Skip to main content

Portable Point-of-Care Optical Device to Detect Brain Injury

  • Conference paper
  • First Online:
Book cover Advanced Sensors for Safety and Security

Abstract

To improve diagnosis of brain injury (BI), it is critical to identify its symptoms early. We describe here a portable and cost effective device that may be able to detect BI in field. This report includes our recent publications devoted to devices based on near infra-red spectroscopy (NIRS) that can objectively detect, quantify, and record exposures that may cause BI as well capable of measuring changes in brain activity, physiology, or function that may be associated with BI. Another important task is to determine which devices are appropriate for use in the combat zone and civil environment, device size and ease of use. The results of the review revealed that empirical data characterizing BI in humans early after injury are lacking, making it difficult to critically evaluate and compare different devices and the measures they provide. Detailed consideration of many papers indicate that there is a critical need to determine the sensitivity and specificity of diagnostic devices in detecting BI, compare their ability to discriminate BI, and provide a better understanding of brain pathology and physiology immediately following injury.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Bright R (1831) Reports of medical cases selected with a view of illustrating the symptoms and care of diseases by a reference to morbid anatomy, vol 2, Diseases of the brain and nervous system. Longman, London, pp 431–435

    Google Scholar 

  2. Barozzino T, Sgro M (2002) Trans-illumination of the neonatal skull: seeing the light. J De l’Assoc Med Can 167(11):12717–12727

    Google Scholar 

  3. Cope M, Delpy DT (1988) System for long-term measurement of cerebral blood and tissue oxygenation on newborn infants by near infra-red transillumination. Med Biol Eng Comput 26(3):289–294

    Article  CAS  Google Scholar 

  4. Jobsis FF (1977) Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. Science 198(4323):1264

    Article  CAS  Google Scholar 

  5. Matcher SJ, Elwell CE, Cooper CE, Cope M, Delpy DT (1995) Performance comparison of several published tissue near-infrared spectroscopy algorithms. Anal Biochem 227:54–68. doi:10.1006/abio.1995.1252

    Article  CAS  Google Scholar 

  6. Brazy JE, Lewis DV, Mitnick MH, vander Vliet FF (1985) Noninvasive monitoring of cerebral oxygenation in preterm infants: preliminary observations. Pediatrics 75(2):217

    CAS  Google Scholar 

  7. Young AE, Germon TJ, Barnett NJ, Manara AR, Nelson RJ (2000) Behaviour of near-infrared light in the adult human head: implications for clinical near-infrared spectroscopy. Br J Anaesth 84(1):38

    Article  CAS  Google Scholar 

  8. Al-Rawi PG (2005) Near infrared spectroscopy in brain injury: today’s perspective. Acta Neurochir Suppl 95:453–457

    Article  CAS  Google Scholar 

  9. Calderon-Arnulphi M, Alaraj A, Slavin KV (2009) Near infrared technology in neuroscience: past, present and future. Neurol Res 31(6):605–614

    Article  Google Scholar 

  10. Muhlemann TL (2010) A novel wireless near- infrared spectrophotometer applied to measure cortical haemodynamics in humans and sheep. ETH (Swiss Federal Institute of Technology) dissertation no 19051

    Google Scholar 

  11. Al-Rawi PG, Smielewski P, Kirkpatrick PJ (2001) Evaluation of a near-infrared spectrometer (NIRO 300) for the detection of intracranial oxygenation changes in the adult head. Stroke 32(11):2492

    Article  CAS  Google Scholar 

  12. Colier W, Haaren N, Oeseburg B (1995) A comparative study of two near infrared spectrophotometers for the assessment of cerebral haemodynamics. Acta Anaesthesiol Scand 39(s107):101–105

    Article  Google Scholar 

  13. Grubhofer G, Tonninger W, Keznickl P, Skyllouriotis P, Ehrlich M, Hiesmayr M, Lassnigg A (1999) A comparison of the monitors INVOS 3100 and NIRO 500 in detecting changes in cerebral oxygenation. Acta Anaesthesiol Scand 43(4):470

    Article  CAS  Google Scholar 

  14. McKeating EG, Monjardino JR, Signorini DF, Souter MJ, Andrews PJD (1997) A comparison of the Invos 3100 and the Critikon 2020 near-infrared spectrophotometers as monitors of cerebral oxygenation. Anaesthesia 52(2):136–140

    Article  CAS  Google Scholar 

  15. Thavasothy M, Broadhead M, Elwell C, Peters M, Smith M (2002) A comparison of cerebral oxygenation as measured by the NIRO 300 and the INVOS 5100 near-infrared spectrophotometers. Anaesthesia 57(10):999–1006

    Article  CAS  Google Scholar 

  16. Matcher SJ, Elwell CE, Cooper CE, Cope M, Delpy DT (1995) Performance comparison of several published tissue near-infrared spectroscopy algorithms. Anal Biochem 227(1):54–68

    Article  CAS  Google Scholar 

  17. Al-Rawi PG, Kirkpatrick PJ (2006) Tissue oxygen index: thresholds for cerebral ischemia using near-infrared spectroscopy. J Cereb Circ 37(11):2720–2725

    Article  Google Scholar 

  18. Gopinath SP, Robertson CS, Grossman RG, Chance B (1993) Near-infrared spectroscopic localization of intracranial hematomas. J Neurosurg 79(1):43–47

    Article  CAS  Google Scholar 

  19. Ghalenoui H, Saidi H, Azar M, Yahyavi ST, Borghei Razavi H, Khalatbari M (2008) Near-infrared laser spectroscopy as a screening tool for detecting hematoma in patients with head trauma. Prehosp Disaster Med 23(6):558–561, The Official Journal of the National Association of EMS Physicians and the World Association for Emergency and Disaster Medicine in Association with the Acute Care Foundation

    Google Scholar 

  20. Cassis LA, Lodder RA (1993) Near-IR imaging of atheromas in living arterial tissue. Anal Chem 65:1247–1256

    Article  CAS  Google Scholar 

  21. Caplan JD, Waxman S, Nesto RW, Muller JE (2006) Near-infrared spectroscopy for the detection of vulnerable coronary artery plaques. J Am Coll Cardiol 47(8s1):C92–C96

    Article  Google Scholar 

  22. Dempsey RJ, Davis DG, Buice RG et al (1996) Biological and medical applications of near-infrared spectroscopy. Appl Spectrosc 50:18A–34A

    Article  CAS  Google Scholar 

  23. Jaross W, Neumeister V, Lattke P et al (1999) Determination of cholesterol in atherosclerotic plaques using near infrared diffuse reflection spectroscopy. Atherosclerosis 147:327–337

    Article  CAS  Google Scholar 

  24. Neumeister V, Scheibe M, Lattke P, Jaross W (2002) Determination of the cholesterol-collagen ratio of arterial atherosclerotic plaques using near infrared spectroscopy as a possible measure of plaque stability. Atherosclerosis 165:251–257

    Article  CAS  Google Scholar 

  25. Wang J, Geng YJ, Guo B et al (2002) Near-infrared spectroscopic characterization of human advanced atherosclerotic plaques. J Am Coll Cardiol 39:1305–1313

    Article  Google Scholar 

  26. Pasley BN, Freeman RD (2008) Neurovascular coupling. Scholarpedia 3(3):5340, Brain Corporation

    Article  Google Scholar 

  27. Wolf M, Greisen G (2009) Advances in near-infrared spectroscopy to study the brain of the preterm and term neonate. Clin Perinatol 36:807–834

    Article  Google Scholar 

  28. Villringer A (1997) Understanding functional neuroimaging methods based on neurovascular coupling. Adv Exp Med Biol 413:177–193

    Article  CAS  Google Scholar 

  29. Vernieri F, Rosato N, Pauri F, Tibuzzi F, Passarelli F, Rossini PM (1999) Near infrared spectroscopy and transcranial Doppler inmonohemispheric stroke. Eur Neurol 41:159–162

    Article  CAS  Google Scholar 

  30. Delpy DT, Cope M, van der Zee P, Arridge S, Wray S, Wyatt J (1988) Estimation of optical path length through tissue from direct time of flight measurement. Phys Med Biol 33:1433–1442

    Article  CAS  Google Scholar 

  31. Mehagnoul-Schipper DJ, Vloet LCM, Colier WNJM, Hoefnagels WHL, Jansen RWMM (2000) Cerebral oxygenation declines in healthy elderly subjects in response to assuming the uprightposition. Stroke 31:1615–1620

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Adkham Paiziev .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer Science+Business Media Dordrecht

About this paper

Cite this paper

Paiziev, A. (2013). Portable Point-of-Care Optical Device to Detect Brain Injury. In: Vaseashta, A., Khudaverdyan, S. (eds) Advanced Sensors for Safety and Security. NATO Science for Peace and Security Series B: Physics and Biophysics. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7003-4_16

Download citation

Publish with us

Policies and ethics