Molecular Pathology and Diagnostics of Prostate Cancer

  • Rodney E. Shackelford
  • Janese Trimaldi
  • Philippe E. Spiess
  • Wade J. Sexton
  • Maisoun Qassim Abdelbaqi
  • Shang-Tian ChuangEmail author
Part of the Cancer Growth and Progression book series (CAGP, volume 16)


Prostate cancer (PCa) is the most common malignancy among men and is the second leading cause of cancer-related deaths in the United States and Europe. The molecular alterations underlying PCa have recently been shown to be quite complex, involving many different genes, microRNA species, epigenetic and mitochondrial changes, and multiple gene translocations. Because of the highly complex molecular changes underlying this malignancy, PCa molecular diagnostics are exceptionally complex and have only recently led to useful molecular tests. Here, we will review several promising areas in the molecular diagnostics of PCa and try to indicate which ones may have clinical utility in the near future.


Prostate cancer Translocation PSA Molecular diagnostics Mitochondria Prostatic intraepithelial neoplasia Benign prostatic hypertrophy Environmental risk factors Genetic risk factors 



Alpha-methylacyl-CoA racemase


Benign prostatic hypertrophy


Benign prostate-specific antigen


Cancer outlier profile analysis


Circulating tumor cells


Extracellular matrix


Enzyme-linked immunosorbent assay


Epithelial cell adhesion molecule


Erythroblast transformation-specific


Fluorescent in situ hybridization


Free PSA


Golgi Phosphoprotein 2




Glutathione-S-transferase P1


Human glandular kallikrein 2




Matrix metalloproteinase




Phosphate-buffered saline


Prostate cancer


Prostate cancer gene 3


Prostatic intraepithelial neoplasia


Prostate-specific antigen


Reverse transcription-polymerase chain reaction


Single nucleotide polymorphism


Urokinase plasminogen activator


Urokinase plasminogen activator receptor


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Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  • Rodney E. Shackelford
    • 1
  • Janese Trimaldi
    • 2
  • Philippe E. Spiess
    • 3
  • Wade J. Sexton
    • 3
  • Maisoun Qassim Abdelbaqi
    • 4
  • Shang-Tian Chuang
    • 5
    • 6
    Email author
  1. 1.Department of Pathology and Laboratory MedicineTulane University School of MedicineNew OrleansUSA
  2. 2.Department of PathologyH. Lee Moffitt Cancer Center & Research InstituteTampaUSA
  3. 3.Department of Genitourinary OncologyH. Lee Moffitt Cancer Center & Research InstituteTampaUSA
  4. 4.Department of PathologyLSU Health Sciences Center ShreveportShreveportUSA
  5. 5.PathologyEast Los Angeles Doctors HospitalLos AngelesUSA
  6. 6.Los AngelesUSA

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