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Molecular Diagnostics of Lymphoid Neoplasms

  • Deniz Peker
  • Jianguo Tao
  • Ling ZhangEmail author
Chapter
  • 2.5k Downloads
Part of the Cancer Growth and Progression book series (CAGP, volume 16)

Abstract

According to 2008 World Health Organization (WHO) Classification of Tumors of Hematopoietic and Lymphoid Tissue, lymphoid neoplasms are divided into two, mature and immature (precursors), forms including mature B and T/NK cell leukemia/lymphomas and B and T-lymphoblastic leukemia/lymphomas (B-ALL/LBL, T-ALL/LBL). Nowadays a variety of molecular methods are introduced for the modern classification of lymphoid neoplasm system. Although morphological characteristics remain the cornerstone of the evaluation of lymphoid neoplasm, ancillary studies e.g. immunophenotyping and PCR study for T- and B-cell gene rearrangements are routinely implicated in daily service. Different from myeloid neoplasms, the application of molecular/genetic diagnosis and subclassification of lymphoid neoplasm are mainly limited in B-ALL. There are few known protooncogenes or cytogenetic abnormalities in the certain T/NK or B lymphoid malignancies. The chapter focuses on common molecular diagnostic approaches and molecules that implicated in therapeutic strategies, predicting prognosis and monitoring minimal residual disease.

Keywords

Lymphoid malignancy Cytogenetics Molecular Gene rearrangement Diagnostic and prognostic implications Novel molecular techniques 

Abbreviations

ABC

Activated B cell-like type

ALK

Anaplastic large cell kinase

ALL

Acute lymphoblastic leukemias

ALTCL

Anaplastic large T cell lymphoma

ATM

Ataxia telangiectasia mutated gene

B-ALL

B-lymphoblastic leukemia/lymphoma

BL

Burkitt lymphoma

B-PLL

B-cell prolymphocytic leukemia

CDK6

Cyclin dependent kinase 6 gene

CLL/SLL

Chronic lymphocytic leukemia/small lymphocytic lymphoma

CNS

Central nervous system

CRA

Common region of amplification

DAPK1

Death-associated protein kinase 1

DLBCL

Diffuse large B-cell lymphoma

FFPE

Formalin-fixed and paraffin-embedded

FISH

Fluorescence in situ hybridization

FNA

Fine needle aspirate

GCB

Germinal center B-cell like

iAMP21

Intrachromosomal amplification of chromosome 21

LPL

Lymphoplasmacytic lymphoma

M-bcr

Major breakpoint cluster region

m-bcr

“minor” breakpoint cluster region

MF

Mycosis fungoides

MLPA

Multiplex ligation-dependent probe amplification

MRD

Minimal residual disease

NK

Natural killer

Non-GCB

Non-germinal center B-cell like

NPM

Nucleophosmin gene

PCR

Polymerase Chain Reaction

PTCL, NOS

Peripheral T cell lymphoma, not otherwise specified

RT-PCR

Reverse Polymerase Chain Reaction

SHM

Somatic hypermutation

SMZL

Splenic marginal zone lymphoma

SNP

Single Nucleotide Polymorphism Array

T-ALL

T-lymphoblastic leukemia/lymphoma

TCR

T cell gene rearrangement

TKI

Tyrosine kinase inhibitor

UDP

Uniparental disomy

WHO

World Health Organization

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Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  1. 1.Department of Pathology and Cell BiologyUniversity of South Florida College of MedicineTampaUSA
  2. 2.Department of Hematopathology and Laboratory MedicineMoffitt Cancer Center & Research InstituteTampaUSA

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