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Premalignancy and Cellular Senescence

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Tumor Dormancy, Quiescence, and Senescence, Volume 2

Part of the book series: Tumor Dormancy and Cellular Quiescence and Senescence ((DOQU,volume 2))

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Abstract

Tumorigenesis is s a multistage process characterized by multiple genetic and molecular insults. The progression from premalignancy to malignancy requires bypass of tumor suppressor mechanisms such as apoptosis and cellular senescence. While apoptosis has long been considered a tumor suppressor mechanism, senescence has recently been verified to be a major impediment for cancer progression, especially in premalignant lesions. In this chapter, we discuss the characteristics of premalignant in comparison to malignant tumors, the role of senescence in impeding the transition, and the mechanisms by which tumor cells are able to escape cellular senescence during cancer progression. This chapter also summarizes what is currently known about the process of cellular senescence in tumor suppression, including the inducers, markers, and molecular pathways involved. Finally, we discuss implications of induction of cellular senescence as a therapeutic strategy in clinical management of premalignant and malignant tumors.

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Authors and Affiliations

  1. Children’s Cancer Center of Lebanon, American University of Beirut, Beirut, Lebanon

    Hussein A. Abbas & Raya Saab

Authors
  1. Hussein A. Abbas
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  2. Raya Saab
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Correspondence to Raya Saab .

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Editors and Affiliations

  1. Department of Biological Sciences, Kean University, Room 213, Library Building, Union, New Jersey, USA

    M.A. Hayat

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Abbas, H.A., Saab, R. (2014). Premalignancy and Cellular Senescence. In: Hayat, M. (eds) Tumor Dormancy, Quiescence, and Senescence, Volume 2. Tumor Dormancy and Cellular Quiescence and Senescence, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7726-2_19

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