Abstract
The histocompatibility system is responsible for the rejection of allografts. The system exists to counter the explosive speed of viral replication (Table 3.1). It does this by directing the defensive immune attack by cytotoxic T cells on to histocompatibility antigens that have been altered by extrusion of a viral peptide on the infected cell’s surface [1]. This enables destruction of the virus factories that the infected cells become, before the cytotoxic T cells are swamped by the myriad numbers of new virions, a thousand coming from each infected cell every 10 h in influenza infection [2]. The immunity system mistakes alloantigens for virus-infected host cells that need swift destruction.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Zinkernagel RM, Doherty PC. Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semi-allogenic system. Nature. 1974; 248: 701–702.
Fenner F, White DO. Medical virology. London: Academic Press; 1975.
Kaplan HS. Hodgkin’s disease: unfolding concepts concerning its nature, management and prognosis. Cancer. 1980;45:2439–74.
Slavin S, Reitz B, Bieber C, Kaplan HS, Strober S. Transplantation tolerance in adult rats using total lymphoid irradiation; permanent survival of skin, heart and marrow allografts. J Exp Med. 1978;147:700–7.
Sykes M. Mixed chimerism and transplant tolerance. Immunity. 2001;14:417–24.
Adams DD. Why the histocompatibility system exists and how transplant surgeons can xenograft without rejection. Q J Med. 2011;104:767–9.
Acknowledgments
We are indebted to Pro-Vice-Chancellor, Peter Crampton for encouragement, information, advice and administrative support.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Copyright information
© 2013 The Author(s)
About this chapter
Cite this chapter
Adams, D.D., Adams, C.D. (2013). Transplantation. In: Autoimmune Disease. SpringerBriefs in Public Health. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6937-3_7
Download citation
DOI: https://doi.org/10.1007/978-94-007-6937-3_7
Published:
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-007-6936-6
Online ISBN: 978-94-007-6937-3
eBook Packages: MedicineMedicine (R0)