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Transsphenoidal Surgery for Non-Adenomatous Tumors: Effect on Pituitary Function

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Tumors of the Central Nervous System, Volume 12

Part of the book series: Tumors of the Central Nervous System ((TCNS,volume 12))

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Abstract

Pituitary adenomas are the most common intrasellar tumor. However, a wide variety of non-adenomatous lesions also arises in the sellar and parasellar region and can impact pituitary gland function. The lesions most commonly associated with pituitary hormonal disturbance include craniopharyngiomas, Rathke’s cleft cysts, arachnoid cysts and sellar metastases while meningiomas and clival chordomas less commonly affect gland function. Depending on the specific lesion and location, surgical resection can result in improvement or worsening of endocrinopathy. Thorough pre-operative hormonal evaluation, sellar imaging with attention to gland and infundibulum location as well as intra-operative dissection techniques aimed at preserving the hypothalamic-pituitary axis are essential to minimize the risk of new hormonal dysfunction. This chapter discusses the surgical management of these lesions and characterizes the presenting and post-operative pituitary hormonal outcomes related to the specific lesion pathology.

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Authors and Affiliations

  1. John Wayne Cancer Institute at Saint John’s Health Center, 2200 Santa Monica Blvd., Santa Monica, CA, 90404, USA

    Garni Barkhoudarian & Aaron Cutler

  2. Brain Tumor Center, John Wayne Cancer Institute at Saint John’s Health Center, 2200, Santa Monica Blvd., Santa Monica, CA, 90404, USA

    Daniel F. Kelly

Authors
  1. Garni Barkhoudarian
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  2. Aaron Cutler
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  3. Daniel F. Kelly
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Corresponding author

Correspondence to Daniel F. Kelly .

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Editors and Affiliations

  1. Department of Biological Sciences, Kean University, Room 213, Library Building, Union, New Jersey, USA

    M.A. Hayat

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Barkhoudarian, G., Cutler, A., Kelly, D.F. (2014). Transsphenoidal Surgery for Non-Adenomatous Tumors: Effect on Pituitary Function. In: Hayat, M. (eds) Tumors of the Central Nervous System, Volume 12. Tumors of the Central Nervous System, vol 12. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7217-5_21

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  • DOI: https://doi.org/10.1007/978-94-007-7217-5_21

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  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-007-7216-8

  • Online ISBN: 978-94-007-7217-5

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