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Reirradiation

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Bone Metastases

Part of the book series: Cancer Metastasis - Biology and Treatment ((CMBT,volume 21))

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Abstract

Radiotherapy for metastatic bone pain and metastatic spinal cord compression has a high rate of success but in a proportion of patients there will be recurrence of symptoms requiring retreatment. This can be undertaken safely after initial use of external beam and radioisotope therapy for metastatic bone pain with similar rates of success to those seen after primary treatment. Retreatment for metastatic cord compression must respect spinal cord tolerance doses and stereotactic techniques may have an important role.

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References

  1. Huddart RA, Rajan B, Law M et al (1997) Spinal cord compression in prostate cancer: treatment outcome and prognostic factors. Radiother Oncol 44:229–236

    Article  PubMed  CAS  Google Scholar 

  2. Chow E, Zeng L, Salvo N et al (2012) Update on the systematic review of palliative radiotherapy trials for bone. Clin Oncol 24:112–124

    Article  CAS  Google Scholar 

  3. Bone Pain Trial Working Party (1999) 8 Gy single fraction radiotherapy for the treatment of metastatic skeletal pain: randomised comparison with a multifraction schedule over 12 months of patient follow-up. Radiother Oncol 52:111–121

    Article  Google Scholar 

  4. Van der Linden Y, Lok JJ, Steinland E et al (2004) Single fraction radiotherapy is efficacious: a further analysis of the Dutch bone pain metastasis study controlling for the influence of retreatment. Int J Radiat Oncol Biol Phys 59:528–537

    Article  PubMed  Google Scholar 

  5. Huisman M, van den Bosch MAAJ, Wijlemans JW et al (2012) Effectiveness of reirradiation for painful bone metastases: a systematic review and meta-analysis. Int J Radiat Oncol Biol Phys 84:8–14

    Article  PubMed  Google Scholar 

  6. Finlay IG, Mason MD, Shelley M (2005) Radioisotopes for the palliation of metastatic bone cancer: a systematic review. Lancet Oncol 6:392–400

    Article  PubMed  CAS  Google Scholar 

  7. Laing AH, Ackery DM, Bayly RJ et al (1991) Strontium-89 chloride for pain palliation in prostatic skeletal malignancy. Br J Radiol 64:816–822

    Article  PubMed  CAS  Google Scholar 

  8. McEwan RJ (2000) Uses of radioisotopes for the palliation of bone metastases. Sem Radiat Oncol 10:103–104

    Article  CAS  Google Scholar 

  9. Robinson RG, Preston DF, Schiefelbein M et al (1995) Strontium 89 therapy for the palliation of pain due to osseous metastases. JAMA 274:420–424

    Article  PubMed  CAS  Google Scholar 

  10. Rades D, Stalpers LJS, Veninga T et al (2005) Spinal reirradiation after short course RT for metastatic spinal cord compression. Int J Radiat Oncol Biol Phys 63:872–875

    Article  PubMed  Google Scholar 

  11. Schiff D, Shaw EG, Cascino TL (1995) Outcome after spinal reirradiation for malignant epidural spinal cord compression. Ann Neurol 37:583–589

    Article  PubMed  CAS  Google Scholar 

  12. Masucci GL, Lu E, Ma L et al (2011) Stereotactic body radiotherapy is an effective treatment in reirradiating spinal metastases: current status and practical considerations for safe practice. Expert Rev Anticancer Ther 11(12):1923–1933

    Article  PubMed  Google Scholar 

  13. Sahgal A, Ma L, Weinberg V et al (2012) Reirradiation human spinal cord tolerance for stereotactic body radiotherapy. Int J Radiat Oncol Biol Phys 82:107–116

    Article  PubMed  Google Scholar 

  14. Neider C, Grosu AL, Andratschke NH et al (2005) Molls M Proposal of human spinal cord reiradiation dose based on collection of data from 40 patients. Int J Radiat Oncol Biol Phys 61:851–855

    Article  Google Scholar 

  15. Kirkpatrick JP, van der Kogel B, Schulthiess TE (2010) Radiation dose-volume effects in the spinal cord. Int J Radiat Oncol Biol Phys 76:S42–S49, Supplement

    Article  PubMed  Google Scholar 

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Correspondence to Peter Hoskin .

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© 2014 Springer Science+Business Media Dordrecht

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Hoskin, P. (2014). Reirradiation. In: Vassiliou, V., Chow, E., Kardamakis, D. (eds) Bone Metastases. Cancer Metastasis - Biology and Treatment, vol 21. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7569-5_18

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