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Molecular Pathology and Diagnostics of Cancer pp 329–340Cite as

Molecular Diagnosis of Bladder and Kidney Cancer

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Part of the book series: Cancer Growth and Progression ((CAGP,volume 16))

Abstract

This chapter will review the molecular diagnosis of bladder and kidney cancer. In current clinical practice, early detection and diagnosis of urothelial carcinoma is based on urinary cytology. UroVysion™ bladder cancer fluorescence in situ hybridization (FISH) has become a useful ancillary test in the detection of urothelial carcinoma for initial diagnosis and recurrence; this test is applicable to routine cytologic urine specimens. Multiple studies have shown that UroVysion™ FISH in voided urine and washing specimens can help in patient management due to its superior sensitivity over cytology in certain situations. Within the renal cortex, molecular studies have not achieved routine use; the most widely available tests are used to identify Xp11.2 translocations/TFE fusions for the subclassification of renal cell carcinoma.

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Abbreviations

BCG:

Bacillus Calmette-Guerin

BTA:

Bladder Tumor Antigen

CEP:

Chromosome Enumeration Probes

FDP:

Fibrinogen Degradation Products

FDP:

Fibrinogen Degradation

FGFR3:

Fibroblast Growth Factor Receptor 3

FISH:

Fluorescent in Situ Hybridization

hCFHrp:

Human Complement Factor H Related Protein

LSI:

Locus Specific Identifier

TPS:

Tissue Polypeptide Specific

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Authors and Affiliations

  1. Department of Anatomic Pathology, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine, 12902 Magnolia Drive, Tampa, FL, 33612, USA

    Marino E. Leon M.D.

  2. Department of Hematopathology and Laboratory Medicine and Anatomic Pathology, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine, 12902 Magnolia Drive, Tampa, FL, 33612, USA

    Dahui Qin M.D., Ph.D.

  3. Department of Pathology, The Ohio State University, Wexner Medical Center, Columbus, OH, USA

    Debra L. Zynger M.D.

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  1. Marino E. Leon M.D.
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  2. Dahui Qin M.D., Ph.D.
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  3. Debra L. Zynger M.D.
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Correspondence to Marino E. Leon M.D. .

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Editors and Affiliations

  1. Anatomic Pathology, University of South Florida, Moffitt Cancer Center, Tampa, Florida, USA

    Domenico Coppola

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Leon, M.E., Qin, D., Zynger, D.L. (2014). Molecular Diagnosis of Bladder and Kidney Cancer. In: Coppola, D. (eds) Molecular Pathology and Diagnostics of Cancer. Cancer Growth and Progression, vol 16. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7192-5_10

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