 and R01CA149321-01), MD Anderson Trust Scholar Fund, a grant from Cancer Prevention Research Institute of Texas and by a New Investigator Award from the Department of Defense (PC081292) to H.K. Lin.

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Authors and Affiliations

  1. Department of Genomic Medicine, MD Anderson Cancer Center, University of Texas, Houston, TX, USA

    Guocan Wang

  2. Department of Molecular and Cellular Oncology, MD Anderson Cancer Center, University of Texas, Houston, TX, USA

    Yuan Gao & Li Chen

  3. Department of Molecular and Cellular Oncology, MD Anderson Cancer Center, The University of Texas, Houston, TX, 77030, USA

    Ying-Jan Wang & Hui-Kuan Lin

  4. Department of Environmental and Occupational Health, National Cheng Kung University, Medical College, Tainan, Taiwan

    Ying-Jan Wang

  5. Graduate Institute of Basic Medical Science, China Medical University, Taichung, 404, Taiwan

    Hui-Kuan Lin

  6. Department of Biotechnology, Asia University, Taichung, 404, Taiwan

    Hui-Kuan Lin

Authors
  1. Guocan Wang
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  2. Yuan Gao
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  3. Li Chen
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  4. Ying-Jan Wang
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  5. Hui-Kuan Lin
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Corresponding author

Correspondence to Hui-Kuan Lin .

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Editors and Affiliations

  1. Department of Biological Sciences, Kean University, Room 213, Library Building, Union, New Jersey, USA

    M.A. Hayat

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Wang, G., Gao, Y., Chen, L., Wang, YJ., Lin, HK. (2014). Regulation of the Novel Senescence Pathway by SKP2 E3 Ligase. In: Hayat, M. (eds) Tumor Dormancy, Quiescence, and Senescence, Volume 2. Tumor Dormancy and Cellular Quiescence and Senescence, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7726-2_4

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