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G Protein-Coupled Receptors - Modeling and Simulation pp 15–33Cite as

Modeling of G Protein-Coupled Receptors Using Crystal Structures: From Monomers to Signaling Complexes

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 796))

Abstract

G protein–coupled receptors constitute a large and functionally diverse family of transmembrane proteins. They are fundamental in the transfer of extracellular stimuli to intracellular signaling pathways and are among the most targeted proteins in drug discovery. Recent advances in crystallization methods have permitted to resolve the molecular structure of several members of the family. This chapter focuses on the impact of these structures in the use of homology modeling techniques for building three-dimensional models of homologous G protein–coupled receptors, higher order oligomers, and their complexes with ligands and signaling proteins.

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Authors and Affiliations

  1. Laboratori de Medicina Computacional, Unitat de Bioestadística, Facultat de Medicina, Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain

    Angel Gonzalez, Arnau Cordomí, Minos Matsoukas, Julian Zachmann & Leonardo Pardo

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  1. Angel Gonzalez
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  2. Arnau Cordomí
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  3. Minos Matsoukas
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  4. Julian Zachmann
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  5. Leonardo Pardo
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Correspondence to Leonardo Pardo .

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  1. Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, New York,, New York, USA

    Marta Filizola

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Gonzalez, A., Cordomí, A., Matsoukas, M., Zachmann, J., Pardo, L. (2014). Modeling of G Protein-Coupled Receptors Using Crystal Structures: From Monomers to Signaling Complexes. In: Filizola, M. (eds) G Protein-Coupled Receptors - Modeling and Simulation. Advances in Experimental Medicine and Biology, vol 796. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7423-0_2

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