Abstract
To improve diagnosis of brain injury (BI), it is critical to identify its symptoms early. We describe here a portable and cost effective device that may be able to detect BI in field. This report includes our recent publications devoted to devices based on near infra-red spectroscopy (NIRS) that can objectively detect, quantify, and record exposures that may cause BI as well capable of measuring changes in brain activity, physiology, or function that may be associated with BI. Another important task is to determine which devices are appropriate for use in the combat zone and civil environment, device size and ease of use. The results of the review revealed that empirical data characterizing BI in humans early after injury are lacking, making it difficult to critically evaluate and compare different devices and the measures they provide. Detailed consideration of many papers indicate that there is a critical need to determine the sensitivity and specificity of diagnostic devices in detecting BI, compare their ability to discriminate BI, and provide a better understanding of brain pathology and physiology immediately following injury.
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References
Bright R (1831) Reports of medical cases selected with a view of illustrating the symptoms and care of diseases by a reference to morbid anatomy, vol 2, Diseases of the brain and nervous system. Longman, London, pp 431–435
Barozzino T, Sgro M (2002) Trans-illumination of the neonatal skull: seeing the light. J De l’Assoc Med Can 167(11):12717–12727
Cope M, Delpy DT (1988) System for long-term measurement of cerebral blood and tissue oxygenation on newborn infants by near infra-red transillumination. Med Biol Eng Comput 26(3):289–294
Jobsis FF (1977) Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. Science 198(4323):1264
Matcher SJ, Elwell CE, Cooper CE, Cope M, Delpy DT (1995) Performance comparison of several published tissue near-infrared spectroscopy algorithms. Anal Biochem 227:54–68. doi:10.1006/abio.1995.1252
Brazy JE, Lewis DV, Mitnick MH, vander Vliet FF (1985) Noninvasive monitoring of cerebral oxygenation in preterm infants: preliminary observations. Pediatrics 75(2):217
Young AE, Germon TJ, Barnett NJ, Manara AR, Nelson RJ (2000) Behaviour of near-infrared light in the adult human head: implications for clinical near-infrared spectroscopy. Br J Anaesth 84(1):38
Al-Rawi PG (2005) Near infrared spectroscopy in brain injury: today’s perspective. Acta Neurochir Suppl 95:453–457
Calderon-Arnulphi M, Alaraj A, Slavin KV (2009) Near infrared technology in neuroscience: past, present and future. Neurol Res 31(6):605–614
Muhlemann TL (2010) A novel wireless near- infrared spectrophotometer applied to measure cortical haemodynamics in humans and sheep. ETH (Swiss Federal Institute of Technology) dissertation no 19051
Al-Rawi PG, Smielewski P, Kirkpatrick PJ (2001) Evaluation of a near-infrared spectrometer (NIRO 300) for the detection of intracranial oxygenation changes in the adult head. Stroke 32(11):2492
Colier W, Haaren N, Oeseburg B (1995) A comparative study of two near infrared spectrophotometers for the assessment of cerebral haemodynamics. Acta Anaesthesiol Scand 39(s107):101–105
Grubhofer G, Tonninger W, Keznickl P, Skyllouriotis P, Ehrlich M, Hiesmayr M, Lassnigg A (1999) A comparison of the monitors INVOS 3100 and NIRO 500 in detecting changes in cerebral oxygenation. Acta Anaesthesiol Scand 43(4):470
McKeating EG, Monjardino JR, Signorini DF, Souter MJ, Andrews PJD (1997) A comparison of the Invos 3100 and the Critikon 2020 near-infrared spectrophotometers as monitors of cerebral oxygenation. Anaesthesia 52(2):136–140
Thavasothy M, Broadhead M, Elwell C, Peters M, Smith M (2002) A comparison of cerebral oxygenation as measured by the NIRO 300 and the INVOS 5100 near-infrared spectrophotometers. Anaesthesia 57(10):999–1006
Matcher SJ, Elwell CE, Cooper CE, Cope M, Delpy DT (1995) Performance comparison of several published tissue near-infrared spectroscopy algorithms. Anal Biochem 227(1):54–68
Al-Rawi PG, Kirkpatrick PJ (2006) Tissue oxygen index: thresholds for cerebral ischemia using near-infrared spectroscopy. J Cereb Circ 37(11):2720–2725
Gopinath SP, Robertson CS, Grossman RG, Chance B (1993) Near-infrared spectroscopic localization of intracranial hematomas. J Neurosurg 79(1):43–47
Ghalenoui H, Saidi H, Azar M, Yahyavi ST, Borghei Razavi H, Khalatbari M (2008) Near-infrared laser spectroscopy as a screening tool for detecting hematoma in patients with head trauma. Prehosp Disaster Med 23(6):558–561, The Official Journal of the National Association of EMS Physicians and the World Association for Emergency and Disaster Medicine in Association with the Acute Care Foundation
Cassis LA, Lodder RA (1993) Near-IR imaging of atheromas in living arterial tissue. Anal Chem 65:1247–1256
Caplan JD, Waxman S, Nesto RW, Muller JE (2006) Near-infrared spectroscopy for the detection of vulnerable coronary artery plaques. J Am Coll Cardiol 47(8s1):C92–C96
Dempsey RJ, Davis DG, Buice RG et al (1996) Biological and medical applications of near-infrared spectroscopy. Appl Spectrosc 50:18A–34A
Jaross W, Neumeister V, Lattke P et al (1999) Determination of cholesterol in atherosclerotic plaques using near infrared diffuse reflection spectroscopy. Atherosclerosis 147:327–337
Neumeister V, Scheibe M, Lattke P, Jaross W (2002) Determination of the cholesterol-collagen ratio of arterial atherosclerotic plaques using near infrared spectroscopy as a possible measure of plaque stability. Atherosclerosis 165:251–257
Wang J, Geng YJ, Guo B et al (2002) Near-infrared spectroscopic characterization of human advanced atherosclerotic plaques. J Am Coll Cardiol 39:1305–1313
Pasley BN, Freeman RD (2008) Neurovascular coupling. Scholarpedia 3(3):5340, Brain Corporation
Wolf M, Greisen G (2009) Advances in near-infrared spectroscopy to study the brain of the preterm and term neonate. Clin Perinatol 36:807–834
Villringer A (1997) Understanding functional neuroimaging methods based on neurovascular coupling. Adv Exp Med Biol 413:177–193
Vernieri F, Rosato N, Pauri F, Tibuzzi F, Passarelli F, Rossini PM (1999) Near infrared spectroscopy and transcranial Doppler inmonohemispheric stroke. Eur Neurol 41:159–162
Delpy DT, Cope M, van der Zee P, Arridge S, Wray S, Wyatt J (1988) Estimation of optical path length through tissue from direct time of flight measurement. Phys Med Biol 33:1433–1442
Mehagnoul-Schipper DJ, Vloet LCM, Colier WNJM, Hoefnagels WHL, Jansen RWMM (2000) Cerebral oxygenation declines in healthy elderly subjects in response to assuming the uprightposition. Stroke 31:1615–1620
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Paiziev, A. (2013). Portable Point-of-Care Optical Device to Detect Brain Injury. In: Vaseashta, A., Khudaverdyan, S. (eds) Advanced Sensors for Safety and Security. NATO Science for Peace and Security Series B: Physics and Biophysics. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7003-4_16
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