Abstract
Intraoperative ultrasonography (iUS) has been used in neurosurgery since the early 1980s. The intraoperative anatomy and pathology can be displayed in real-time in B-mode imaging whereas color Doppler adds flow information. Recent advances in imaging techniques such as improvements in image quality, navigating the ultrasound (US) probe and the introduction of three-dimensional (3D) US have increased the utility of iUS for neurosurgery. Numerous reports have shown that iUS helps in tumor visualization, location and delineation as well as planning the optimal approach to subcortical or deep-seated lesions. Intraoperative color Doppler can add vascular information, thus facilitating approach planning. Moreover, iUS is a tool that is fast and easy to apply when controlling the extent of tumor resection, as it is highly sensitive in experienced hands to detect tumor remnants. However, the examiner has to be aware, that tumor remnants might be overestimated by iUS during surgery and that a slim hyperechoic rim around the resection cavity might mask residual tumor. Intraoperative US can be an alternative in the guidance of biopsies and has shown to be helpful in spinal tumor cases. iUS is a simple way of intraoperative image update, providing real-time information in different stages of tumor resection.
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References
Benediktsson H, Andersson T, Sjolander U, Hartman M, Lindgren PG (1992) Ultrasound guided needle biopsy of brain tumors using an automatic sampling instrument. Acta Radiol 33:512–517
Chacko AG, Kumar NK, Chacko G, Athyal R, Rajshekhar V (2003) Intraoperative ultrasound in determining the extent of resection of parenchymal brain tumours–a comparative study with computed tomography and histopathology. Acta Neurochir 145:743–748 (Wien)
Coenen VA, Krings T, Weidemann J, Hans FJ, Reinacher P, Gilsbach JM, Rohde V (2005) Sequential visualization of brain and fiber tract deformation during intracranial surgery with three-dimensional ultrasound: an approach to evaluate the effect of brain shift. Neurosurgery 56:133–141
Di Lorenzo N, Esposito V, Lunardi P, Delfini R, Fortuna A, Cantore G (1991) A comparison of computerized tomography-guided stereotactic and ultrasound-guided techniques for brain biopsy. J Neurosurg 75:763–765
Enchev Y, Bozinov O, Miller D, Tirakotai W, Heinze S, Benes L, Bertalanffy H, Sure U (2006) Image-guided ultrasonography for recurrent cystic gliomas. Acta Neurochir 148:1053–1063 (Wien)
Engelhardt M, Hansen C, Eyding J, Wilkening W, Brenke C, Krogias C, Scholz M, Harders A, Ermert H, Schmieder K (2007) Feasibility of contrast-enhanced sonography during resection of cerebral tumours: initial results of a prospective study. Ultrasound Med Biol 33:571–575
Enzmann DR, Britt RH, Lyons BE, Buxton JL, Wilson DA (1981) Natural history of experimental intracerebral hemorrhage: sonography, computed tomography and neuropathology. AJNR Am J Neuroradiol 2:517–526
Gerganov VM, Samii A, Akbarian A, Stieglitz L, Samii M, Fahlbusch R (2009) Reliability of intraoperative high-resolution 2D ultrasound as an alternative to high-field strength MR imaging for tumor resection control: a prospective comparative study. J Neurosurg 111:512–519
Gerganov VM, Samii A, Giordano M, Samii M, Fahlbusch R (2011) Two-dimensional high-end ultrasound imaging compared to intraoperative MRI during resection of low-grade gliomas. J Clin Neurosci 18:669–673
Gronningsaeter A, Kleven A, Ommedal S, Aarseth TE, Lie T, Lindseth F, Lango T, Unsgard G (2000) SonoWand, an ultrasound-based neuronavigation system. Neurosurgery 47:1373–1379
Hammoud MA, Ligon BL, elSouki R, Shi WM, Schomer DF, Sawaya R (1996) Use of intraoperative ultrasound for localizing tumors and determining the extent of resection: a comparative study with magnetic resonance imaging. J Neurosurg 84:737–741
He W, Jiang XQ, Wang S, Zhang MZ, Zhao JZ, Liu HZ, Ma J, Xiang DY, Wang LS (2008) Intraoperative contrast-enhanced ultrasound for brain tumors. Clin Imaging 32:419–424
Kanno H, Ozawa Y, Sakata K, Sato H, Tanabe Y, Shimizu N, Yamamoto I (2005) Intraoperative power Doppler ultrasonography with a contrast-enhancing agent for intracranial tumors. J Neurosurg 102:295–301
Koivukangas J, Louhisalmi Y, Alakuijala J, Oikarinen J (1993) Ultrasound-controlled neuronavigator-guided brain surgery. J Neurosurg 79:36–42
LeRoux PD, Berger MS, Wang K, Mack LA, Ojemann GA (1992) Low grade gliomas: comparison of intraoperative ultrasound characteristics with preoperative imaging studies. J Neurooncol 13:189–198
LeRoux PD, Winter TC, Berger MS, Mack LA, Wang K, Elliott JP (1994) A comparison between preoperative magnetic resonance and intraoperative ultrasound tumor volumes and margins. J Clin Ultrasound 22:29–36
Lindner D, Trantakis C, Renner C, Arnold S, Schmitgen A, Schneider J, Meixensberger J (2006) Application of intraoperative 3D ultrasound during navigated tumor resection. Minim Invasive Neurosurg 49:197–202
Lunardi P, Acqui M, Maleci A, Di Lorenzo N, Fortuna A (1993) Ultrasound-guided brain biopsy: a personal experience with emphasis on its indication. Surg Neurol 39:148–151
Miller D, Heinze S, Tirakotai W, Bozinov O, Surucu O, Benes L, Bertalanffy H, Sure U (2007) Is the image guidance of ultrasonography beneficial for neurosurgical routine? Surg Neurol 67:579–587
Miller D, Benes L, Sure U (2011) Stand-alone 3D-ultrasound navigation after failure of conventional image guidance for deep-seated lesions. Neurosurg Rev 34:381–387; discussion 387–388
Miller D, Lippert C, Vollmer F, Bozinov O, Benes L, Schulte DM, Sure U (2012) Comparison of different reconstruction algorithms for three-dimensional ultrasound imaging in a neurosurgical setting. Int J Med Robot 8(3):348–359
Moiyadi A, Shetty P (2011) Objective assessment of utility of intraoperative ultrasound in resection of central nervous system tumors: a cost-effective tool for intraoperative navigation in neurosurgery. J Neurosci Rural Pract 2:4–11
Otsuki H, Nakatani S, Yamasaki M, Kinoshita A, Iwamoto F, Kagawa N (2001) Intraoperative ultrasound arteriography with the “Coded Harmonic Angio” technique. Report of three cases. J Neurosurg 94:992–995
Peredo-Harvey I, Lilja A, Mathiesen T (2012) Post-craniotomy neuronavigation based purely on intraoperative ultrasound imaging without preoperative neuronavigational planning. Neurosurg Rev 35:263–268; discussion 268
Regelsberger J, Fritzsche E, Langer N, Westphal M (2005) Intraoperative sonography of intra- and extramedullary tumors. Ultrasound Med Biol 31:593–598
Reinertsen I, Lindseth F, Unsgaard G, Collins DL (2007) Clinical validation of vessel-based registration for correction of brain-shift. Med Image Anal 11:673–684
Rohde V, Coenen VA (2011) Intraoperative 3-dimensional ultrasound for resection control during brain tumour removal: preliminary results of a prospective randomized study. Acta Neurochir Suppl 109:187–190
Rubin JM, Mirfakhraee M, Duda EE, Dohrmann GJ, Brown F (1980) Intraoperative ultrasound examination of the brain. Radiology 137:831–832
Rygh OM, Nagelhus Hernes TA, Lindseth F, Selbekk T, Brostrup MT, Unsgaard G (2006) Intraoperative navigated 3-dimensional ultrasound angiography in tumor surgery. Surg Neurol 66:581–592
Rygh OM, Selbekk T, Torp SH, Lydersen S, Hernes TA, Unsgaard G (2008) Comparison of navigated 3D ultrasound findings with histopathology in subsequent phases of glioblastoma resection. Acta Neurochir 150:1033–1041, (Wien) discussion 1042
Strowitzki M, Moringlane JR, Steudel W (2000) Ultrasound-based navigation during intracranial burr hole procedures: experience in a series of 100 cases. Surg Neurol 54:134–144
Sure U, Benes L, Bozinov O, Woydt M, Tirakotai W, Bertalanffy H (2005) Intraoperative landmarking of vascular anatomy by integration of duplex and Doppler ultrasonography in image-guided surgery. Technical note. Surg Neurol 63:133–141
Tirakotai W, Miller D, Heinze S, Benes L, Bertalanffy H, Sure U (2006) A novel platform for image-guided ultrasound. Neurosurgery 58:710–718
Trantakis C, Meixensberger J, Lindner D, Strauss G, Grunst G, Schmidtgen A, Arnold S (2002) Iterative neuronavigation using 3D ultrasound. A feasibility study. Neurol Res 24:666–670
Tronnier V, Bonsanto MM, Staubert A, Knauth M, Kunze S, Wirtz CR (2001) Comparison of intraoperative MR imaging and 3D-navigated ultrasonography in the detection and resection control of lesions. Neurosurg Focus 10:1–5
Tsutsumi Y, Andoh Y, Sakaguchi J (1989) A new ultrasound-guided brain biopsy technique through a burr hole. Technical note. Acta Neurochir 96:72–75 (Wien)
Unsgaard G, Ommedal S, Muller T, Gronningsaeter A, Nagelhus Hernes TA (2002) Neuronavigation by intraoperative three-dimensional ultrasound: initial experience during brain tumor resection. Neurosurgery 50:804–812
Unsgaard G, Selbekk T, Brostrup MT, Ommedal S, Torp SH, Myhr G, Bang J, Nagelhus Hernes TA (2005) Ability of navigated 3D ultrasound to delineate gliomas and metastases–comparison of image interpretations with histopathology. Acta Neurochir 147:1259–1269 (Wien)
van Velthoven V, Auer LM (1990) Practical application of intraoperative ultrasound imaging. Acta Neurochir 105:5–13 (Wien)
Woydt M, Krone A, Becker G, Schmidt K, Roggendorf W, Roosen K (1996) Correlation of intra-operative ultrasound with histopathologic findings after tumour resection in supratentorial gliomas. A method to improve gross total tumour resection. Acta Neurochir 138:1391–1398 (Wien)
Zhou H, Miller D, Schulte DM, Benes L, Rosenow F, Bertalanffy H, Sure U (2009) Transsulcal approach supported by navigation-guided neurophysiological monitoring for resection of paracentral cavernomas. Clin Neurol Neurosurg 111:69–78
Zhou H, Miller D, Schulte DM, Benes L, Bozinov O, Sure U, Bertalanffy H (2011) Intraoperative ultrasound assistance in treatment of intradural spinal tumours. Clin Neurol Neurosurg 113:531–537
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Miller, D. (2014). Intraoperative Ultrasonography in Tumor Surgery. In: Hayat, M. (eds) Tumors of the Central Nervous System, Volume 13. Tumors of the Central Nervous System, vol 13. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7602-9_13
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DOI: https://doi.org/10.1007/978-94-007-7602-9_13
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