Skip to main content
SpringerLink
Log in
Book cover

Edible Medicinal And Non-Medicinal Plants pp 656–680Cite as

Lonicera japonica

  • Chapter
  • First Online:

  • 4846 Accesses

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   299.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   379.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   379.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Selected References

  • Anonymous (2006) Japanese honeysuckle. Lonicera japonica, Natural resources and water facts - pest series, PP 83. The State of Queensland (Department of Natural Resources and Water), Brisbane

    Google Scholar 

  • Blood K (2001) Environmental weeds: a field guide for SE Australia. C.H. Jerram and Associates Science Publishers, Mt. Waverley, 228 pp

    Google Scholar 

  • Bown D (1995) Encyclopaedia of herbs and their uses. Dorling Kindersley, London, 424 pp

    Google Scholar 

  • Burkill IH (1966) A dictionary of the economic products of the Malay Peninsula. Revised reprint, 2 vols. Ministry of Agriculture and Co-operatives, Kuala Lumpur, vol 1 (A–H), pp 1–1240, vol 2 (I–Z), pp 1241–2444

    Google Scholar 

  • Byun MW, Jo C, Jeon TW, Hong CH (2004a) Effects of gamma irradiation on color characteristics and biological activities of extracts of Lonicera japonica (Japanese honeysuckle) with methanol and acetone. LWT- Food Sci Technol 37(1):29–33

    CAS  Google Scholar 

  • Byun MW, Jo C, Lee JW, Jo SK, Kim KS (2004b) Application of radiation technology to develop green tea leaf as a natural resource for the cosmetic industry. Radiat Phys Chem 71:485–487

    Google Scholar 

  • Chang WC, Hsu FL (1992) Inhibition of platelet activation and endothelial cell injury by polyphenolic compounds isolated from Lonicera japonica Thunb. Prostaglandins Leukot Essent Fatty Acids 45(4):307–312

    PubMed  CAS  Google Scholar 

  • Chang HW, Baek SH, Chung KW, Son KH, Kim HP, Kang SS (1994) Inactivation of phospholipase A2 by naturally occurring biflavonoid, ochnaflavone. Biochem Biophys Res Commun 205(1):843–849

    PubMed  CAS  Google Scholar 

  • Chang CW, Lin MT, Lee SS, Liu KC, Hsu FL, Lin JY (1995) Differential inhibition of reverse transcriptase and cellular DNA polymerase-alpha activities by lignans isolated from Chinese herbs, Phyllanthus myrtifolius Moon, and tannins from Lonicera japonica Thunb and Castanopsis hystrix. Antiviral Res 27(4):367–374

    PubMed  CAS  Google Scholar 

  • Chen CX, Wang WW, Ni W, Chen NY, Zhou J (2000) Triterpenoid glycosides from the Lonicera japonica. Acta Metall Sin 22(2):1–3

    Google Scholar 

  • Chen CY, Qi LW, Li HJ, Li P, Yi L, Ma HL, Tang D (2007a) Simultaneous determination of iridoids, phenolic acids, flavonoids, and saponins in Flos Lonicerae and Flos Lonicerae Japonicae by HPLC‐DAD-ELSD coupled with principal component analysis. J Sep Sci 30(18):3181–3192

    PubMed  CAS  Google Scholar 

  • Chen J, Song Y, Li P (2007b) Capillary high-performance liquid chromatography with mass spectrometry for simultaneous determination of major flavonoids, iridoid glucosides and saponins in Flos Lonicerae. J Chromatogr 1157(1–2):217–226

    CAS  Google Scholar 

  • Chen CY, Peng WH, Wu LC, Wu CC, Hsu SL (2010a) Luteolin ameliorates experimental lung fibrosis both in vivo and in vitro: implications for therapy of lung fibrosis. J Agric Food Chem 58(22):11653–11661

    PubMed  CAS  Google Scholar 

  • Chen QZ, Lin RC, Wang GL, Li FM (2010b) Studies on chemical constituents of the extract of Lonicera japonica. Zhong Yao Cai 33(6):920–922 (In Chinese)

    PubMed  CAS  Google Scholar 

  • Chen WC, Liou SS, Tzeng TF, Lee SL, Liu IM (2012) Wound repair and anti-inflammatory potential of Lonicera japonica in excision wound-induced rats. BMC Complement Altern Med 12:226

    PubMed Central  PubMed  Google Scholar 

  • Choi CW, Jung HA, Kang SS, Choi JS (2007) Antioxidant constituents and a new triterpenoid glycoside from Flos Lonicerae. Arch Pharm Res 30(1):1–7

    PubMed  CAS  Google Scholar 

  • Council of Scientific and Industrial Research (CSIR) (1962) The wealth of India. A dictionary of Indian raw materials and industrial products. (Raw materials 6). Publications and Information Directorate, New Delhi

    Google Scholar 

  • Dong J, Tu R, Pan R, Xie X (2008) Lonicera japonica-induced inhibition of interleukin-1 beta thermogenesis and E-type prostaglandin receptor-3 expression in the preoptic area of rabbits. Neural Regen Res 3(2):204–207

    Google Scholar 

  • Duke JA, Ayensu ES (1985) Medicinal plants of China, vol 1 & 2. Reference Publications, Inc, Algonac, 705 pp

    Google Scholar 

  • Dung NT, Bajpai VK, Rahman A, Yoon JI, Kang SC (2011) Phenolic contents, antioxidant and tyrosinase inhibitory activities of Lonicera japonica Thumb. J Food Biochem 35:148–160

    CAS  Google Scholar 

  • El-Kashoury EA, Khaleel AE, Mousa OM, Daoud MH (2007) Anti-cancer volatile constituents from the flowers of Lonicera japonica Thunb. cultivated in Egypt. Egypt J Biomed Sci 23(1):135–145

    CAS  Google Scholar 

  • Facciola S (1990) Cornucopia. A source book of edible plants. Kampong Publications, Vista, 677 pp

    Google Scholar 

  • Fontán N, Alvarez R, de Lera AR (2012) Stereoselective synthesis by olefin metathesis and characterization of η-carotene (7,8,7′,8′-tetrahydro-β, β-carotene). J Nat Prod 75(5):975–979

    PubMed  Google Scholar 

  • Foster S, Duke JA (1998) A field guide to medicinal plants in eastern and central N America. Houghton Mifflin, Boston, 366 pp

    Google Scholar 

  • Gao YM, Wang MZ, Wang JP, Zhan Q, Qin HY, Mu HJ (1995) Studies on the chemical constituents of Japanese honeysuckle (Lonicera japonica). Zhong Cao Yao 26(11):568–569

    CAS  Google Scholar 

  • Goodwin TW (1952) The carotenoids of the berries of Lonicera japonica. Biochem J 51(4):458–463

    PubMed Central  PubMed  CAS  Google Scholar 

  • Han YQ, Ma QC, Jia K, Xue CH (2012) Subcritical R134a extraction of volatile oil from Lonicera japonica. Sci Technol Food Ind 13:197–200

    Google Scholar 

  • Harden GJ (2007) Lonicera japonica Thunb. ex Murray. PlantNET – New South Wales Flora online. The Plant Information Network System of the Royal Botanic Gardens and Domain Trust, Sydney. http://plantnet.rbgsyd.nsw.gov.au

  • Hu S, Cai W, Ye J, Qian Z, Sun Z (1992) Influence of medicinal herbs on phagocytosis by bovine neutrophils. Zentralbl Veterinarmed A 39(8):593–599

    PubMed  CAS  Google Scholar 

  • Huang LY, Lu ZZ, Li JB, Zhou BN (1996) Studies on the chemical constituents of Japanese honeysuckle (Lonicera japonica). Zhong cao yao 27(11):645–647 (In Chinese)

    CAS  Google Scholar 

  • Huh JE, Lee WI, Seo BK, Baek YH, Lee JD, Choi DY, Park DS (2011) Gastroprotective and safety effects of WIN-34B, a novel treatment for osteoarthritis, compared to NSAIDs. J Ethnopharmacol 137(2):1011–1017

    PubMed  Google Scholar 

  • Huh JE, Seo BK, Park YC, Kim JI, Lee JD, Choi DY, Baek YH, Park DS (2012) WIN-34B, a new herbal medicine, inhibits the inflammatory response by inactivating IκB-α phosphorylation and mitogen activated protein kinase pathways in fibroblast-like synoviocytes. J Ethnopharmacol 143(3):779–786

    PubMed  Google Scholar 

  • Ikeda N, Ishihara M, Tsuneya T, Kawakita M, Yoshihara M, Suzuki Y, Komaki R, Inui M (1994) Volatile components of honeysuckle (Lonicera japonica Thunb.) flowers. Flavour Fragr J 9:325–331

    CAS  Google Scholar 

  • Jeong JJ, Ha YM, Jin YC, Lee EJ, Kim JS, Kim HJ, Seo HG, Lee JH, Kang SS, Kim YS, Chang KC (2009) Rutin from Lonicera japonica inhibits myocardial ischemia/reperfusion-induced apoptosis in vivo and protects H9c2 cells against hydrogen peroxide-mediated injury via ERK1/2 and PI3K/Akt signals in vitro. Food Chem Toxicol 47(7):1569–1576

    PubMed  CAS  Google Scholar 

  • Ji L, Pan J, Xu Z (1990) GC-MS analysis of essential oil from flowers of Lonicera japonica Thunb. Zhongguo Zhong Yao Za Zhi 15(11):680–682 (In Chinese)

    PubMed  CAS  Google Scholar 

  • Jung DY, Lee HY, Ha HY, Jung DY, Kang SS, Kim CS (2003) Induction of growth hormone release by the extracts of Lonicera japonica Thunb. Korean J Pharmacogn 34(3):256–262

    CAS  Google Scholar 

  • Kakuda R, Imai M, Yaoita Y, Machida K, Kikuchi M (2000) Secoiridoid glycosides from the flower buds of Lonicera japonica. Phytochemistry 55(8):879–881

    PubMed  CAS  Google Scholar 

  • Kang OH, Choi YA, Park HJ, Lee JY, Kim DK, Choi SC, Kim TH, Nah YH, Yun KJ, Choi SJ, Kim YH, Bae KH, Lee YM (2004) Inhibition of trypsin-induced mast cell activation by water fraction of Lonicera japonica. Arch Pharm 27(11):1141–1146

    CAS  Google Scholar 

  • Kang M, Jung I, Hur J, Kim SH, Lee JH, Kang JY, Jung KC, Kim KS, Yoo MC, Park DS, Lee JD, Cho YB (2010a) The analgesic and anti-inflammatory effect of WIN-34B, a new herbal formula for osteoarthritis composed of Lonicera japonica Thunb and Anemarrhena asphodeloides Bunge in vivo. J Ethnopharmacol 131(2):485–496

    PubMed  Google Scholar 

  • Kang OH, Choi JG, Lee JH, Kwon DY (2010b) Luteolin isolated from the flowers of Lonicera japonica suppresses inflammatory mediator release by blocking NF-kappaB and MAPKs activation pathways in HMC-1 cells. Molecules 15(1):385–398

    PubMed  CAS  Google Scholar 

  • Katano N, Yamamoto H, Iio R, Inoue K (2001) 7-Deoxyloganin 7-hydroxylase in Lonicera japonica cell cultures. Phytochemistry 58(1):53–58

    PubMed  CAS  Google Scholar 

  • Kawai H, Kuroyanagi M, Umehara K (1988a) Iridoid glucosides from Lonicera japonica Thunb. Chem Pharm Bull 36(9):3664–3666

    CAS  Google Scholar 

  • Kawai H, Kuroyanagi M, Umehara K, Ueno A, Satake M (1988b) Studies on the saponins of Lonicera japonica Thunb. Chem Pharm Bull 36(12):4769–4775

    PubMed  CAS  Google Scholar 

  • Kim JA, Kim DK, Kang OH, Choi YA, Park HJ, Choi SC, Kim TH, Yun KJ, Nah YH, Lee YM (2005) Inhibitory effect of luteolin on TNF-alpha-induced IL-8 production in human colon epithelial cells. Int Immunopharmacol 5(1):209–217

    PubMed  CAS  Google Scholar 

  • Kim JS, Yean MH, Lee SY, Lee JH, Kang SS (2009a) Phytochemical studies on Lonicera caulis (1) – Sterols and triterpenoids. Korean J Pharmacogn 40:319–325

    Google Scholar 

  • Kim JS, Yean MH, Lee SY, Lee JH, Kang SS (2009b) Phytochemical studies on Lonicera caulis (3) – Iridoids. Korean J Pharmacogn 40:334–338

    Google Scholar 

  • Kim JS, Yean MH, Seo HK, Lee JH, Kang SS (2009c) Phytochemical studies on Lonicera caulis (2) – Aliphatic and phenolic compounds. Korean J Pharmacogn 40(4):326–333

    Google Scholar 

  • Kumar N, Singh B, Bhandari P, Gupta AP, Uniyal SK, Kaul VK (2005) Biflavonoids from Lonicera japonica. Phytochemistry 66(3):2740–2744

    PubMed  CAS  Google Scholar 

  • Kumar N, Singh B, Gupta AP, Kaul VK (2006) Lonijaposides, novel cerebrosides from Lonicera japonica. Tetrahedron 62:4317–4322

    CAS  Google Scholar 

  • Kunkel G (1984) Plants for human consumption. An annotated checklist of the edible phanerogams and ferns. Koeltz Scientific Books, Koenigstein

    Google Scholar 

  • Kwak WJ, Han CK, Chang HW, Kim HP, Kang SS, Son KH (2003) Loniceroside C, an antiinflammatory saponin from Lonicera japonica. Chem Pharm Bull(Tokyo) 51(3):333–335

    CAS  Google Scholar 

  • Kwon CS, Kim JS, Son KH (2004) Effect of Lonicera japonica flower on body weight gain and glucose tolerance in rodents. Food Sci Biotechnol 13(6):768–771

    Google Scholar 

  • Kwon SH, Hong SI, Kim JA, Jung YH, Kim SY, Kim HC, Lee SY, Jang CG (2011) The neuroprotective effects of Lonicera japonica Thunb. against hydrogen peroxide-induced apoptosis via phosphorylation of MAPKs and PI3K/Akt in SH-SY5Y cells. Food Chem Toxicol 49(4):1011–1019

    PubMed  CAS  Google Scholar 

  • Kwon SH, Hong SI, Jung YH, Kim MJ, Kim SY, Kim HC, Lee SY, Jang CG (2012) Lonicera japonica Thunb. protects 6-hydroxydopamine-induced neurotoxicity by inhibiting activation of MAPKs, PI3K/Akt, and NF-κB in SH-SY5Y cells. Food Chem Toxicol 50(3–4):797–807

    PubMed  CAS  Google Scholar 

  • Lee EJ, Kim JS (2010) Phytochemical studies on Lonicerae Flos (1)-isolation of iridoid glycosides and other constituents. Nat Prod Sci 16(1):32–38

    CAS  Google Scholar 

  • Lee SJ, Son KH, Chang HW, Kang SS, Park PU, Kwak WJ, Han CK, Kim HP (1994) Development of plant anti-inflammatory agents: Comparison of anti-inflammatory and analgesic activities of extracts from Lonicera japonica. Korean J Pharmacogn 25:363–367

    Google Scholar 

  • Lee SJ, Shin EJ, Son KH, Chang HW, Kang SS, Kim HP (1995a) Anti-inflammatory activity of the major constituents of Lonicera japonica. Arch Pharm Res 18(2):133–135

    CAS  Google Scholar 

  • Lee SJ, Son KH, Chang HW, Kang SS, Kim HP (1995b) Anti-inflammatory activity of the major constituents of Lonicera japonica. Arch Pharm Res 18(2):133–135

    CAS  Google Scholar 

  • Lee SJ, Son KH, Chang HW, Kang SS, Kim HP (1998) Antiinflammatory activity of Lonicera japonica. Phytother Res 12(6):445–447

    CAS  Google Scholar 

  • Lee JH, Ko WS, Kim YH, Kang HS, Kim HD, Choi BT (2001) Anti-inflammatory effect of the aqueous extract from Lonicera japonica flower is related to inhibition of NF-kappaB activation through reducing I-kappaBalpha degradation in rat liver. Int J Mol Med 7(1):79–83

    PubMed  CAS  Google Scholar 

  • Lee EJ, Kim JS, Kim HP, Lee JH, Kang SS (2010a) Phenolic constituents from the flower buds of Lonicera japonica and their 5-lipoxygenase inhibitory activities. Food Chem 120(1):134–139

    CAS  Google Scholar 

  • Lee JP, Li YC, Chen HY, Lin RH, Huang SS, Chen HL, Kuan PC, Liao MF, Chen CJ, Kuan YH (2010b) Protective effects of luteolin against lipopolysaccharide-induced acute lung injury involves inhibition of MEK/ERK and PI3K/Akt pathways in neutrophils. Acta Pharmacol Sin 31(7):831–838

    PubMed  CAS  Google Scholar 

  • Lee HJ, Lee DJ, Kim YG, Lee GY, Kim SJ, Jung SK, Jung HJ, Bae HS (2011a) Lipopolysaccharide induced lung inflammation is inhibited by Lonicera japonica. Mol Cell Toxicol 7(1):87–93

    CAS  Google Scholar 

  • Lee HJ, Lee GY, Yoon MS, Hong MC, Shin MK, Bae HS (2011b) Effect of fermented Lonicera japonica on LPS-induced acute lung inflammation. Orient Pharm Exp Med 11(4):287–292

    Google Scholar 

  • Leung HW, Wu CH, Lin CH, Lee HZ (2005) Luteolin induced DNA damage leading to human lung squamous carcinoma CH27 cell apoptosis. Eur J Pharmacol 508(1–3):77–83

    PubMed  CAS  Google Scholar 

  • Leung HW, Kuo CL, Yang WH, Lin CH, Lee HZ (2006) Antioxidant enzymes activity involvement in luteolin-induced human lung squamous carcinoma CH27 cell apoptosis. Eur J Pharmacol 534(1–3):12–18

    PubMed  Google Scholar 

  • Leung HW, Hour MJ, Chang WT, Wu YC, Lai MY, Wang MY, Lee HZ (2008) P38-associated pathway involvement in apoptosis induced by photodynamic therapy with Lonicera japonica in human lung squamous carcinoma CH27 cells. Food Chem Toxicol 46(11):3389–3400

    PubMed  CAS  Google Scholar 

  • Li HJ, Li P (2005) Chemical constituents in flower buds of Lonicera japonica Thunb. Chem Ind For Prod 25:25–32 (In Chinese)

    Google Scholar 

  • Li H, Zhang Z, Li P (2002) Comparative study on volatile oils in flower and stem of Lonicera japonica. Zhong Yao Cai 25(7):476–477 (In Chinese)

    PubMed  CAS  Google Scholar 

  • Li DZ, Tang YB, Kang ZY, Chen RY, Yu DQ (2009a) Synthesis of the anti-virus compound Shuangkangsu’s analogs. J Asian Nat Prod Res 11(7):613–620

    PubMed  CAS  Google Scholar 

  • Li N, You X, Peng J, Wang J (2009b) Comparative study on yield and quality of flower buds of Lonicera japonica within several flowering stages. Zhongguo Zhong Yao Za Zhi 34(11):1346–1350 (In Chinese)

    PubMed  Google Scholar 

  • Li XQ, Sun XH, Cai S, Ying XX, Li FM (2009c) Investigation on the chemical constituents and variation of flower buds of Lonicera species by UPLC-ESI-MS/MS and principle component analysis. Yao Xue Xue Bao 44(8):895–904 (In Chinese)

    PubMed  CAS  Google Scholar 

  • Li ZY, Gao HM, Sun J, Chen LM, Wang ZM, Zhang QW (2012) Secoiridoid sulfonates from the sulfiting-processed buds of Lonicera japonica. Helv Chim Acta 95:1144–1151

    CAS  Google Scholar 

  • Lin LM, Zhang XG, Zhu JJ, Gao HM, Wang ZM, Wang WH (2008) Two new triterpenoid saponins from the flowers and buds of Lonicera japonica. J Asian Nat Prod Res 10(10):925–929

    PubMed  CAS  Google Scholar 

  • Lu HC (2005) Chinese natural cures. Black Dog & Leventhal Publishers, New York, p 512

    Google Scholar 

  • Luo YD, Chen J, Cao J, Wen XD, Li P (2009) Determination of sweroside in rat plasma and bile for oral bioavailability and hepatobiliary excretion. Chem Pharm Bull(Tokyo) 57(1):79–83

    CAS  Google Scholar 

  • Ma SC, But PP, Ooi VE (2005) Determination of the antiviral caffeoyl quinic acids isolated from Lonicera japonica Thunb. Chin J Pharm Anal 25(7):751–755

    Google Scholar 

  • Ma J, Li N, Li X (2009) Caffeoylquinic acid derivatives from leaves of Lonicera japonica. Zhongguo Zhong Yao Za Zhi 34(18):2346–2348 (In Chinese)

    PubMed  CAS  Google Scholar 

  • Machida K, Sasaki H, Iijima T, Kikuchi M (2002) Studies on the constituents of Lonicera species. XVII. New iridoid glycosides of the stems and leaves of Lonicera japonica Thunb. Chem Pharm Bull(Tokyo) 50(8):1041–1044

    CAS  Google Scholar 

  • Mehrotra R, Singh C, Popli SP (1988) Isolation of secoxyloganin from Lonicera japonica and its conversion into secologanin. J Nat Prod 51(2):319–321

    CAS  Google Scholar 

  • Miller JH (2003) Nonnative invasive plants of southern forests: a field guide for identification and control, General technical report SRS-62. U.S. Department of Agriculture, Forest Service, Southern Research Station, Asheville, 93 pp (USDA SRS)

    Google Scholar 

  • Nam KH, Chung HJ, Jeon EJ, Park MK, Yim YH, Liu JR, Park JH (2007) In vitro biosynthesis of strictosidine using Lonicera japonica leaf extracts and recombinant yeast. J Plant Biol 50(3):315–320

    CAS  Google Scholar 

  • National Biological Information Infrastructure (NBII) & IUCN/SSC Invasive Species Specialist Group (ISSG) (2005) Lonicera japonica (vine climber) http://www.issg.org/database/species/ecology.asp?si=158&fr=1&sts=

  • Natural Products Research Institute, Seoul National University (1998) Medicinal plants in the republic of Korea, WHO regional publications, western pacific series no 21. WHO, Manila, 316 pp

    Google Scholar 

  • Niu X, Cui X, Su H, Guo Y, Dong X (2012) Simultaneous determination of seven compounds in Lonicera japonica by high performance liquid chromatography. Se Pu 30(2):211–214 (In Chinese)

    PubMed  CAS  Google Scholar 

  • Oku H, Ogawa Y, Iwaoka E, Ishiguro K (2011) Allergy-preventive effects of chlorogenic acid and iridoid derivatives from flower buds of Lonicera japonica. Biol Pharm Bull 34(8):1330–1333

    PubMed  CAS  Google Scholar 

  • Papageorgiou S, Varvaresou A, Tsirivas E, Demetzos C (2010) New alternatives to cosmetics preservation. J Cosmet Sci 61(2):107–123

    PubMed  CAS  Google Scholar 

  • Park E, Kum S, Wang C, Park SY, Kim BS, Schuller-Levis G (2005) Anti-inflammatory activity of herbal medicines: inhibition of nitric oxide production and tumor necrosis factor-alpha secretion in an activated macrophage-like cell line. Am J Chin Med 33(3):415–424

    PubMed  Google Scholar 

  • Park HS, Park KI, Lee DH, Kang SR, Nagappan A, Kim JA, Kim EH, Lee WS, Shin SC, Hah YS, Kim GS (2012a) Polyphenolic extract isolated from Korean Lonicera japonica Thunb. induce G2/M cell cycle arrest and apoptosis in HepG2 cells: involvements of PI3K/Akt and MAPKs. Food Chem Toxicol 50(7):2407–2416

    PubMed  CAS  Google Scholar 

  • Park KI, Kang SR, Park HS, Lee do H, Nagappan A, Kim JA, Shin SC, Kim EH, Lee WS, Chung HJ, An SJ, Kim GS (2012b) Regulation of proinflammatory mediators via NF-κB and p38 MAPK-dependent mechanisms in RAW 264.7 macrophages by polyphenol components isolated from Korea Lonicera japonica Thunb. Evid Based Complement Altern Med 2012:828521

    Google Scholar 

  • Park JW, Bae H, Lee G, Hong BG, Yoo HH, Lim SJ, Lee K, Kim J, Ryu B, Lee BJ, Bae J, Lee H, Bu Y (2012c) Prophylactic effects of Lonicera japonica extract on dextran sulphate sodium-induced colitis in a mouse model by the inhibition of the Th1/Th17 response. Br J Nutr 9:1–10

    Google Scholar 

  • Peng LY, Mei SX, Jiang B, Zhou H, Sun HD (2000) Constituents from Lonicera japonica. Fitoterapia 71(6):713–715

    PubMed  CAS  Google Scholar 

  • Peng YY, Liu FH, Ye JN (2005) Determination of phenolic acids and flavones in Lonicera japonica Thumb. by capillary electrophoresis with electrochemical detection. Electroanalysis 17(4):356–362

    CAS  Google Scholar 

  • Phan MG, Nguyễn TMH, Phan TS (2005) Các thành phần phenolic của cây kim ngân (Lonicera japonica Thunb., Caprifoliaceae), của Việt Nam. [Phenolic consitutuents of (Lonicera japonica Thunb., Caprifoliaceae), of Vietnam]. TC Hoá Học 43(4):489–493 (In Vietnamese)

    CAS  Google Scholar 

  • Pradhan D, Panda PK, Tripathy G, Nayak JR, Pattanayak A (2009) Anticancer activity of biflavonoids from Lonicera japonica and Benincasa hispida on human cancer cell lines. J Pharm Res 2(5):983–985

    CAS  Google Scholar 

  • Qi LW, Chen CY, Li P (2009) Structural characterization and identification of iridoid glycosides, saponins, phenolic acids and flavonoids in Flos Lonicerae Japonicae by a fast liquid chromatography method with diode-array detection and time-of-flight mass spectrometry. Rapid Commun Mass Spectrom 23(19):3227–3242

    PubMed  CAS  Google Scholar 

  • Qian ZM, Li HJ, Li P, Chen J, Tang D (2007a) Simultaneous quantification of seven bioactive components in Caulis Lonicerae Japonicae by high performance liquid chromatography. Biomed Chromatogr 21(6):649–654

    PubMed  CAS  Google Scholar 

  • Qian ZM, Li HJ, Li P, Ren MT, Tang D (2007b) Simultaneous qualitation and quantification of thirteen bioactive compounds in Flos lonicerae by high-performance liquid chromatography with diode array detector and mass spectrometry. Chem Pharm Bull(Tokyo) 55(7):1073–1076

    CAS  Google Scholar 

  • Qian ZM, Wen XD, Li HJ, Liu Y, Qin SJ, Ping Li P (2008) Analysis of interaction property of bioactive components in Flos Lonicerae Japonicae with protein by microdialysis coupled with HPLC-DAD-MS. Biol Pharm Bull 31(1):126–130

    PubMed  CAS  Google Scholar 

  • Rahman A, Kang SC (2009) In vitro control of food-borne and food spoilage bacteria by essential oil and ethanol extracts of Lonicera japonica Thunb. Food Chem 116:670–675

    CAS  Google Scholar 

  • Rhee KH, Lee KH (2011) Antimicrobial effects of Lonicera japonica against Gram positive and Gram negative anaerobic bacteria. Nat Prod Sci 17(1):23–25

    CAS  Google Scholar 

  • Ryu KH, Rhee HI, Kim JH, Yoo H, Lee BY, Um KA, Kim K, Noh JY, Lim KM, Chung JH (2010) Anti-inflammatory and analgesic activities of SKLJI, a highly purified and injectable herbal extract of Lonicera japonica. Biosci Biotechnol Biochem 74(10):2022–2028

    PubMed  CAS  Google Scholar 

  • Schlotzhauer WS, Pair SD, Horvat RJ (1996) Volatile constituents from the flowers of Japanese honeysuckle (Lonicera japonica). J Agric Food Chem 44(1):206–209

    CAS  Google Scholar 

  • Shang X, Pan H, Li M, Miao X, Ding H (2011) Lonicera japonica Thunb.: ethnopharmacology, phytochemistry and pharmacology of an important traditional Chinese medicine. J Ethnopharmacol 138(1):1–21

    PubMed  CAS  Google Scholar 

  • Shi JY, Guo CJ (2010) Study on effective fraction of anti-influenza virus of flos lonicerae japonicae in vitro. J Shandong Univ Tradit Chin Med 2:044 (In Chinese)

    Google Scholar 

  • Son KH, Park JO, Chung KC, Chang HW, Hyun HP, Kim JS, Kang SS (1992) Flavonoids from the aerial parts of Lonicera japonica. Arch Pharm Res 15(4):365–370

    CAS  Google Scholar 

  • Son KH, Jung KY, Chang HW, Kim HP, Kang SS (1994a) Triterpenoid saponins from the aerial parts of Lonicera japonica. Phytochemistry 35(4):1005–1008

    PubMed  CAS  Google Scholar 

  • Son KH, Kim JS, Kang SS, Kim HP, Chang HW (1994b) Isolation of flavonoids from Lonicera japonica. Korean J Pharmacogn 25(1):24–27

    CAS  Google Scholar 

  • Son MJ, Moon TC, Lee EK, Son KH, Kim HP, Kang SS, Son JK, Lee SH, Chang HW (2006) Naturally occurring biflavonoid, ochnaflavone, inhibits cyclooxygenases-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells. Arch Pharm Res 29(4):282–286

    PubMed  CAS  Google Scholar 

  • Song Y, Li SL, Wu MH, Li HJ, Li P (2006) Qualitative and quantitative analysis of iridoid glycosides in the flower buds of Lonicera species by capillary high performance liquid chromatography coupled with mass spectrometric detector. Anal Chim Acta 564(2):211–218

    CAS  Google Scholar 

  • Song W, Li S, Wang S, Wu Y, Zi J, Gan M, Zhang Y, Liu M, Lin S, Yang Y, Shi J (2008) Pyridinium alkaloid-coupled secoiridoids from the flower buds of Lonicera japonica. J Nat Prod 71(5):922–925

    PubMed  CAS  Google Scholar 

  • Suh SJ, Chung TW, Son MJ, Kim SH, Moon TC, Son KH, Kim HP, Chang HW, Kim CH (2006a) The naturally occurring biflavonoid, ochnaflavone, inhibits LPS-induced iNOS expression, which is mediated by ERK1/2 via NF-kappaB regulation, in RAW264.7 cells. Arch Biochem Biophys 447(2):136–146

    PubMed  CAS  Google Scholar 

  • Suh SJ, Jin UH, Kim SH, Chang HW, Son JK, Lee SH, Son KH, Kim CH (2006b) Ochnaflavone inhibits TNF-alpha-induced human VSMC proliferation via regulation of cell cycle, ERK1/2, and MMP-9. J Cell Biochem 99(5):1298–1307

    PubMed  CAS  Google Scholar 

  • Sun C, Teng Y, Li G, Yoshioka S, Yokota J, Miyamura M, Fang H, Zhang Y (2010) Metabonomics study of the protective effects of Lonicera japonica extract on acute liver injury in dimethylnitrosamine treated rats. J Pharm Biomed Anal 53(1):98–102

    PubMed  CAS  Google Scholar 

  • Tae J, Han SW, Yoo JY, Kim JA, Kang OH, Baek OS, Lim JP, Kim DK, Kim YH, Bae KH, Lee YM (2003) Anti-inflammatory effect of Lonicera japonica in proteinase-activated receptor 2-mediated paw edema. Clin Chim Acta 330(1–2):165–171

    PubMed  CAS  Google Scholar 

  • Tang D, Li HJ, Chen J, Guo CW, Li P (2008) Rapid and simple method for screening of natural antioxidants from Chinese herb Flos Lonicerae Japonicae by DPPH-HPLC-DAD-TOF/MS. J Sep Sci 31(20):3519–3526

    PubMed  CAS  Google Scholar 

  • Tang YB, Huang LJ, Li DZ, Zhang QJ, Chen RY, Yu DQ (2009) The synthesis of analogs of shuangkangsu, a novel natural cycloperoxide glucoside from Lonicera japonica Thunb. J Asian Nat Prod Res 11(2):172–176

    PubMed  CAS  Google Scholar 

  • Teng RW, Wang DZ, Chen CX (2000) Two triterpenoid saponins from Lonicera japonica. Chin Chem Lett 11(4):337–340

    CAS  Google Scholar 

  • Thanabhorn S, Jaijoy K, Thamaree S, Ingkaninan K, Panthong A (2006) Acute and subacute toxicity study of the ethanol extract from Lonicera japonica Thunb. J Ethnopharmacol 107(3):370–373

    PubMed  CAS  Google Scholar 

  • Tomassini L, Cometa MF, Serafini M, Nicoletti M (1995) Isolation of secoiridoid artifacts from Lonicera japonica. J Nat Prod 58(11):1756–1758

    CAS  Google Scholar 

  • Vukovic N, Kacaniova M, Hleba L, Sukdolak S (2012) Chemical composition of the essential oils from the flower, leaf and stem of Lonicera japonica. Nat Prod Commun 7(5):641–644

    PubMed  CAS  Google Scholar 

  • Wang Z, Clifford MN (2008) Comparison of the profiles of chlorogenic acids and their derivatives from three Chinese traditional herbs by LC-MSn. Yao Xue Xue Bao 43(2):185–190

    PubMed  CAS  Google Scholar 

  • Wang N, Yang X (2011) Chemical constitutents from pre-formulation of lonicerae japonicae flos in shuanghuanglian lyophilized powder for injection. Zhongguo Zhong Yao Za Zhi 36(12):1613–1619 (In Chinese)

    PubMed  CAS  Google Scholar 

  • Wang G, Zhu X, Wang J, Jia W, Yuan Y, Nan P, Yuan P (1992) Analysis of chemical constituents of essential oil in Lonicera japonica Thunb. cultivated in the northern plain of Henan Province. Zhongguo Zhong Yao Za Zhi 17(5):268–270 (In Chinese)

    PubMed  CAS  Google Scholar 

  • Wang LM, Li MT, Yan YY, Ao MZ, Wu G, Yu LJ (2009) Influence of flowering stage of Lonicera japonica Thunb. on variation in volatiles and chlorogenic acid. J Sci Food Agric 89:953–957

    CAS  Google Scholar 

  • Webster RM (1993) Honeysuckle contact dermatitis. Cutis 51(6):424

    PubMed  CAS  Google Scholar 

  • Weon JB, Yang HJ, Lee B, Yun BR, Ahn JH, Lee HY, Ma CJ (2011) Neuroprotective activity of the methanolic extract of Lonicera japonica in glutamate-injured primary rat cortical cells. Pharmacogn Mag 7(28):284–288

    PubMed Central  PubMed  Google Scholar 

  • Wu YL, Fang HJ (1980) The constituents of the essential oil from the flowers of Lonicera japonica Thunb. Acta Chem Sin 38:573–579

    CAS  Google Scholar 

  • Xu Y, Oliverson BG, Simmons DL (2007) Trifunctional inhibition of COX-2 by extracts of Lonicera japonica: direct inhibition, transcriptional and post-transcriptional down regulation. J Ethnopharmacol 111(3):667–670

    PubMed  Google Scholar 

  • Yamamoto H, Katano N, Ooi A, Inoue K (2000) Secologanin synthase which catalyzes the oxidative cleavage of loganin into secologanin is a cytochrome P450. Phytochemistry 53(1):7–12

    PubMed  CAS  Google Scholar 

  • Yan HJ (1991) Clinical and experimental study of the effect of kang er xin-I on viral myocarditis. Zhong Xi Yi Jie He Za Zhi 11(8):468–470, 452. (In Chinese)

    PubMed  CAS  Google Scholar 

  • Yang NJ, Liao C, Liu WW, Huo X, Gao YQ, Liu JH (2007) Determination of chemical constituents of the volatile oil from Lonicera japonica Thunb. Chin J Med 7(7):592–597

    CAS  Google Scholar 

  • Yean MH, Kim JS, Lee JH, Kang SS (2010) Lignans from Lonicerae caulis. Nat Prod Sci 16(1):15–19

    CAS  Google Scholar 

  • Yeung HC (1985) Handbook of Chinese herbs and formulas. Institute of Chinese Medicine, Los Angeles

    Google Scholar 

  • Yip ECH, Chan ASL, Pang H, Tam YK, Wong YH (2006) Protocatechuic acid induces cell death in HepG2 hepatocellular carcinoma cells through a c-Jun N-terminal kinase-dependent mechanism. Cell Biol Toxicol 22(4):293–302

    PubMed  CAS  Google Scholar 

  • Yoo HJ, Kang HJ, Song YS, Park EH, Lim CJ (2008) Anti-angiogenic, antinociceptive and anti-inflammatory activities of Lonicera japonica extract. J Pharm Pharmacol 60(6):779–786

    PubMed  CAS  Google Scholar 

  • Yu DQ, Chen RY, Huang LJ, Xie FZ, Ming DS, Zhou K, Li HY, Tong KM (2008) The structure and absolute configuration of Shuangkangsu: a novel natural cyclic peroxide from Lonicera japonica (Thunb.). J Asian Nat Prod Res 10(9–10):851–856

    PubMed  CAS  Google Scholar 

  • Yu Y, Song W, Zhu C, Lin S, Zhao F, Wu X, Yue Z, Liu B, Wang S, Yuan S, Hou Q, Shi J (2011) Homosecoiridoids from the flower buds of Lonicera japonica. J Nat Prod 74(10):2151–2160

    PubMed  CAS  Google Scholar 

  • Zhang C, Yin Z, Ye W, Guan Y, Guo L, Zhang J, Shen W (2009) Chemical constituents from stems of Lonicera japonica. Zhongguo Zhong Yao Za Zhi 34(23):3051–3053 (In Chinese)

    PubMed  Google Scholar 

  • Zhang H, Song J, Shi J (2011) Screen anti-influenza virus serum marker of Lonicera japonica by proteomics technology. Zhongguo Zhong Yao Za Zhi 36(8):1071–1074 (In Chinese)

    PubMed  CAS  Google Scholar 

  • Zheng ZF, Zhang QJ, Chen RY, Yu DQ (2012) Four new N-contained iridoid glycosides from flower buds of Lonicera japonica. J Asian Nat Prod Res 14(8):729–737

    PubMed  CAS  Google Scholar 

  • Zhou R, Tong Q (2003) Comparative study on content of chlorogenic acid in Lonicera japonica and L. macranthoides. Zhong Yao Cai 26(6):399–400 (In Chinese)

    PubMed  Google Scholar 

  • Zhou HY, Zhao NN, Du SS, Yang K, Wang CF, Liu ZL, Qiao YJ (2012) Insecticidal activity of the essential oil of Lonicera japonica flower buds and its main constituent compounds against two grain storage insects. J Med Plant Res 6(5):912–917

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Canberra, Aust Capital Terr, Australia

    T. K. Lim

Authors
  1. T. K. Lim
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Lim, T.K. (2014). Lonicera japonica. In: Edible Medicinal And Non-Medicinal Plants. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7395-0_46

Download citation

Publish with us

Policies and ethics

Search

Navigation