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Molecular Pathology and Diagnostics of Gliomas

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Molecular Pathology and Diagnostics of Cancer

Part of the book series: Cancer Growth and Progression ((CAGP,volume 16))

Abstract

Gliomas are the most common primary malignancy in the central nervous system. With recent advancements in molecular pathology, pathologists now have additional tools for histologic analysis of these brain tumors. Genomic and proteomic studies may aid in the diagnosis of gliomas, as well as have utility in prognostication and response to treatment options. Presented are the most current molecular studies utilized in neuropathology of gliomas, as well as a glimpse to future potential biomarkers.

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Abbreviations

2HG:

(R)-2-hydroxyglutarate

COBRA:

Combined bisulfite restriction analysis

EGFR:

Epidermal growth factor receptor

FISH:

Fluorescent in situ hybridization

IDH:

Isocitrate dehydrogenase

LOH:

Loss of heterozygosity

MALDI-TOF:

Matrix assisted laser desorption ionization—time of flight

MAPK:

Mitogen-activated protein kinase

MGMT:

O6-methylguanine-DNA methyltransferase

miRNA:

microRNA

MMP:

Matrix metalloproteinase

MS:

Mass spectroscopy

MS-MLPA:

Methylation-specific multiplex ligation-dependent probe amplification

PTEN:

Phosphatase and tensin homolog

RT-PCR:

Reverse transcription-polymerase chain reaction

SELDI-TOF:

Surface enhanced laser desorption ionization—time of flight

WHO:

World Health Organization

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Authors and Affiliations

  1. University of South Florida, Tampa, FL, USA

    Jesse Kresak

  2. Department of Anatomic Pathology, Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, 33612, USA

    Yuan (Frank) Shan M.D.

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  1. Jesse Kresak
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Correspondence to Yuan (Frank) Shan M.D. .

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Editors and Affiliations

  1. Anatomic Pathology, University of South Florida, Moffitt Cancer Center, Tampa, Florida, USA

    Domenico Coppola

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Kresak, J., Shan, Y.(. (2014). Molecular Pathology and Diagnostics of Gliomas. In: Coppola, D. (eds) Molecular Pathology and Diagnostics of Cancer. Cancer Growth and Progression, vol 16. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7192-5_1

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