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Quiescent CD4+ T Cells Inhibit Multiple Stages of HIV Infection

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Tumor Dormancy, Quiescence, and Senescence, Volume 2

Part of the book series: Tumor Dormancy and Cellular Quiescence and Senescence ((DOQU,volume 2))

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Abstract

Elucidating the block of quiescent CD4+ T cells to HIV infection has been an intensely debated issue. Early studies suggested that the virus could not infect this T cell subset; latter studies demonstrated that these cells could inefficiently support HIV infection. The kinetics of infection in quiescent cells was delayed and multiple stages of the viral life cycle were marred by inefficiencies. A number of restriction factors as well as cellular protein have been implicated in the potential block. However, to this date the mechanisms of HIV infection in quiescent cells are still unclear. Further understanding will open the way for better therapeutic approaches and much improved gene therapy protocols using HIV-based vectors.

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Acknowledgements

This work was supported by in part by NIH/NIAID AI 070010-06A1, NIH Martin Delaney Collaboratory(to J.A.Z.), UCLA Center for AIDS Research NIH/National Institute of Allergy and Infectious Diseases Grant AI028697, NIH/NIDA R21 DA031036-01A1 (D.N.V.).

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Authors and Affiliations

  1. Division of Hematology-Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095, USA

    Jerome A. Zack

  2. UCLA AIDS Institute, Los Angeles, CA, USA

    Jerome A. Zack

  3. Division of Hematology-Oncology, Department of Medicine, David Geffen School of Medicine at UCLA, 615 Charles E. Young Drive South, BSRB 173, Mailcode: 736322, Los Angeles, CA, 90095, USA

    Dimitrios N. Vatakis

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  1. Jerome A. Zack
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  2. Dimitrios N. Vatakis
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Correspondence to Dimitrios N. Vatakis .

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  1. Department of Biological Sciences, Kean University, Room 213, Library Building, Union, New Jersey, USA

    M.A. Hayat

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Zack, J.A., Vatakis, D.N. (2014). Quiescent CD4+ T Cells Inhibit Multiple Stages of HIV Infection. In: Hayat, M. (eds) Tumor Dormancy, Quiescence, and Senescence, Volume 2. Tumor Dormancy and Cellular Quiescence and Senescence, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7726-2_24

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