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Constitutive Effects of Hydrolytic Degradation in Electro-Spun Polyester-Urethane Scaffolds for Soft Tissue Regeneration

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Tissue Engineering

Part of the book series: Computational Methods in Applied Sciences ((COMPUTMETHODS,volume 31))

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Abstract

In tissue regenerative implants, porosity allowing the ingrowth of cells and tissue is a key factor for the long-term success. While vital for healing and tissue regeneration, the use of highly porous structures may adversely affect the mechanical properties of the scaffold, in particular when viscoelastic polymeric materials are used. In the case of biodegradable scaffold materials, the effect of the degradation process on mechanical and structural properties of the scaffold is yet another aspect to be considered. Both tissue ingrowth and biodegradation are concurrent transient processes which change the mechanical and structural properties of the implanted device over time. Ingrowth of cells and tissue typically results in an increase in structural stiffness whereas scaffold degradation leads to loss of mechanical properties and potentially to structural disintegration. The aim of the research presented in this chapter was the investigation of the change of mechanical properties of a biodegradable, electro-spun polyester-urethane scaffold for soft tissue regeneration during hydrolytic degradation and the development of a constitutive model that is suitable for capturing these changes.

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Acknowledgements

The authors thank ab medica S.p.A for donating the DegraPol® material for this study. ETH Zurich and University of Zurich are owners and ab medica S.p.A is exclusive licensee of all IP Rights of DegraPol®.

Funding Sources

This study was supported financially by the National Research Foundation (NRF) of South Africa. Any opinion, findings and conclusions or recommendations expressed in this publication are those of the authors and therefore the NRF does not accept any liability in regard thereto. HK received a Matching Dissertation Grant from the International Society of Biomechanics.

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Authors and Affiliations

  1. Cardiovascular Research Unit, Chris Barnard Division of Cardiothoracic Surgery, University of Cape Town, Cape Town, South Africa

    Hugo Krynauw, Lucie Bruchmüller, Deon Bezuidenhout, Peter Zilla & Thomas Franz

  2. Centre for Research in Computational and Applied Mechanics, University of Cape Town, Rondebosch, Cape Town, South Africa

    Thomas Franz

  3. Research Office, University of Cape Town, Mowbray, Observatory, Cape Town, South Africa

    Thomas Franz

Authors
  1. Hugo Krynauw
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  2. Lucie Bruchmüller
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  3. Deon Bezuidenhout
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  4. Peter Zilla
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  5. Thomas Franz
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Corresponding author

Correspondence to Hugo Krynauw .

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Editors and Affiliations

  1. Instituto Superior Tecnico Mechanical Engineering Dept., Technical University of Lisbon, Grande Lisboa, Portugal

    Paulo Rui Fernandes

  2. CDRSP – IP Leiria Portugal, Marinha Grande, Portugal

    Paulo Jorge Bartolo

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Krynauw, H., Bruchmüller, L., Bezuidenhout, D., Zilla, P., Franz, T. (2014). Constitutive Effects of Hydrolytic Degradation in Electro-Spun Polyester-Urethane Scaffolds for Soft Tissue Regeneration. In: Fernandes, P., Bartolo, P. (eds) Tissue Engineering. Computational Methods in Applied Sciences, vol 31. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7073-7_3

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  • DOI: https://doi.org/10.1007/978-94-007-7073-7_3

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-007-7072-0

  • Online ISBN: 978-94-007-7073-7

  • eBook Packages: EngineeringEngineering (R0)

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