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Molecular Pathology and Diagnostics of Gynecologic Malignancies

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Molecular Pathology and Diagnostics of Cancer

Part of the book series: Cancer Growth and Progression ((CAGP,volume 16))

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Abstract

Gynecologic malignancies account for roughly 13 % of solid tissue tumors in women. Many of these malignancies, such as many ovarian tumors, first present at an advanced stage, making them difficult to treat. Until recently the analysis of these malignancies was largely limited to hematoxylin-eosin-stained slide examination, supplemented with immunohistochemical stains. Recently, molecular diagnostic techniques have been applied to these tumors with some success, especially with BRCA1/2 mutations and Lynch syndrome analyses. Here, we describe the present molecular diagnostic tests applied to gynecologic malignancies and discuss possible future developments in this field.

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Abbreviations

CDK:

Cyclin-dependent protein kinase

dsDNA:

Double-stranded DNA

EST:

Endometrial stromal tumor

FDA:

US Food and Drug Administration

HNPCC:

Hereditary nonpolyposis colorectal cancer

HPV:

Human papilloma virus

HRM:

High-resolution melting analysis

MMMT:

Malignant mixed mullerian tumor

Nampt:

Nicotinamide phosphoribosyltransferase

PCR:

Polymerase chain reaction

PJS:

Peutz-Jeghers syndrome

UCCC:

Uterine clear cell carcinoma

UEA:

Uterine endometrial adenocarcinoma

USC:

Uterine serous carcinoma

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We would like to thank Miss Jennifer Burton for her help in manuscript preparation and proof reading.

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  1. Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, 1430 Tulane Avenue, SL-79, New Orleans, LA, 70112, USA

    Rodney E. Shackelford

  2. Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL, 33612, USA

    Masoumeh Ghayouri, Domenico Coppola & Ardeshir Hakam M.D.

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  1. Rodney E. Shackelford
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  2. Masoumeh Ghayouri
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  3. Domenico Coppola
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  4. Ardeshir Hakam M.D.
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  1. Anatomic Pathology, University of South Florida, Moffitt Cancer Center, Tampa, Florida, USA

    Domenico Coppola

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Shackelford, R.E., Ghayouri, M., Coppola, D., Hakam, A. (2014). Molecular Pathology and Diagnostics of Gynecologic Malignancies. In: Coppola, D. (eds) Molecular Pathology and Diagnostics of Cancer. Cancer Growth and Progression, vol 16. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7192-5_12

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