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Prostate Cancer: Shifting from Morphology to Biology pp 57–77Cite as

Apoptosis and Autophagy

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Abstract

Defects in both apoptotic and non-apoptotic cell-death pathways are strictly associated with tumorigenesis. In particular, resistance to apoptosis is considered to be an hallmark of cancer cells. Defects in apoptosis underlie not only tumorigenesis, but also resistance to cancer treatments.

A better definition of non-apoptotic and apoptotic cell-death pathways interactions is needed. Since the first attempts of cell deaths classification, the caspase-dependent, tolerogenic, programmed and physiological cell death instances have been contrasted to their caspase-independent, immunogenic, accidental and pathological counterparts. However, further investigation of non-apoptotic pathways might provide new therapeutic strategies aimed at inducing the non-apoptotic death of cancer cells.

In the present chapter, apoptotic and non-apoptotic cell death pathways are discussed for what concern neoplastic transformation of prostate gland.

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  1. Department of Advanced Biomedical Sciences, Pathology Section, Faculty of Medicine and Surgery, University of Naples “Federico II”, via S. Pansini, n.5, Naples, Italy

    Francesco Merolla

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  1. Biomedical Advanced Sciences Pathology Section, University Federico II of Naples, Naples, Italy

    Stefania Staibano

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Merolla, F. (2013). Apoptosis and Autophagy. In: Staibano, S. (eds) Prostate Cancer: Shifting from Morphology to Biology. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7149-9_3

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